TX2® Low Profile TAA Endovascular Graft

NCT ID: NCT01151020

Last Updated: 2021-01-22

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

View full results

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

110 participants

Study Classification

INTERVENTIONAL

Study Start Date

2010-03-31

Study Completion Date

2018-05-11

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The Zenith® TX2® Low Profile TAA Endovascular Graft study is a clinical trial approved by US FDA to evaluate the safety and effectiveness of the Zenith® TX2® Low Profile TAA Endovascular Graft indicated for the treatment of patients with aneurysms/ulcers of the descending thoracic aorta having vessel structure suitable for repair.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Aortic Aneurysm Penetrating Ulcer Vascular Disease

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Arm 1

Zenith® TX2® Low Profile TAA Endovascular Graft (Thoracic Aortic Aneurysm)

Group Type EXPERIMENTAL

Zenith® TX2® Low Profile TAA Endovascular Graft

Intervention Type DEVICE

Endovascular treatment of patients with aneurysms/ulcers of the descending thoracic aorta having morphology suitable for endovascular repair

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Zenith® TX2® Low Profile TAA Endovascular Graft

Endovascular treatment of patients with aneurysms/ulcers of the descending thoracic aorta having morphology suitable for endovascular repair

Intervention Type DEVICE

Other Intervention Names

Discover alternative or legacy names that may be used to describe the listed interventions across different sources.

Zenith Alpha Thoracic™ Endovascular Graft TEVAR

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Descending thoracic aneurysm with diameter ≥ 5.0 cm
* Descending thoracic aneurysm with a history of growth ≥ 0.5 cm per year
* Descending thoracic degenerative or atherosclerotic ulcer ≥ 10 mm in depth and 20 mm in diameter

Exclusion Criteria

* Less than 18 years of age
* Life expectancy less than 2 years
* Pregnant or breastfeeding or planning on becoming pregnant within 60 months
* Unwilling to comply with the follow-up schedule
* Inability or refusal to give informed consent
* Less than 30 days beyond primary endpoint for other investigative drug or device study
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Cook Research Incorporated

INDUSTRY

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Responsibility Role SPONSOR

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

Karl Illig, MD

Role: PRINCIPAL_INVESTIGATOR

University of South Florida

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

Kaiser Permanente

San Francisco, California, United States

Site Status

Washington Hospital Center

Washington D.C., District of Columbia, United States

Site Status

University of South Florida

Tampa, Florida, United States

Site Status

Emory University

Atlanta, Georgia, United States

Site Status

Methodist Hospital of Indiana

Indianapolis, Indiana, United States

Site Status

Indiana Heart Hospital

Indianapolis, Indiana, United States

Site Status

University of Michigan

Ann Arbor, Michigan, United States

Site Status

Mayo Clinic Rochester

Rochester, Minnesota, United States

Site Status

Barnes-Jewish Hospital

St Louis, Missouri, United States

Site Status

Dartmouth Hitchcock Medical Center

Lebanon, New Hampshire, United States

Site Status

Cooper University Hospital

Camden, New Jersey, United States

Site Status

Hackensack University Medical Center

Hackensack, New Jersey, United States

Site Status

New York University Hospital

New York, New York, United States

Site Status

Mount Sinai Hospital

New York, New York, United States

Site Status

University of North Carolina

Chapel Hill, North Carolina, United States

Site Status

Duke University Medical Center

Durham, North Carolina, United States

Site Status

Cleveland Clinic Foundation

Cleveland, Ohio, United States

Site Status

Ohio State University

Columbus, Ohio, United States

Site Status

Hospital of the University of Pennsylvania

Philadelphia, Pennsylvania, United States

Site Status

Tennessee Baptist Memorial Hospital

Memphis, Tennessee, United States

Site Status

Inova Fairfax Hospital

Falls Church, Virginia, United States

Site Status

Harborview Medical Center

Seattle, Washington, United States

Site Status

Hannover Medical School

Hanover, , Germany

Site Status

St. Franziskus Hospital

Münster, , Germany

Site Status

Klinikum Nürnberg Sud

Nuremberg, , Germany

Site Status

Uniklinik Regensburg

Regensburg, , Germany

Site Status

University Hospital Rostock

Rostock, , Germany

Site Status

Hospital San Raffaele

Milan, , Italy

Site Status

Morinomiya Hospital

Osaka, , Japan

Site Status

Jikei University School of Medicine

Tokyo, , Japan

Site Status

Keio University Hospital

Tokyo, , Japan

Site Status

Malmö University Hospital

Malmo, , Sweden

Site Status

St.George's Hospital

London, , United Kingdom

Site Status

Countries

Review the countries where the study has at least one active or historical site.

United States Germany Italy Japan Sweden United Kingdom

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

10-001

Identifier Type: -

Identifier Source: org_study_id

NCT00923754

Identifier Type: -

Identifier Source: nct_alias

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.

Zenith® Low Profile AAA Endovascular Graft
NCT02557659 NO_LONGER_AVAILABLE
Thoracoabdominal Aortic Aneurysms
NCT06267573 NOT_YET_RECRUITING