Study to Investigate Compliance With the Oral Contraceptive SH T00186D in a Flexible Extended Regimen Supported by a Dispenser With a Reminder Function

NCT ID: NCT01257984

Last Updated: 2014-10-28

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

508 participants

Study Classification

INTERVENTIONAL

Study Start Date

2010-12-31

Study Completion Date

2012-09-30

Brief Summary

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The objective of the study is to evaluate the effect of the dispenser's buzzer function on compliance with daily tablet intake of an ethinyl estradiol (EE) + drospirenone (DRSP) containing oral contraceptive (OC) in a flexible extended regimen when administered for approximately 12 months to healthy female volunteers who request contraception.

Detailed Description

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Conditions

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Contraception

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Arm 1

Group Type EXPERIMENTAL

BAY86-5300

Intervention Type DRUG

0.02 mg EE as ß-CDC / 3 mg DRSP in a tablet form (1 tablet/day) for up to 120 days, followed by a 4-day tablet-free interval, administered with a dispenser supported by a reminder function

Arm 2

Group Type EXPERIMENTAL

BAY86-5300

Intervention Type DRUG

0.02 mg EE as ß-CDC / 3 mg DRSP in a tablet form (1 tablet/day) for up to 120 days, followed by a 4-day tablet-free interval, administered with a dispenser without reminder support

Interventions

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BAY86-5300

0.02 mg EE as ß-CDC / 3 mg DRSP in a tablet form (1 tablet/day) for up to 120 days, followed by a 4-day tablet-free interval, administered with a dispenser supported by a reminder function

Intervention Type DRUG

BAY86-5300

0.02 mg EE as ß-CDC / 3 mg DRSP in a tablet form (1 tablet/day) for up to 120 days, followed by a 4-day tablet-free interval, administered with a dispenser without reminder support

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Healthy female volunteers between 18 and 35 years of age (smokers up to 30 years, inclusive) who request contraceptive protection

Exclusion Criteria

* Pregnancy or lactation (less than 3 months since delivery, abortion, or lactation before start of treatment)
* Body mass index (BMI) \>/= 30.0 kg/m2
* Presence or a history of venous or arterial thrombotic/thromboembolic events
* Repeated measurements of systolic blood pressure \> 140 mmHg and/or diastolic blood pressure \> 90 mmHg.
* Presence or history of liver tumors (benign or malignant), severe hepatic disease, jaundice and/or pruritus related to cholestasis, cholestatic jaundice associated with pregnancy or previous COC use
* Uncontrolled diabetes mellitus and/or diabetes mellitus with vascular involvement
* Severe dyslipoproteinemia
* Malignant or premalignant disease
* Uncontrolled thyroid disorder
* Chronic inflammatory bowel disease
* Severe renal insufficiency or acute renal failure
* History of migraine with focal neurologic symptoms
* Epilepsy
Minimum Eligible Age

18 Years

Maximum Eligible Age

35 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

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Bayer

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Bayer Study Director

Role: STUDY_DIRECTOR

Bayer

Locations

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Paris, Paris, France

Site Status

Biarritz, , France

Site Status

Marly-le-Roi, , France

Site Status

Nancy, , France

Site Status

Olivet, , France

Site Status

Paris, , France

Site Status

Paris, , France

Site Status

Paris, , France

Site Status

Strasbourg, , France

Site Status

Toulouse, , France

Site Status

Heidelberg, Baden-Wurttemberg, Germany

Site Status

Hamburg, City state of Hamburg, Germany

Site Status

Frankfurt am Main, Hesse, Germany

Site Status

Wuppertal, North Rhine-Westphalia, Germany

Site Status

Blankenburg, Saxony-Anhalt, Germany

Site Status

Burg, Saxony-Anhalt, Germany

Site Status

Magdeburg, Saxony-Anhalt, Germany

Site Status

Gera, Thuringia, Germany

Site Status

Kahla, Thuringia, Germany

Site Status

Bologna, , Italy

Site Status

Brescia, , Italy

Site Status

Cagliari, , Italy

Site Status

Catania, , Italy

Site Status

Milan, , Italy

Site Status

Modena, , Italy

Site Status

Napoli, , Italy

Site Status

Palermo, , Italy

Site Status

Pavia, , Italy

Site Status

Pisa, , Italy

Site Status

Roma, , Italy

Site Status

Siena, , Italy

Site Status

Elda, Alicante, Spain

Site Status

Barcelona, Barcelona, Spain

Site Status

Córdoba, Córdoba, Spain

Site Status

Boadilla del Monte, Madrid, Spain

Site Status

Málaga, Málaga, Spain

Site Status

Chesterfield, Derbyshire, United Kingdom

Site Status

Nottingham, Nottinghamshire, United Kingdom

Site Status

Bath, Somerset, United Kingdom

Site Status

East Horsley, Surrey, United Kingdom

Site Status

Bradford-on-Avon, Wiltshire, United Kingdom

Site Status

Corsham, Wiltshire, United Kingdom

Site Status

Cardiff, , United Kingdom

Site Status

Countries

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France Germany Italy Spain United Kingdom

Related Links

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http://www.clinicaltrialsregister.eu/

Click here to find information about studies related to Bayer Healthcare products conducted in Europe

Other Identifiers

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2010-019902-17

Identifier Type: EUDRACT_NUMBER

Identifier Source: secondary_id

14701

Identifier Type: -

Identifier Source: org_study_id

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