Hair Cortisol and Testosterone in Heart Failure

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Total Enrollment

46 participants

Study Classification

OBSERVATIONAL

Study Start Date

2010-08-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The purpose of this study is to determine whether hair cortisol and testosterone levels correlate with heart failure status in patient with chronic congestive heart failure.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Multihormonal Deficiencies and miRNA Profile in Chronic Heart Failure: Effects of Combined Hormonal Replacement Therapy

NCT05769387

Patients With Ischemic or Idiopathic Dilated Cardiomyopathy

COMPLETED

The Role of Stress in Cardiac Arrest (Cortizol CPR)

NCT07285915

Chronic Stress Cardiac Arrest (CA) Post-Resuscitation Syndrome +1 more

NOT_YET_RECRUITING NA

Cardiovascular Status in Adrenal Insufficiency

NCT03426319

Adrenal Insufficiency

COMPLETED

Circadian Function and Cardio-metabolic Risk in Adrenal Insufficiency

NCT03000231

Adrenal Insufficiency

COMPLETED

The Effect of High Dose Glucocorticoid Steroids on Myocardial Function

NCT04649294

High-dose Steroids, Myocardial Function, Longitudinal Strain

COMPLETED

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Progression of chronic congestive heart failure (CHF) is associated with abnormal secretion of several hormones including glucocorticoids and testosterone.

A single study of patients with chronic heart failure has demonstrated that higher serum levels of cortisol are independent predictors of increased mortality risk. However, this study included patients with heart failure who were admitted to the hospital due to other causes and it might be speculated that the single serum cortisol measurement taken may have been influenced by the acute illness or by the emotional stress associated with the admission itself.

Currently, there are several modalities for measuring cortisol levels including serum, urinary and salivary techniques. However, all these methods represent indicators of acute cortisol secretion and do not reflect accumulation of the hormone over time. Recently there has been a growing interest in measuring hair cortisol level. Hair grows approximately 1 centimeter per month and therefore hair analysis accurately reflects long-term endogenous production of cortisol. This provides for the first time a reliable mode for the measurement of the accumulation of cortisol over time. We have recently demonstrated higher hair cortisol levels in patients with acute myocardial infarction compared with controls (the manuscript has been submitted for publication). Regarding testosterone, several studies have recently demonstrated lower free serum testosterone levels in patients with heart failure compared with controls. Furthermore, Serum testosterone levels were inversely correlated with heart failure status.

The longitudinal assessment of cortisol and testosterone levels over time using the hair technique may be superior to a single random serum sample for the assessment of chronic heart failure status and prognosis.

If indeed, hair cortisol and testosterone levels would correlate with heart failure status, they may be used as a quantitative mode for clinical follow-up of CHF patients (similar to the role of HbA1C in the follow-up of diabetic patients). However this hypothesis has not yet been evaluated

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Systolic Heart Failure

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Patients with systolic heart failure

Patients with systolic heart failure defined as ejection fraction \<45%

Hair sampling

Intervention Type OTHER

Hair sampling for the measurement of cortisol and testosterone

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Hair sampling

Hair sampling for the measurement of cortisol and testosterone

Intervention Type OTHER

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Males
* Age \>18
* Left ventricular (LV) systolic function (EF\<45 per echocardiography)

Exclusion Criteria

* Any corticosteroid treatment in the last 6 months
* Any treatment with testosterone in the last 6 months
* Diagnosis or Cushing's or Addison's disease
* Any hospital admission within 3 months prior to enrollment
* Inability to sign inform consent
* Patients with moderate or severe aortic stenosis
* Inability to provide 3 cm hair sample from vertex posterior.
* Dyed hair
* Morbid obesity (BMI\>35)
* Any symptomatic chronic lung disease

Minimum Eligible Age

18 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

No