Creon After Pancreatic Surgery

NCT ID: NCT00535756

Last Updated: 2011-08-18

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

58 participants

Study Classification

INTERVENTIONAL

Study Start Date

2008-04-30

Study Completion Date

2011-06-30

Brief Summary

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This study will provide efficacy data for Creon 25000 MMS in PS patients as well as long-term safety data. During the long-term treatment with Creon 25000 nutritional parameters will be assessed and correlated with CFA

Detailed Description

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Conditions

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Pancreatic Insufficiency

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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1

Group Type EXPERIMENTAL

Creon

Intervention Type DRUG

3 capsules Creon with 25000 lipase units per main meal (3 main meals) plus 2 capsules per snack (2-3 snacks)

2

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type DRUG

Placebo

Interventions

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Creon

3 capsules Creon with 25000 lipase units per main meal (3 main meals) plus 2 capsules per snack (2-3 snacks)

Intervention Type DRUG

Placebo

Placebo

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

Pancreatic exocrine insufficiency has to be proven (in medical history) by the following criteria:

* Direct or indirect pancreatic function test (except stool fat excretion) and
* Steatorrhoea: stool fat \> 15 g/day (using van de Kamer method)
* Proven chronic pancreatitis
* Females of child-bearing potential must agree to continue using a medically acceptable method of birth control

Exclusion Criteria

* Subjects in an unstable situation (catabolic) after pancreatic surgery
* Ileus or acute abdomen
* Current excessive intake of alcohol or drug abuse
* Hypersensitivity vs porcine proteins / pancreatin
* Subjects taking digestive enzyme preparations have to stop them before start of the run-in period
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Quintiles, Inc.

INDUSTRY

Sponsor Role collaborator

Data Map GmbH

UNKNOWN

Sponsor Role collaborator

Abbott Products

INDUSTRY

Sponsor Role lead

Responsible Party

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Abbott Products

Principal Investigators

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Guenter Krause, MD

Role: STUDY_DIRECTOR

Abbott Products

Locations

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Site Reference ID/Investigator# 45022

Rousse, , Bulgaria

Site Status

Site Reference ID/Investigator# 45020

Sofia, , Bulgaria

Site Status

Site Reference ID/Investigator# 45026

Greifswald, , Germany

Site Status

Site Reference ID/Investigator# 45025

Hamburg, , Germany

Site Status

Site Reference ID/Investigator# 45027

Heidelberg, , Germany

Site Status

Site Reference ID/Investigator# 45024

Munich, , Germany

Site Status

Site Reference ID/Investigator# 45126

Békéscsaba, , Hungary

Site Status

Site Reference ID/Investigator# 45121

Budaörs, , Hungary

Site Status

Site Reference ID/Investigator# 45127

Dunaújváros, , Hungary

Site Status

Site Reference ID/Investigator# 45115

Gyula, , Hungary

Site Status

Site Reference ID/Investigator# 45116

Sopron, , Hungary

Site Status

Site Reference ID/Investigator# 45114

Szeged, , Hungary

Site Status

Site Reference ID/Investigator# 45130

Bologna, , Italy

Site Status

Site Reference ID/Investigator# 45129

Padua, , Italy

Site Status

Site Reference ID/Investigator# 45128

Verona, , Italy

Site Status

Countries

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Bulgaria Germany Hungary Italy

Other Identifiers

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2005-004854-29

Identifier Type: EUDRACT_NUMBER

Identifier Source: secondary_id

S245.4.008

Identifier Type: -

Identifier Source: org_study_id

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