Study to Evaluate the Contraceptive Efficacy/Safety of a Low Dose EE/LNG Transdermal Contraceptive Delivery System

NCT ID: NCT01181479

Last Updated: 2018-07-03

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

View full results

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

1504 participants

Study Classification

INTERVENTIONAL

Study Start Date

2010-08-31

Study Completion Date

2012-03-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The purpose of the study is to evaluate the efficacy and safety of a low dose transdermal contraceptive delivery system containing ethinyl estradiol and levonorgestrel.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Comparative evaluation of AG200-15 versus OC with regard to safety, contraceptive efficacy, cycle control (bleeding pattern), subject compliance and serum concentrations of EE and LNG. To evaluate TCDS wearability (including adhesion).

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Contraception

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

NONE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

AG200-15 (cycles 1-13)

AG200-15 containing ethinyl estradiol and levonorgestrel. Type of intervention is drug.

Group Type EXPERIMENTAL

AG200-15 (cycles 1-13)

Intervention Type DRUG

AG200-15 containing ethinyl estradiol and levonorgestrel

Lessina crossover to AG200-15

Lessina containing ethinyl estradiol and levonorgestrel for 6 cycles followed by AG200-15 for 6 cycles. Type of intervention is drug.

Group Type ACTIVE_COMPARATOR

Lessina crossover to AG200-15

Intervention Type DRUG

Low dose oral contraceptive containing 20 mcg ethinyl estradiol and 100 mcg Levonorgestrel in 21 day regimen for 6 cycles followed by AG200-15 for 6 cycles.

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

AG200-15 (cycles 1-13)

AG200-15 containing ethinyl estradiol and levonorgestrel

Intervention Type DRUG

Lessina crossover to AG200-15

Low dose oral contraceptive containing 20 mcg ethinyl estradiol and 100 mcg Levonorgestrel in 21 day regimen for 6 cycles followed by AG200-15 for 6 cycles.

Intervention Type DRUG

Other Intervention Names

Discover alternative or legacy names that may be used to describe the listed interventions across different sources.

transdermal patch hormonal oral contraception and transdermal patch

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

Healthy females

* 17(in states where the legal age of consent to receive contraceptives is 17)-40 years
* Regular, consistent menstrual cycles between 25 and 35 days
* Sexually active women requesting birth control
* In good general health, confirmed by medical history, physical (including gynecologic) examination and screening laboratory values

Exclusion Criteria

* Known or suspected pregnancy;
* Lactating women
* Significant skin reaction to transdermal preparations or sensitivity to surgical / medical tape
* Any disease that may worsen under hormonal treatment (cardiovascular, liver, metabolic)
* Use of other contraceptive methods than study medication
Minimum Eligible Age

17 Years

Maximum Eligible Age

40 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Agile Therapeutics

INDUSTRY

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Responsibility Role SPONSOR

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

Elizabeth Garner, MD, MPH

Role: STUDY_DIRECTOR

Agile Therapeutics

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

Agile Investigational Site

Huntsville, Alabama, United States

Site Status

Agile Investigational Site

Mobile, Alabama, United States

Site Status

Agile Investigational Site

Chandler, Arizona, United States

Site Status

Agile Investigational Site

Green Valley, Arizona, United States

Site Status

Agile Investigational Site

Tucson, Arizona, United States

Site Status

Agile Investigational Site

Little Rock, Arkansas, United States

Site Status

Agile Investigational Site

La Mesa, California, United States

Site Status

Agile Investigational Site

Los Angeles, California, United States

Site Status

Agile Investigational

Sacramento, California, United States

Site Status

Agile Investigational Site

San Diego, California, United States

Site Status

Agile Investigational Site

Santa Ana, California, United States

Site Status

Agile Investigational Site

Vista, California, United States

Site Status

Agile Investigational Site

West Hills, California, United States

Site Status

Agile Investigational Site

Boulder, Colorado, United States

Site Status

Agile Investigational Site

Colorado Springs, Colorado, United States

Site Status

Agile Investigational Site

Denver, Colorado, United States

Site Status

Agile Investigational Site

Fort Collins, Colorado, United States

Site Status

Agile Investigational Site

Wheat Ridge, Colorado, United States

Site Status

Agile Investigational Site

Milford, Connecticut, United States

Site Status

Agile Investigational Site

New London, Connecticut, United States

Site Status

Agile Investigational Site

Waterbury, Connecticut, United States

Site Status

Agile Investigational Site

Boynton Beach, Florida, United States

Site Status

Agile Investigational Site

Clearwater, Florida, United States

Site Status

Agile Investigational Site

Daytona Beach, Florida, United States

Site Status

Agile Investigational Site

DeLand, Florida, United States

Site Status

Agile Investigational Site

Fort Myers, Florida, United States

Site Status

Agile Investigational Site

Jacksonville, Florida, United States

Site Status

Agile Investigational Site

Pinellas Park, Florida, United States

Site Status

Agile Investigational Site

South Miami, Florida, United States

Site Status

Agile Investigational Site

St. Petersburg, Florida, United States

Site Status

Agile Investigational Site

West Palm Beach, Florida, United States

Site Status

Agile Investigational Site

Atlanta, Georgia, United States

Site Status

Agile Investigational Site

Decatur, Georgia, United States

Site Status

Agile Investigational Site

Sandy Springs, Georgia, United States

Site Status

Agile Investigational Site

Champaign, Illinois, United States

Site Status

Agile Investigational Site

Chicago, Illinois, United States

Site Status

Agile Investigational Site

Indianapolis, Indiana, United States

Site Status

Agile Investigational Site

Newburgh, Indiana, United States

Site Status

Agile Investigational Site

Overland Park, Kansas, United States

Site Status

Agile Investigational Site

Wichita, Kansas, United States

Site Status

Agile Investigational Site

Lexington, Kentucky, United States

Site Status

Agile Investigational Site

Louisville, Kentucky, United States

Site Status

Agile Investigational Site

Marrero, Louisiana, United States

Site Status

Agile Investigational Site

Lincoln, Nebraska, United States

Site Status

Agile Investigational Site

Las Vegas, Nevada, United States

Site Status

Agile Investigational Site

Edison, New Jersey, United States

Site Status

Agile Investigational Site

Lawrenceville, New Jersey, United States

Site Status

Agile Investigational Site

Rochester, New York, United States

Site Status

Agile Investigational Site

Cary, North Carolina, United States

Site Status

Agile Investigational Site

Charlotte, North Carolina, United States

Site Status

Agile Investigational Site

Kernersville, North Carolina, United States

Site Status

Agile Investigational Site

Raleigh, North Carolina, United States

Site Status

Agile Investigational Site

Salisbury, North Carolina, United States

Site Status

Agile Investigational Site

Wilmington, North Carolina, United States

Site Status

Agile Investigational Site

Winston-Salem, North Carolina, United States

Site Status

Agile Investigational Site

Akron, Ohio, United States

Site Status

Agile Investigational Site

Cincinnati, Ohio, United States

Site Status

Agile Investigational Site

Cleveland, Ohio, United States

Site Status

Agile Investigational Site

Columbus, Ohio, United States

Site Status

Agile Investigational Site

Englewood, Ohio, United States

Site Status

Agile Investigational Site

Mayfield Heights, Ohio, United States

Site Status

Agile Investigational Site

Oklahoma City, Oklahoma, United States

Site Status

Agile Investigational Site

Tulsa, Oklahoma, United States

Site Status

Agile Investigational Site

Medford, Oregon, United States

Site Status

Agile Investigational Site

Jackson, Tennessee, United States

Site Status

Agile Investigational Site

Knoxville, Tennessee, United States

Site Status

Agile Investigational Site

Memphis, Tennessee, United States

Site Status

Agile Investigational Site

Austin, Texas, United States

Site Status

Agile Investigational Site

Bedford, Texas, United States

Site Status

Agile Investigational Site

Corpus Christi, Texas, United States

Site Status

Agile Investigational Site

Dallas, Texas, United States

Site Status

Agile Investigational Site

Houston, Texas, United States

Site Status

Agile Investigational Site

San Antonio, Texas, United States

Site Status

Agile Investigational Site

Sugar Land, Texas, United States

Site Status

Agile Investigational Site

Webster, Texas, United States

Site Status

Agile Investigational Site

Salt Lake City, Utah, United States

Site Status

Agile Investigational Site

Newport News, Virginia, United States

Site Status

Agile Investigational Site

Norfolk, Virginia, United States

Site Status

Agile Investigational Site

Richmond, Virginia, United States

Site Status

Agile Investigational Site

Seattle, Washington, United States

Site Status

Countries

Review the countries where the study has at least one active or historical site.

United States

References

Explore related publications, articles, or registry entries linked to this study.

Kaunitz AM, Portman D, Westhoff CL, Mishell DR Jr, Archer DF, Foegh M. New contraceptive patch wearability assessed by investigators and participants in a randomized phase 3 study. Contraception. 2015 Mar;91(3):211-6. doi: 10.1016/j.contraception.2014.11.013. Epub 2014 Nov 25.

Reference Type DERIVED
PMID: 25586864 (View on PubMed)

Kaunitz AM, Portman D, Westhoff CL, Archer DF, Mishell DR Jr, Foegh M. Self-reported and verified compliance in a phase 3 clinical trial of a novel low-dose contraceptive patch and pill. Contraception. 2015 Mar;91(3):204-10. doi: 10.1016/j.contraception.2014.11.011. Epub 2014 Nov 25.

Reference Type DERIVED
PMID: 25582984 (View on PubMed)

Kaunitz AM, Portman D, Westhoff CL, Archer DF, Mishell DR Jr, Rubin A, Foegh M. Low-dose levonorgestrel and ethinyl estradiol patch and pill: a randomized controlled trial. Obstet Gynecol. 2014 Feb;123(2 Pt 1):295-303. doi: 10.1097/AOG.0000000000000095.

Reference Type DERIVED
PMID: 24402597 (View on PubMed)

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

57731

Identifier Type: OTHER

Identifier Source: secondary_id

ATI-CL12

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.