Determinants of Depression and Its Impact on Quality of Life in Patients With Chronic Pancreatitis
NCT ID: NCT04867304
Last Updated: 2021-04-30
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
625 participants
OBSERVATIONAL
2018-02-01
2020-01-31
Brief Summary
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In the current study, we proposed to evaluate the the relationship between pain, quality of life and depression status in two large independent cohorts of patients with CP. We also proposed to evaluate the brain metabolites in the right and left anterior cingulate cortex, basal ganglia, hippocampus and prefrontal cortex using magnetic resonance spectroscopy. We further proposed to evaluate the pasta metabolites and look for associations with the mental state. Finally, we proposed to evaluate how CP related education of the patients could impact on their mental status and response to interventions on pain.
Detailed Description
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Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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Healthy controls
Individuals without any known illnesses and normal labs./USG w/a. This group was used to compare baseline depression, magnetic resonance spectroscopy and plasma metabolites.
No interventions assigned to this group
Chronic pancreatitis without depression
This group contains patients with CP who does not have depression based on the Beck Depression inventory.
Patient education about chronic pancreatitis.
Patients in the second cohort were educated about their disease phenotype in a structured and personalised manner that included their disease course, symptoms, imaging, treatment option and possible long-term outcomes and prognosis. This was followed by answering all the queries of the patient and their caregivers.
The patients were advised to visit the Pancreas clinic after 3-months for re-evaluation of the clinical, psychological and metabolic parameters.
Chronic pancreatitis with depression
This group contains patients with CP who has depression based on the Beck Depression inventory.
Patient education about chronic pancreatitis.
Patients in the second cohort were educated about their disease phenotype in a structured and personalised manner that included their disease course, symptoms, imaging, treatment option and possible long-term outcomes and prognosis. This was followed by answering all the queries of the patient and their caregivers.
The patients were advised to visit the Pancreas clinic after 3-months for re-evaluation of the clinical, psychological and metabolic parameters.
Interventions
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Patient education about chronic pancreatitis.
Patients in the second cohort were educated about their disease phenotype in a structured and personalised manner that included their disease course, symptoms, imaging, treatment option and possible long-term outcomes and prognosis. This was followed by answering all the queries of the patient and their caregivers.
The patients were advised to visit the Pancreas clinic after 3-months for re-evaluation of the clinical, psychological and metabolic parameters.
Eligibility Criteria
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Inclusion Criteria
* Both genders
* Documented CP for at least 3 years
* Capable and willing to provide informed consent
Exclusion Criteria
* Pancreatic malignancy
* On anti-depressant and antipsychotic medications
* Concomitant psychiatric illness (other than depression)
* Pancreatic malignancy
* Major co-morbidities
* Pregnancy and lactation
18 Years
60 Years
ALL
Yes
Sponsors
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Asian Institute of Gastroenterology, India
OTHER
Responsible Party
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Rupjyoti Talukdar
Director, Pancreas Clinic; Head, Pancreas Research Group
Locations
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Asian Institute of Gastroenterology
Hyderabad, Andhra Pradesh, India
Countries
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Other Identifiers
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AIG-DEPCP-01
Identifier Type: -
Identifier Source: org_study_id