Apolipoprotein E Gene and Functional MRI

NCT ID: NCT01287819

Last Updated: 2019-09-19

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 200 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2012-05-31
• Study Completion Date: 2013-04-18

Brief Summary

1. Apolipoprotein E gene (ApoE) is the most important genetic factor for Alzheimer disease (AD) and an important genetic factor for outcome of brain injury situations.

2. Function magnetic resonance imaging (fMRI) is a powerful tool for study of both brain regional functions and brain network.

3. Study about genetic contribution on fMRI is an emerging concept, which will help on understanding about how the genetics affecting the brain function.

Detailed Description

There are about 4-10% people aged and over 65 years suffering from dementia in Taiwan. Dementia caused by diverse diseases, including Alzheimer's disease (AD), fronto-temporal dementia (FTD), dementia with Lewy body (DLB), Parkinson's disease dementia (PDD) and vascular dementia (VaD), is a neurodegenerative disease characterized by memory impairment, cognitive dysfunctions, behavioral disturbances and various kinds of psychiatric manifestations. AD is the most common cause of dementia in the world. Although the real pathophysiology of AD is still obscure, the compelling evidence has shown genetic factor should play an important role in the occurrence of AD. There are three genes, in terms of amyloid precursor protein (APP), presenilin-1 (PS1) and presenilin-2 (PS2), linked in the familial AD. Mutations on these genes would result in familial AD, which account for only less than 5% of AD. The only one well-documented genetic risk factor for sporadic AD is apolipoprotein E, ε4 allele (ApoE4). ApoE gene contains three genetic polymorphisms, ε2, 3, 4 and ApoE4 has been found associated with many brain injury situations, such as poor outcome for traumatic brain injury (TBI), Parkinson disease dementia (PDD). These findings might support ApoE to be important for brain functions but the real mechanisms remain further clarification. Functional magnetic resonance imaging (fMRI) is a powerful tool for study of both brain regional functions and brain network. To our knowledge, only few reports in top journals indicated genetic background is an important contributor for fMRI presentations. This could be a new filed of neuroscience. In this study, we will explore whether ApoE genetic polymorphisms affect the presentation of fMRI and realize some functions of ApoE in the brain. In addition, our data could enhance the new concept about the association between genetics and brain function.

Conditions

Dementia

Study Design

• Observational Model Type: CASE_CONTROL
• Study Time Perspective: CROSS_SECTIONAL

Study Groups

APOE4 (+) and APE4 (-)

APOE4 (+) 10 people APOE4 (-) 20 people from 200 participants

No interventions assigned to this group

Eligibility Criteria

Inclusion Criteria

• people aged 45-65 years without cognitive impairment

Exclusion Criteria

• unable to take APOE genotyping or undergo functional MRI

• Minimum Eligible Age: 45 Years
• Maximum Eligible Age: 65 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Chang Gung Memorial Hospital

OTHER

Sponsor Role: collaborator

Taipei Medical University Shuang Ho Hospital

OTHER

Sponsor Role: lead

Responsible Party

Chaur-jong Hu

Chief of Neurology department

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Chaur-Jong Hu, M.D.

Role: PRINCIPAL_INVESTIGATOR

Taipei Medical University Shuang Ho Hospital

Locations

Chaur-Jong Hu

New Taipei City, , Taiwan

Countries

Taiwan

References

Chen CJ, Chen CC, Wu D, Chi NF, Chen PC, Liao YP, Chiu HW, Hu CJ. Effects of the apolipoprotein E epsilon4 allele on functional MRI during n-back working memory tasks in healthy middle-aged adults. AJNR Am J Neuroradiol. 2013 Jun-Jul;34(6):1197-202. doi: 10.3174/ajnr.A3369. Epub 2012 Dec 28.

Reference Type: DERIVED

PMID: 23275593 (View on PubMed)

Other Identifiers

CRC-12-10-04

Identifier Type: -

Identifier Source: org_study_id