The Effect and Mechanisms of the Second-meal Phenomenon in Type 2 Diabetic Patients
NCT ID: NCT01127997
Last Updated: 2010-08-23
Study Results
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Basic Information
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COMPLETED
12 participants
OBSERVATIONAL
2010-03-31
2010-08-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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CASE_CONTROL
CROSS_SECTIONAL
Study Groups
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study A
post-breakfast meal tolerance test + post-lunch meal tolerance test
No interventions assigned to this group
study B
fasting + post-lunch meal tolerance test
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
* HbA1c 6-8%
* DM duration less than 5 yrs
Exclusion Criteria
* patients using insulin, TZDs
* patients using corticosteroid, herb medication or other medications affecting glucose tolerance
* renal dysfunction (Cr \> 1.5mg/dL)
* hepatic dysfunction (LFT \> x 3UNL)
* anemia (Hg \< 10g/dL)
* ischemic heart disease, congestive heart failure
* severe diabetic complication (CRF, CVA, PDR, gastroparesis)
* infectious disease
* malignancy
* pregnant women
35 Years
70 Years
ALL
No
Sponsors
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The Catholic University of Korea
OTHER
Responsible Party
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The Catholic University of Korea
Locations
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St. Vincent's hospital
Suwon, Kyounggi-do, South Korea
Countries
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References
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Jovanovic A, Leverton E, Solanky B, Ravikumar B, Snaar JE, Morris PG, Taylor R. The second-meal phenomenon is associated with enhanced muscle glycogen storage in humans. Clin Sci (Lond). 2009 Jul 2;117(3):119-27. doi: 10.1042/CS20080542.
Bonuccelli S, Muscelli E, Gastaldelli A, Barsotti E, Astiarraga BD, Holst JJ, Mari A, Ferrannini E. Improved tolerance to sequential glucose loading (Staub-Traugott effect): size and mechanisms. Am J Physiol Endocrinol Metab. 2009 Aug;297(2):E532-7. doi: 10.1152/ajpendo.00127.2009. Epub 2009 Jun 16.
Jovanovic A, Gerrard J, Taylor R. The second-meal phenomenon in type 2 diabetes. Diabetes Care. 2009 Jul;32(7):1199-201. doi: 10.2337/dc08-2196. Epub 2009 Apr 14.
Lee SH, Tura A, Mari A, Ko SH, Kwon HS, Song KH, Yoon KH, Lee KW, Ahn YB. Potentiation of the early-phase insulin response by a prior meal contributes to the second-meal phenomenon in type 2 diabetes. Am J Physiol Endocrinol Metab. 2011 Nov;301(5):E984-90. doi: 10.1152/ajpendo.00244.2011. Epub 2011 Aug 9.
Other Identifiers
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VC10EISI0007
Identifier Type: -
Identifier Source: org_study_id
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