Transdermal Contraceptive Delivery System (TCDS), Also Known as AG200-15 Patch Arm

NCT ID: NCT01236768

Last Updated: 2017-09-15

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

407 participants

Study Classification

INTERVENTIONAL

Study Start Date

2010-10-31

Study Completion Date

2011-06-30

Brief Summary

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The purpose of the study is to evaluate the efficacy and safety of a low dose transdermal contraceptive delivery system containing ethinyl estradiol and levonorgestrel.

Detailed Description

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Comparative evaluation of AG200-15 versus OC with regard to safety, contraceptive efficacy, hormone related adverse events, lipid profile, cycle control (bleeding pattern), subject compliance and serum concentrations of EE and LNG. To evaluate TCDS wearability (including adhesion).

Conditions

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Contraception

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

NONE

Study Groups

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AG200-15

Thin transdermal contraceptive delivery system (TCDS) that gives systemic exposure of levonorgestrel (LNG) and ethinyl estradiol (EE)

Group Type EXPERIMENTAL

AG200-15

Intervention Type DRUG

Contraception; AG200-15 is applied and replaced every 7 days for 3 weeks, followed by a 1-week "patch free" period.

Levora

oral contraceptive containing 150mcg of LNG and 30mcg of EE

Group Type ACTIVE_COMPARATOR

Levora

Intervention Type DRUG

One tablet of Levora will be taken each day for a 28 day cycle.

Interventions

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AG200-15

Contraception; AG200-15 is applied and replaced every 7 days for 3 weeks, followed by a 1-week "patch free" period.

Intervention Type DRUG

Levora

One tablet of Levora will be taken each day for a 28 day cycle.

Intervention Type DRUG

Other Intervention Names

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Transdermal contraceptive delivery system (TCDS) Hormonal oral contraceptive

Eligibility Criteria

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Inclusion Criteria

* sexually active women requesting contraception
* Regular menses every 24 - 35 days
* In good general health, confirmed by medical history, physical (including gynecologic examination adn screening laboratory values

Exclusion Criteria

* Known or suspected pregnancy
* Lactating women
* Significant skin reaction to transdermal preparations or sensitivity to surgical / medical tape
* Any disease that may worsen under hormonal treatment (cardiovascular, liver, metabolic)
* Use of other contraceptive methods than study medication
Minimum Eligible Age

18 Years

Maximum Eligible Age

40 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

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Agile Therapeutics

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Marie Foegh, MD

Role: STUDY_DIRECTOR

Agile Therapeutics

Locations

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Mobile, Alabama, United States

Site Status

Green Valley, Arizona, United States

Site Status

Tucson, Arizona, United States

Site Status

Los Angeles, California, United States

Site Status

Los Angeles, California, United States

Site Status

West Hills, California, United States

Site Status

Boynton Beach, Florida, United States

Site Status

South Miami, Florida, United States

Site Status

St. Petersburg, Florida, United States

Site Status

Newburgh, Indiana, United States

Site Status

Louisville, Kentucky, United States

Site Status

Las Vegas, Nevada, United States

Site Status

Las Vegas, Nevada, United States

Site Status

Kernersville, North Carolina, United States

Site Status

Englewood, Ohio, United States

Site Status

Tulsa, Oklahoma, United States

Site Status

Mt. Pleasant, South Carolina, United States

Site Status

Corpus Christi, Texas, United States

Site Status

Sugar Land, Texas, United States

Site Status

Newport News, Virginia, United States

Site Status

Norfolk, Virginia, United States

Site Status

Countries

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United States

Other Identifiers

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ATI-CL13

Identifier Type: -

Identifier Source: org_study_id

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