A Research Study Looking at Specific Tissue of the Umbilical Cord

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

64 participants

Study Classification

OBSERVATIONAL

Study Start Date

2010-06-30

Study Completion Date

2016-07-31

Brief Summary

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The purpose of this study is to isolate Umbilical cord Wharton's jelly matrix to be used as a scaffold for tissue regenerative applications, including avascular necrosis.

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Detailed Description

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Our working hypothesis is that umbilical cord blood Wharton's Jelly matrix has all the biochemical and biomechanical characteristics needed in an ideal scaffold for tissue engineering. Accordingly, we expect matrix to support the growth and differentiation of transplanted mesenchymal stem cells. The first step in this effort is to isolate Wharton's Jelly matrix by decellularization. The second step will be to test the ability of this matrix to support the growth and differentiation of transplanted mesenchymal stem cells. The third step will be to pursue preliminary animal testing to study the ability of this matrix to support bone tissue regeneration in vivo.

Conditions

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Varices of Umbilical Cord

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Study Groups

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Umbilical cord

To isolate Umbilical cord Wharton's jelly matrix to be used as a scaffold for tissue regenerative applications, including avascular necrosis.

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Pregnant Women
* 18 years of age or older
* willing to donate umbilical cord units

Exclusion Criteria

* less than 18 years of age
* Has Hepatitis or HIV
* Considered High Risk
* Scheduled for C-Section due to complications during current pregnancy
* Delivered prior to Full Term

Minimum Eligible Age

18 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes