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The Role of Stress in Cardiac Arrest (Cortizol CPR)

NCT ID: NCT07285915

Last Updated: 2025-12-16

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Clinical Phase

NA

Total Enrollment

136 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-12-10

Study Completion Date

2027-10-31

Brief Summary

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The aim of this study is to assess long-term stress in patients after an out-of-hospital cardiac arrest. To do this, we will measure levels of the stress hormone cortisol in hair samples. Cortisol is produced in larger amounts during periods of ongoing stress and builds up in the hair as it grows. Because hair grows about 1 cm per month, a 3 cm hair sample can show your average stress level over the past three months. The results will be compared with anonymized information from your medical records and the care you received before and during your hospital stay.

Detailed Description

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Despite significant advances in resuscitation medicine, out-of-hospital cardiac arrest (OHCA) continues to carry a poor prognosis, with survival accompanied by good neurological outcomes in only about 30% of cases. In Europe, OHCA affects approximately 67-170 individuals per 100,000 annually; in the Czech Republic, the incidence is around 90 per 100,000. Most cardiac arrests (60-70%) are of cardiovascular origin, where long-term stress is a known contributing risk factor.

Chronic stress not only influences the development of cardiovascular disease but also affects its clinical manifestation by modulating the autonomic nervous system-an essential regulator of heart rhythm and arrhythmogenic risk. Therefore, it is plausible that prolonged stress also contributes to the onset and course of cardiac arrest.

While the relationship between chronic stress and cardiovascular disease has been well documented, data specifically linking stress to out-of-hospital cardiac arrest are still lacking. The pathophysiological factors influencing the onset and refractoriness of OHCA also remain unclear.

This study aims to evaluate chronic stress levels in patients after OHCA by measuring cortisol concentrations in hair samples. Since cortisol accumulates in hair during its growth, a 3 cm segment reflects stress exposure over the previous three months. These findings will be correlated with patients' demographic and clinical profiles, including post-resuscitation condition severity, neurological outcomes, and potential arrest refractoriness.

Conditions

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Chronic Stress Cardiac Arrest (CA) Post-Resuscitation Syndrome Heart Attack

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

SCREENING

Blinding Strategy

NONE

Study Groups

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Cardiac arrest

Cardiac arrest

Group Type EXPERIMENTAL

Sample of hair

Intervention Type DIAGNOSTIC_TEST

Sampling of 3cm of hair due to level of cortizol.

Heart attack

Heart attack

Group Type EXPERIMENTAL

Sample of hair

Intervention Type DIAGNOSTIC_TEST

Sampling of 3cm of hair due to level of cortizol.

Interventions

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Sample of hair

Sampling of 3cm of hair due to level of cortizol.

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* Cardiac arrest
* Heart attack
* 18 - 100 years

Exclusion Criteria

* Disapproval patient´s relatives with the study
* Chronical treatment with corticoids and antidepresives
Minimum Eligible Age

18 Years

Maximum Eligible Age

100 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University Hospital Pilsen

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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University Hospital Pilsen

Pilsen, Czech Republic, Czechia

Site Status

Countries

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Czechia

Central Contacts

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Jana Smalcova, MD, Ph.D.

Role: CONTACT

[email protected]
775 360 017 ext. +420

Milan Hromadka, MD, Ph.D.

Role: CONTACT

[email protected]
377 105 840 ext. +420

Facility Contacts

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Jana Smalcova, MD, Ph.D.

Role: primary

[email protected]
775 360 017 ext. +420

Milan Hromadka, MD, Ph.D.

Role: backup

[email protected]
377 105 840 ext. +420

Other Identifiers

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Stress

Identifier Type: -

Identifier Source: org_study_id