Polarization Sensitive Retinal Tomography for Glaucoma Diagnosis
NCT ID: NCT01222065
Last Updated: 2012-03-27
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
85 participants
OBSERVATIONAL
2007-08-31
2011-03-31
Brief Summary
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1. To determine reproducibility of peripapillary birefringence maps and identify features that measure the health of the RNFL.
2. To determine the normal variation in the birefringence maps with age.
3. To develop and test a classifier for glaucoma based on the birefringence maps using a case-control clinical trial.
This study is a case-control study intended to optimize feature selection for a future multi-center blinded study. The proposed clinical study does not measure conversion from normal to glaucoma.
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Detailed Description
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Conditions
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Study Design
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CASE_CONTROL
CROSS_SECTIONAL
Study Groups
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Glaucoma/Normal
Two groups will be studies: patients with glaucomatous visual field loss and age and gender matched normal patients without visual field loss
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
40 Years
80 Years
ALL
Yes
Sponsors
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National Eye Institute (NEI)
NIH
Courtney Frazier Swaney
OTHER
Responsible Party
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Courtney Frazier Swaney
Office of Sponsored Projects
Principal Investigators
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Henry G Rylander, MD
Role: PRINCIPAL_INVESTIGATOR
University of Texas at Austin
Locations
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Eye Institute of Austin
Austin, Texas, United States
Countries
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References
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Park J, Kemp NJ, Rylander HG 3rd, Milner TE. Complex polarization ratio to determine polarization properties of anisotropic tissue using polarization-sensitive optical coherence tomography. Opt Express. 2009 Aug 3;17(16):13402-17. doi: 10.1364/oe.17.013402.
Pocock GM, Aranibar RG, Kemp NJ, Specht CS, Markey MK, Rylander HG 3rd. The relationship between retinal ganglion cell axon constituents and retinal nerve fiber layer birefringence in the primate. Invest Ophthalmol Vis Sci. 2009 Nov;50(11):5238-46. doi: 10.1167/iovs.08-3263. Epub 2009 Jun 3.
Liu S, Paranjape AS, Elmaanaoui B, Dewelle J, Rylander HG 3rd, Markey MK, Milner TE. Quality assessment for spectral domain optical coherence tomography (OCT) images. Proc SPIE Int Soc Opt Eng. 2009;7171:71710X. doi: 10.1117/12.809404.
Related Links
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BME website with links to faculty
Other Identifiers
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2007-04-0101
Identifier Type: -
Identifier Source: org_study_id
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