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Does Administration of Etomidate and Propofol of the Anesthetic Induction of Elderly Hypertensive Patient Provide Superior Blood Pressure Stability in Response to Direct Laryngoscopy When Compared to Propofol or Etomidate Alone?

NCT ID: NCT01248234

Last Updated: 2012-07-16

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

WITHDRAWN

Clinical Phase

PHASE3

Study Classification

INTERVENTIONAL

Study Start Date

2012-07-31

Study Completion Date

2012-07-31

Brief Summary

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This study will attempt to show that a combination of drugs, Etomidate and Propofol, provide a more stable blood pressure when used to put elderly hypertensive patients to sleep than either drug used alone.

Detailed Description

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Same as above.

Conditions

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Hypertension

Keywords

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elderly hypertensive anesthesia

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Blinding Strategy

NONE

Study Groups

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Propofol

Propofol alone will be used to put an elderly hypertensive patient to sleep for surgery.

Group Type ACTIVE_COMPARATOR

propofol

Intervention Type DRUG

Propofol 1mg/kg will be given once to put the patient to sleep for surgery.

Etomidate

Etomidate alone will be used to put an elderly hypertensive patient to sleep.

Group Type ACTIVE_COMPARATOR

Etomidate

Intervention Type DRUG

Etomidate 0.3mg/kg will be given once to put the patient to sleep for surgery.

Propofol and Etomidate

A combination of Etomidate and Propofol will be used to put an elderly hypertensive patient to sleep for surgery.

Group Type ACTIVE_COMPARATOR

Propofol and Etomidate

Intervention Type DRUG

Etomidate 0.2mg/kg plus Propofol 0.5mg/kg will be given once to put the patient to sleep for surgery.

Interventions

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propofol

Propofol 1mg/kg will be given once to put the patient to sleep for surgery.

Intervention Type DRUG

Etomidate

Etomidate 0.3mg/kg will be given once to put the patient to sleep for surgery.

Intervention Type DRUG

Propofol and Etomidate

Etomidate 0.2mg/kg plus Propofol 0.5mg/kg will be given once to put the patient to sleep for surgery.

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Patients at least 65 years old, with a history of hypertension.

Exclusion Criteria

* Patients less than 65 years old or without a history of hypertension.
Minimum Eligible Age

65 Years

Maximum Eligible Age

90 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University of Mississippi Medical Center

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Cynthia A Vaughn, MD

Role: STUDY_CHAIR

University of Mississippi Medical Center

Locations

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University of Mississippi Medical Center

Jackson, Mississippi, United States

Site Status

Countries

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United States

Other Identifiers

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2010-0097

Identifier Type: -

Identifier Source: org_study_id