Role of Diaphragm Fatigue in Weaning From Mechanical Ventilation

NCT ID: NCT01135121

Last Updated: 2015-06-10

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

20 participants

Study Classification

OBSERVATIONAL

Study Start Date

2010-05-31

Study Completion Date

2016-01-31

Brief Summary

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The purpose of this study is to determine whether the diaphragm develops contractile fatigue during a weaning trial and if this is associated with weaning failure.

Detailed Description

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Conditions

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Weaning Respiratory Muscle Function

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Weaning failure

No interventions assigned to this group

Weaning succes

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* age \> 18 year
* mechanical ventilation for at least 3 days
* the treating physician judges the patient to be ready to be weaned from the ventilator
* informed consent

Exclusion Criteria

* pre-existent muscle disease (congenital or acquired) or diseases / disorders know to be associated with myopathy including auto-immune diseases.
* upper airway / esophageal pathology (i.e. recent surgery, esophageal varices, diaphragmatic hernia)
* recent (\< 1 month) nasal bleeding
* phrenic nerve lesions
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University Medical Center Nijmegen

OTHER

Sponsor Role lead

Responsible Party

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Leo Heunks

MD PhD

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Radboud University Nijmegen Medical Center

Nijmegen, Gelderland, Netherlands

Site Status RECRUITING

Countries

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Netherlands

Central Contacts

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Leo Heunks, MD, PhD

Role: CONTACT

+31 24 3617273

Facility Contacts

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Leo Heunks, MD, PhD

Role: primary

+31 24 3617273

Other Identifiers

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Wean1

Identifier Type: -

Identifier Source: org_study_id

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