Nerve Growth Factor in Chronic Pancreatitis

NCT ID: NCT01255917

Last Updated: 2016-03-07

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

38 participants

Study Classification

OBSERVATIONAL

Study Start Date

2008-02-29

Study Completion Date

2011-08-31

Brief Summary

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This study is to understand the role of nerve growth factor(NGF) and other cytokines in the pancreatic fluid of patients with chronic pancreatitis.

Hypothesis:

1. Pain does not correlate with changes in the PD morphology suggesting that pain in CP is not only a mechanical problem
2. Pain in CP correlates better with the levels of NGF in the pancreatic juice. NGF is variably expressed in different morphological stages of CP and regulates the sensitivity of the peptidergic nociceptors and is upregulated in pancreatic inflammation.

Detailed Description

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Conditions

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Chronic Pancreatitis

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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Chronic pancreatitis

No interventions assigned to this group

Eligibility Criteria

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Exclusion Criteria

* Failure to obtain consent.
* Any comorbid condition with expected survival \< 1 year.
* Patients with pacemaker, implanted metallic prosthesis or other contraindications to do MRCP.
* Patients \< 18 years of age at time of consent
Minimum Eligible Age

18 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Stanford University

OTHER

Sponsor Role collaborator

Virginia Commonwealth University

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Bimaljit S Sandhu, M.D

Role: PRINCIPAL_INVESTIGATOR

Associate Professor, VCU Medical Center

Locations

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Virginia Commonwealth University Medical Center

Richmond, Virginia, United States

Site Status

Countries

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United States

Other Identifiers

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HM11033

Identifier Type: -

Identifier Source: org_study_id

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