Cardiovascular Diseases in HIV-infected Subjects (HIV-HEART Study)

NCT ID: NCT01119729

Last Updated: 2010-05-10

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

803 participants

Study Classification

OBSERVATIONAL

Brief Summary

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Human immunodeficiency virus (HIV) infection has been associated with a variety of cardiovascular diseases. Even most industrialised countries exhibit a growing and aging population of HIV-infected patients in the majority treated with antiretroviral drugs, the investigators still do not know much about the impact of cardiovascular diseases in this group of patients. The present study is an ongoing trial that was conducted as a prospective and multicentre survey, being schemed to analyse the frequency and clinical course of cardiac disorders in HIV-infected patients.

Detailed Description

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Conditions

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Detection of Frequency, Severity and Progression of Cardiovascular Diseases in Patients With HIV-infection. Effect on Cardiovascular Risk and Life Quality by Age, Gender, Classic Cardiovascular Risk Factors, HIV-specific Cardiovascular Risk Factors, Cardiovascular Medication, Antiretroviral Medication

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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HIV-infected Outpatients

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Age \> 18 years
* Known HIV-infection
* Outpatients
* Written informed consent

Exclusion Criteria

● Acute cardiovascular disease or unstable hemodynamic status in the three weeks before inclusion

• Pregnancy
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Federal Ministry of Education and Reserach (BMBF)

UNKNOWN

Sponsor Role collaborator

University Hospital, Essen

OTHER

Sponsor Role lead

Responsible Party

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Competence Network of Heart Failure

Locations

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Department of Dermatology, University Hospital of Bochum

Bochum, North Rhine-Westphalia, Germany

Site Status

HIV Outpatient Department

Dortmund, North Rhine-Westphalia, Germany

Site Status

HIV Outpatients Department

Duisburg, North Rhine-Westphalia, Germany

Site Status

HIV Outpatient Department

Duisburg, North Rhine-Westphalia, Germany

Site Status

Department of Dermatology, University Hospital of Essen

Essen, North Rhine-Westphalia, Germany

Site Status

West German Heart Center Essen

Essen, North Rhine-Westphalia, Germany

Site Status

HIV Outpatient Department

Essen, North Rhine-Westphalia, Germany

Site Status

Countries

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Germany

References

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Neumann T, Esser S, Potthoff A, Pankuweit S, Neumann A, Breuckmann F, Neuhaus K, Kondratieva J, Buck T, Muller-Tasch T, Wachter R, Prettin C, Gelbrich G, Herzog W, Pieske B, Rauchhaus M, Loffler M, Maisch B, Mugge A, Wasem J, Gerken G, Brockmeyer NH, Erbel R; HIV-HEART Study Investigative Group. Prevalence and natural history of heart failure in outpatient HIV-infected subjects: rationale and design of the HIV-HEART study. Eur J Med Res. 2007 Jun 27;12(6):243-8.

Reference Type BACKGROUND
PMID: 17666313 (View on PubMed)

Neumann T. [HIV, AIDS and the cardiovascular risk]. Internist (Berl). 2008 Apr;49(4):429-30, 432-5. doi: 10.1007/s00108-008-2049-4. German.

Reference Type RESULT
PMID: 18305915 (View on PubMed)

Reinsch N, Buhr C, Krings P, Kaelsch H, Kahlert P, Konorza T, Neumann T, Erbel R; Competence Network of Heart Failure. Effect of gender and highly active antiretroviral therapy on HIV-related pulmonary arterial hypertension: results of the HIV-HEART Study. HIV Med. 2008 Aug;9(7):550-6. doi: 10.1111/j.1468-1293.2008.00602.x. Epub 2008 Jun 28.

Reference Type RESULT
PMID: 18557952 (View on PubMed)

Reinsch N, Buhr C, Krings P, Kaelsch H, Neuhaus K, Wieneke H, Erbel R, Neumann T; German Heart Failure Network. Prevalence and risk factors of prolonged QTc interval in HIV-infected patients: results of the HIV-HEART study. HIV Clin Trials. 2009 Jul-Aug;10(4):261-8. doi: 10.1310/hct1004-261.

Reference Type RESULT
PMID: 19723613 (View on PubMed)

Neumann T, Reinsch N, Neuhaus K, Brockmeyer N, Potthoff A, Esser S, Hower M, Neumann A, Mostardt S, Gelbrich G, Erbel R; fur die HIV-HEART-Studie sowie die Kompetenznetze Herzinsuffizienz und HIV/AIDS. [BNP in HIV-infected patients]. Herz. 2009 Dec;34(8):634-40. doi: 10.1007/s00059-009-3313-7. German.

Reference Type RESULT
PMID: 20024643 (View on PubMed)

Reinsch N, Esser S, Gelbrich G, Brockmeyer N, Potthoff A, Schadendorf D, Erbel R, Neumann T. Valvular manifestations of human immunodeficiency virus infection--results from the prospective, multicenter HIV-HEART study. J Cardiovasc Med (Hagerstown). 2013 Oct;14(10):733-9. doi: 10.2459/JCM.0b013e32835dc953.

Reference Type DERIVED
PMID: 24335884 (View on PubMed)

Esser S, Gelbrich G, Brockmeyer N, Goehler A, Schadendorf D, Erbel R, Neumann T, Reinsch N. Prevalence of cardiovascular diseases in HIV-infected outpatients: results from a prospective, multicenter cohort study. Clin Res Cardiol. 2013 Mar;102(3):203-13. doi: 10.1007/s00392-012-0519-0. Epub 2012 Nov 2.

Reference Type DERIVED
PMID: 23117698 (View on PubMed)

Reinsch N, Kahlert P, Esser S, Sundermeyer A, Neuhaus K, Brockmeyer N, Potthoff A, Erbel R, Buck T, Neumann T. Echocardiographic findings and abnormalities in HIV-infected patients: results from a large, prospective, multicenter HIV-heart study. Am J Cardiovasc Dis. 2011;1(2):176-84. Epub 2011 Jul 30.

Reference Type DERIVED
PMID: 22254197 (View on PubMed)

Other Identifiers

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FKZ 01GI0205

Identifier Type: -

Identifier Source: org_study_id

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