Atelectasis After Pulmonary Lobectomy: The Effect Of Air During One-Lung Ventilation (OLV) On Postoperative Atelectasis

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

70 participants

Study Classification

INTERVENTIONAL

Study Start Date

2010-07-31

Study Completion Date

2011-06-30

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Patients scheduled for lung lobe resection using video assisted thoracic surgery will be randomly assigned to be ventilated with either only oxygen or a mixture of air and oxygen.

The primary purpose of this study is to determine if the incidence of postoperative collapse (in the non-surgical lung) is decreased when using a mixture of air and oxygen compared to using only oxygen (which is our control measurement) during one-lung ventilation.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Pressure-Controlled vs Volume-Controlled Ventilation During One Lung Ventilation

NCT00975468

Thoracic Surgery

SUSPENDED NA

Comparison of Two Strategies of One-lung Ventilation in Patients Undergoing Carcinological Lung Resection Surgery.

NCT05525312

Lung Diseases

RECRUITING NA

Does PEP Compensate the Reduction of Tidal Volume During One Lung Ventilation?

NCT00534690

Lung Neoplasms Pulmonary Disease

COMPLETED NA

The Effect of Two Airway Interventions, During One Lung Ventilation, on Blood Oxygen Content

NCT01495936

Thoracic, Diseases

UNKNOWN NA

Individualized Perioperative Open-Lung Ventilatory Strategy During One-Lung Ventilation

NCT03182062

Thoraric Surgery Surgery Time Expected More Than Two Hours

UNKNOWN NA

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

One of the concerns with all thoracic procedures employing One Lung Ventilation (OLV) is intra-operative hypoxia due to the large shunt that develops when only one lung is being ventilated. Ventilation with a higher fraction of inspired oxygen (FIO2) is one of the commonly chosen strategies for the treatment of hypoxemia during (OLV) for thoracic surgery. Using an FIO2 of 1.0 at all times during (OLV), however, may increase the risk of absorption atelectasis intra and postoperatively which itself leads to persistent hypoxia and potentially pneumonia.

The aim of this study is therefore to determine the impact of adding air to the inspired fraction of oxygen during (OLV) primarily on the incidence of postoperative atelectasis of the nonsurgical lung after lung resection using video assisted thoracic surgery and secondarily on intraoperative and postoperative oxygenation.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Pulmonary Atelectasis

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

DOUBLE

Participants Outcome Assessors

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Air/Oxygen Mixture

Patients in this group will be ventilated with a mixture of air and oxygen during one lung ventilation.

Group Type EXPERIMENTAL

One Lung Ventilation

Intervention Type OTHER

Patients in this group will be ventilated with a mixture of air and oxygen during one lung ventilation.

Oxygen

Patients in this group will be ventilated with only oxygen during one lung ventilation.

Group Type ACTIVE_COMPARATOR

One Lung Ventilation

Intervention Type OTHER

Patients in this group will be ventilated with only oxygen during one lung ventilation.

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

One Lung Ventilation

Patients in this group will be ventilated with a mixture of air and oxygen during one lung ventilation.

Intervention Type OTHER

One Lung Ventilation

Patients in this group will be ventilated with only oxygen during one lung ventilation.

Intervention Type OTHER

Other Intervention Names

Discover alternative or legacy names that may be used to describe the listed interventions across different sources.

OLV OLV

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Age 18 years or older
* Competent to give consent to enroll in study
* Booked for open thoracotomy procedure for lobectomy
* American Society of Anesthesiologists comorbidity score 1-4

Exclusion Criteria

* Unable or unwilling to give consent
* Pregnant women
* Inability to insert an arterial line
* Severe COPD (FEV1 \< .7% predicted, or FEV1/FVC \< 0.70)
* Presence of other significant pulmonary impairment (PaO2 on room air 50 mmHg, PaCO2 \> 50 mmHg or known pulmonary HTN mean PAP \> 25 mmHg)
* Presence of significant cardiovascular disease (+MIBI that is non-revascularized, CCS ≥ 3 angina, NYHA ≥ 3 CHF, EF (by angiography or echocardiogram \< 40%)
* Chronic renal failure (serum Cr \> 200)
* Altered liver function

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No