Third International Study on Mechanical Ventilation

NCT ID: NCT01093482

Last Updated: 2018-03-01

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 8151 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2010-04-30
• Study Completion Date: 2010-09-30

Brief Summary

The objective of this study is to obtain a better understanding of the spectrum of use of mechanical ventilation in intensive care units:

1. Main analysis: To know the all-cause mortality rate in mechanically ventilated patients

2. Secondary analyses:

• To know the current status of mechanical ventilation in the intensive care unit and determine the number and percentage of patients who are admitted to an intensive care unit and require mechanical ventilation.
• To compare the results with prior data collected in previous observational studies (1998 and 2004)
• Non-invasive positive pressure ventilation
• Weaning
• Use of adjuvant therapies as steroids or selective digestive decontamination
• Sedation including prevalence of delirium in mechanically ventilated patients
• Prediction of the duration of mechanical ventilation
• Other

Detailed Description

Mechanical ventilation is commonly used in patients admitted to intensive care units. Clinical studies have investigated some of the aspects associated with its utilization, and have contributed to improve the knowledge and management of patients with acute respiratory failure. In 1998 the invesgtigators conducted the first international study on mechanical ventilation, including 5183 patients who were mechanically ventilated longer than 12 hours (Esteban A. JAMA 2002). Six years later, the investigators carried out the second international study on mechanical ventilation including 4968 patients. These studies allowed us to analyze the evolution of mechanical ventilation and to judge the concordance of practice with results of randomized trials (Esteban A. Am J Respir Crit Care 2008). The main finding of this study was the high degree of concordance between observed changes in mechanical ventilation practice and changes predicted from reports of randomized controlled trials. However, despite apparently beneficial changes in ventilatory practice, the investigators were not able to detect significant differences in clinical outcomes over this time period. Our results serve as an updated benchmark on the usual care and outcomes of mechanically ventilated patients in a 'real-world' setting.

The investigators now propose to conduct a third international study of mechanical ventilation, 6 years after the 2nd study and 12 years after the original. This will again be a prospective, multicenter single-cohort study, which will enroll consecutive patients who have received mechanical ventilation for at least 12 hours during a 1-month period, and will follow each patient for the duration of mechanical ventilation, up to 28 days. With this 3rd study the investigators aim: 1) to determine if the observed changes that the investigators reported previously are maintained over time; 2) to evaluate if the changes implemented have impacted outcomes; 3) to analyze some aspects related to withdrawal of mechanical ventilation; and implementation non-invasive positive pressure ventilation; and 4) to evaluate what differences may occur between geographical areas.

Conditions

Acute Respiratory Failure

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Study Groups

mechanically ventilated patients

1. Patients who are admitted to the participating intensive care units and require invasive mechanical ventilation (endotracheal tube or tracheostomy) for more than 12 hours.

2. Patients who are admitted to the participating intensive care units and require non-invasive mechanical ventilation (Bilevel positive airway pressure (BIPAP) or continuous positive airway pressure (CPAP) with nasal or facial mask) for more than 1 hour.

No interventions assigned to this group

Eligibility Criteria

Inclusion Criteria

• Patients who are admitted to the intensive care unit and require invasive mechanical ventilation (endotracheal tube or tracheostomy) for more than 12 hours.
• Patients who are admitted to the intensive care unit and require non-invasive mechanical ventilation (BIPAP or CPAP with nasal or facial mask) for more than 1 hour.

Exclusion Criteria

• Patients less than 18 years old

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Hospital Universitario Getafe

OTHER

Sponsor Role: lead

Responsible Party

Andres Esteban

MD

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Andres Esteban, MD, PhD

Role: STUDY_DIRECTOR

Hospital Universitario de Getafe, Spain

Fernando Frutos-Vivar, MD

Role: PRINCIPAL_INVESTIGATOR

Hospital Universitario de Getafe, Spain

Niall D Ferguson, MD, MsC

Role: PRINCIPAL_INVESTIGATOR

University of Toronto, Ontario, Canada

Antonio Anzueto, MD

Role: PRINCIPAL_INVESTIGATOR

University of Texas Health Science Center, San Antonio, Texas, USA

Marco González, MD

Role: PRINCIPAL_INVESTIGATOR

Clinica Medellin & Universidad Pontificia Bolivariana, Colombia

Arnaud W Thille, MD

Role: PRINCIPAL_INVESTIGATOR

AP-HP, Centre Hospitalier Albert Chenevier, Henri Mondor, Créteil, France

Konstantinos Raymondos, MD

Role: PRINCIPAL_INVESTIGATOR

Hannover Medical School

Salvatore Maggiore, MD

Role: PRINCIPAL_INVESTIGATOR

Agostino Gemelli University Hospital, Università Cattolica del Sacro Cuore, Rome, Italy

Yaseen Arabi, MD

Role: PRINCIPAL_INVESTIGATOR

King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia

Rui Moreno, MD

Role: PRINCIPAL_INVESTIGATOR

Hospital de Santo António dos Capuchos, Lisboa, Portugal

Fekri Abroug, MD

Role: PRINCIPAL_INVESTIGATOR

Fattouma Bourguiba, Monastir, Tunisia

Javier Hurtado, MD

Role: PRINCIPAL_INVESTIGATOR

Hospital de Clínicas, Montevideo, Uruguay

Fernando Rios, MD

Role: PRINCIPAL_INVESTIGATOR

Hospital A.Posadas, Buenos Aires, Argentina

Luis Soto, MD

Role: PRINCIPAL_INVESTIGATOR

Hospital Nacional del Tórax, Santiago, Chile

Damian Violi, MD

Role: PRINCIPAL_INVESTIGATOR

Hospital HIGA, Güemes, Argentina

Jasmine Board, MD

Role: PRINCIPAL_INVESTIGATOR

Alfred Hospital, Melbourne, Australia

Andrew Davies, MD

Role: PRINCIPAL_INVESTIGATOR

Alfred Hospital, Melbourne, Australia

Fredi Sandi Lora, MD

Role: PRINCIPAL_INVESTIGATOR

Hospital Obrero Número 1, La Paz, Bolivia

Marco Antonio Soares Reis, MD

Role: PRINCIPAL_INVESTIGATOR

Hospital Universitário São José, Belo Horizonte, Brazil

Bin Du, MD

Role: PRINCIPAL_INVESTIGATOR

Peking Union Medical College Hospital, Beijing, Popular Republic of China

Hans-Henrik Bülow, MD

Role: PRINCIPAL_INVESTIGATOR

Holbak, Denmark

Manuel Jibaja, MD

Role: PRINCIPAL_INVESTIGATOR

Hospital Militar de Quito, Ecuador

Dimitros Matamis, MD

Role: PRINCIPAL_INVESTIGATOR

Papageorgiou Hospital, Thessaloniki, Greece

Younsuck Koh, MD

Role: PRINCIPAL_INVESTIGATOR

Asan Medical Center, University of Ulsan, Seoul, Korea

Asisclo Villagómez, MD

Role: PRINCIPAL_INVESTIGATOR

Hospital Regional 1° de Octubre, ISSSTE, México DF, Mexico

Amine Ali Zeggwagh, MD

Role: PRINCIPAL_INVESTIGATOR

Hôpital Ibn Sina, Rabat, Morocco

Michael Kuiper, MD

Role: PRINCIPAL_INVESTIGATOR

Medical Center Leeuwarden (MCL), Leeuwarden, The Netherlands

Edward Nicolayenko, MD

Role: PRINCIPAL_INVESTIGATOR

Hospital No.1, Moscow, Russian Federation

Nicolas Nin, MD

Role: PRINCIPAL_INVESTIGATOR

Hospital Universitario de Getafe, Spain

Nahit Cakar, MD

Role: PRINCIPAL_INVESTIGATOR

Istanbul Medical Faculty, Istanbul, Turkey

Gabriel D'Empaire, MD

Role: PRINCIPAL_INVESTIGATOR

Hospital de Clinicas de Caracas, Venezuela

Locations

University of Iowa Hospitals and Clinics

Iowa City, Iowa, United States

University of Louisville School of Medicine

Louisville, Kentucky, United States

Boston Medical Center

Boston, Massachusetts, United States

Baystate Medical Center

Springfield, Massachusetts, United States

Henry Ford Hospital Detroit

Detroit, Michigan, United States

Omaha VA Medical Center

Omaha, Nebraska, United States

Morristown Medical Center

Morristown, New Jersey, United States

UMDNJ-New Jersey Medical School

Newark, New Jersey, United States

The Mount Sinai Medical Center

New York, New York, United States

Bronx Lebanon Hospital Center

New York, New York, United States

New York Methodist Hospital

New York, New York, United States

Oklahoma City VA Medical Center

Oklahoma City, Oklahoma, United States

Oklahoma University Health Science Center & VA medical Center

Oklahoma City, Oklahoma, United States

Vanderbilt University School Of Medicine

Nashville, Tennessee, United States

University Of Texas Medical Branch at Galveston

Galveston, Texas, United States

University Hospital San Antonio and South Texas Veterans Health Care System

San Antonio, Texas, United States

Temple Clinic, Scott & White Healthcare

Temple, Texas, United States

Medical College Of Wisconsin

Milwaukee, Wisconsin, United States

Hospital Naval Puerto Belgrano

Bahía Blanca, , Argentina

Clinica Bazterrica

Buenos Aires, , Argentina

Clínica Santa Isabel

Buenos Aires, , Argentina

Hospital A. Posadas

Buenos Aires, , Argentina

Hospital Churruca-Visca

Buenos Aires, , Argentina

Hospital Español

Buenos Aires, , Argentina

Hospital General de Agudos Bernardino Rivadavia

Buenos Aires, , Argentina

Hospital General de Agudos Dalmacio Vélez Sársfield

Buenos Aires, , Argentina

Hospital General de Agudos donación Francisco Santojanni

Buenos Aires, , Argentina

Hospital General de Agudos Juan A. Fernandez

Buenos Aires, , Argentina

Hospital General de Agudos P. Piñeiro

Buenos Aires, , Argentina

Hospital Municipal Coronel Suárez

Buenos Aires, , Argentina

Hospital Universitario, Universidad Abierta Interamericana

Buenos Aires, , Argentina

Sanatorio Anchorena

Buenos Aires, , Argentina

Sanatorio de la Trinidad

Buenos Aires, , Argentina

Sanatorio de los Arcos

Buenos Aires, , Argentina

Sanatorio Dr. Julio Méndez

Buenos Aires, , Argentina

Sanatorio Mater Dei

Buenos Aires, , Argentina

Sanatorio Otamendi y Miroli

Buenos Aires, , Argentina

Hospital Regional de Comodoro Rivadavia

Comodoro Rivadavia, , Argentina

Hospital Tránsito Cáceres de Allende

Córdoba, , Argentina

Sanatorio Allende

Córdoba, , Argentina

Hospital Zonal Francisco López Lima

General Roca, , Argentina

Hospital Interzonal General de Agudo Profesor Dr .Luis Guemes

Haedo, , Argentina

Hospital Interzonal de Agudos San Martin

La Plata, , Argentina

Hospital Privado de Comunidad

Mar del Plata, , Argentina

Hospital Central

Mendoza, , Argentina

Hospital Lagomaggiore

Mendoza, , Argentina

Hospital Universitario Austral

Pilar, , Argentina

Policlínico Atlántico del Sur

Río Gallegos, , Argentina

Hospital Regional Rio Grande

Río Grande, , Argentina

Hospital Provincial del Centenario

Rosario, , Argentina

Sanatorio de la Trinidad

San Isidro, , Argentina

Sanatorio Las Lomas

San Isidro, , Argentina

Hospital de San Luis

San Luis, , Argentina

Hospital Pablo Soria

San Salvador de Jujuy, , Argentina

Sanatorio Nuestra Señora del Rosario

San Salvador de Jujuy, , Argentina

Sanatorio Juncal

Temperley, , Argentina

Clínica Olivos

Vicente López, , Argentina

Clínica Privada de Especialidades de Villa María

Villa María, , Argentina

Calvary Wakefield Hospital

Adelaide, , Australia

Flinders Medical Center

Adelaide, , Australia

Ballarat Health Services

Ballarat, , Australia

Bendigo Hospital

Bendigo, , Australia

Mater Health Services

Brisbane, , Australia

Canberra Hospital

Canberra, , Australia

Royal Darwin Hospital

Darwin, , Australia

Barwon Health, Geelong Hospital

Geelong, , Australia

Royal Hobart Hospital

Hobart, , Australia

Liverpool Hospital

Liverpool, , Australia

Alfred Hospital

Melbourne, , Australia

Royal Melbourne Hospital

Melbourne, , Australia

St Vincent's Hospital

Melbourne, , Australia

The Northern Hospital

Melbourne, , Australia

The Western Hospital

Melbourne, , Australia

Central Gippsland Hospital

Sale, , Australia

Concord Hospital

Sydney, , Australia

Nepean Hospital

Sydney, , Australia

St George Hospital

Sydney, , Australia

St Vincent's Hospital

Sydney, , Australia

Hospital Obrero No.1

La Paz, , Bolivia

Instituto Gastroenterológico

La Paz, , Bolivia

Hospital da Baleia

Belo Horizonte, , Brazil

Hospital da Polícia Militar

Belo Horizonte, , Brazil

Hospital de Pronto Socorro Risoleta Tolentino Neves

Belo Horizonte, , Brazil

Hospital Dia e Maternidade Unimed-BH

Belo Horizonte, , Brazil

Hospital Felício Rocho

Belo Horizonte, , Brazil

Hospital Júlia Kubitschek

Belo Horizonte, , Brazil

Hospital Luxemburgo

Belo Horizonte, , Brazil

Hospital Madre Teresa

Belo Horizonte, , Brazil

Hospital Nossa Senhora Aparecida

Belo Horizonte, , Brazil

Hospital São Francisco-Setimig

Belo Horizonte, , Brazil

Hospital Universitario Sao Jose

Belo Horizonte, , Brazil

Hospital Vera Cruz

Belo Horizonte, , Brazil

Hospital Vila da Serra

Belo Horizonte, , Brazil

Hospital Santa Rita

Contagem, , Brazil

Hospital São João de Deus

Divinópolis, , Brazil

Hospital de Messejana

Fortaleza, , Brazil

Hospital Universitário Walter Cantídio

Fortaleza, , Brazil

Hospital Universitário da Universidade Federal de Juiz de Fora

Juiz de Fora, , Brazil

Hospital Vaz Monteiro

Lavras, , Brazil

Santa Casa de Misericórdia de Ouro Preto

Ouro Preto, , Brazil

Hospital Arnaldo Gavazza Filho

Ponte Nova, , Brazil

Hospital Nossa Senhora das Graças

Sete Lagoas, , Brazil

Hospital São João Batista

Viçosa, , Brazil

Queen Elizabeth II Health Sciences Centre

Halifax, Nova Scotia, Canada

William Osler Health Science Centre

Brampton, Ontario, Canada

Saint Joseph Hospital

Hamilton, Ontario, Canada

Ottawa Hospital

Ottawa, Ontario, Canada

Mount Sinai Hospital

Toronto, Ontario, Canada

Saint Michael´s Hospital

Toronto, Ontario, Canada

Sunnybrook Health Science Centre

Toronto, Ontario, Canada

Toronto General Hospital

Toronto, Ontario, Canada

Toronto Hospital Western Division

Toronto, Ontario, Canada

Toronto Western Hospital

Toronto, Ontario, Canada

Hospital de Copiapo

Copiapó, , Chile

Hospital de Coquimbo

Coquimbo, , Chile

Instituto Nacional del Tórax

Santiago, , Chile

Beijing Chaoyang Hospital

Beijing, , China

Beijing Hospital

Beijing, , China

Beijing Huaxin Hospital

Beijing, , China

Beijing TCM Hospital

Beijing, , China

Beijing Tongren Hospital

Beijing, , China

Peking Union Medical College Hospital

Beijing, , China

Peking University 3rd Hospital

Beijing, , China

PLA 304 Hospital

Beijing, , China

PLA General Hospital

Beijing, , China

PLA Navy General Hospital

Beijing, , China

Sino-Japanese Friendship Hospital

Beijing, , China

Jilin University 2nd Hospital

Changchun, , China

Sichuan Provincial Hospital

Chengdu, , China

West China Hospital

Chengdu, , China

Chongqing Medical University 1st Hospital

Chongqing, , China

Daping Hospital

Chongqing, , China

Yunnan Chuxiong People's Hospital

Chuxiong, , China

Dalian Medical University 1st Hospital

Dalian, , China

Guangdong General Hospital

Guangdong, , China

Sun Yet-Sen University 6th Hospital

Guangzhou, , China

Hainan Medical College Hospital

Haikou, , China

Hainan Provincial People's Hospital

Haikou, , China

Zhejiang Haining People's Hospital

Haining, , China

Zhejiang Tongde Hospital

Hangzhou, , China

North District Hospital

Hong Kong, , China

Pamela Youde Nethersole Eastern Hospital

Hong Kong, , China

Prince Margaret Hospital

Hong Kong, , China

Prince Of Wales Hospital

Hong Kong, , China

Queen Elizabeth Hospital

Hong Kong, , China

Kunming City 3rd People's Hospital

Kunming, , China

Kunming Medical College 1st Hospital

Kunming, , China

Nanchang University 2nd Hospital

Nanchang, , China

Southeast University Zhongda Hospital

Nanjing, , China

Nantong 1st People's Hospital

Nantong, , China

Hebei Medical University 4th Hospital

Shijiazhuang, , China

Suzhou University 1st Hospital

Suzhou, , China

Fengrun District People's Hospital

Tangshan, , China

Wuhan University Zhongnan Hospital

Wuhan, , China

Wuxi Municipal People's Hospital

Wuxi, , China

Xi'an Jiaotong University 1st Hospital

Xi'an, , China

Xuzhou Central Hospital

Xuzhou, , China

Yantai Yuhuangding Hospital

Yantai, , China

Clínica General del Norte

Barranquilla, , Colombia

Clínica Fundadores

Bogotá, , Colombia

Clínica Shaio

Bogotá, , Colombia

Grupo Cimca Hospital de San José (medical ICU)

Bogotá, , Colombia

Grupo Cimca Hospital de Suba

Bogotá, , Colombia

Grupo Cimca Hospital San José

Bogotá, , Colombia

Hospital Santa Clara

Bogotá, , Colombia

Fundación cardiovascular colombiana

Bucaramanga, , Colombia

Centro Medico Imbanaco

Cali, , Colombia

Clínica Fundación Valle Lili

Cali, , Colombia

Nuevo Hospital Bocagrande

Cartagena, , Colombia

Hospital Federico Lleras Acosta

Ibagué, , Colombia

Hospital San Rafael

Itagüí, , Colombia

Clinica Universitaria Bolivariana

Medellín, , Colombia

Clínica Cardiovascular

Medellín, , Colombia

Clínica Las Américas

Medellín, , Colombia

Clínica Medellín & Universidad Pontificia Bolivariana

Medellín, , Colombia

Corbic

Medellín, , Colombia

Hospital General de Medellín

Medellín, , Colombia

Holbak

Holbæk, , Denmark

Koge

Køge, , Denmark

Nykobing Falster

Nykøbing Falster, , Denmark

Naestved

Næstved, , Denmark

Roskilde

Roskilde, , Denmark

Slagelse

Slagelse, , Denmark

Hospital José Carrasco Arteaga

Cuenca, , Ecuador

Hospital Luis Vernaza

Guayaquil, , Ecuador

Hospital San Vicente de Paul

Ibarra, , Ecuador

Hospital Carlos Andrade Marín

Quito, , Ecuador

Hospital de la Policía

Quito, , Ecuador

Hospital de los Valles

Quito, , Ecuador

Hospital de SOLCA (ICU medical surgical & ICU medical)

Quito, , Ecuador

Hospital Enrique Garcés

Quito, , Ecuador

Hospital Eugenio Espejo

Quito, , Ecuador

Hospital General de las Fuerzas Armadas

Quito, , Ecuador

Hospital Metropolitano

Quito, , Ecuador

Hospital Pablo Arturo Suárez

Quito, , Ecuador

Cairo University Hospitals

Cairo, , Egypt

Hôpital d'Armentières

Armentières, , France

Centre Hospitalier de Châlons en Champagne

Châlons-en-Champagne, , France

CHU Henri Mondor

Créteil, , France

CHU d'Angers

d'Angers, , France

CHU De Grenoble

Grenoble, , France

Centre Hospitalier Du Mans

Le Mans, , France

Hôpital Édouard Herriot

Lyon, , France

Centre Hospitalier De Montauban

Montauban, , France

Centre Hospitalier De Roanne

Roanne, , France

CHU Charles Nicolle

Rouen, , France

Centre Hospitalier De Saint-Malo

St-Malo, , France

Katholische Stiftung Marienhospital Aachen

Aachen, , Germany

Universitaetsklinikum Aachen

Aachen, , Germany

St. Nikolaus-Stiftshospital GmbH

Andernach, , Germany

Klinikum Bad Salzungen GmbH

Bad Salzungen, , Germany

Ermstalklinik Bad Urach

Bad Urach, , Germany

Charité Universitaetsklinikum (ICU medical-surgical & ICU other)

Berlin, , Germany

Lungenklinik Heckeshorn

Berlin, , Germany

Evangelisches Waldkrankenhaus Bad Godesberg gGmbH

Bonn, , Germany

Universitaetsklinikum Bonn (ICU medical-surgical & ICU surgical)

Bonn, , Germany

Carl-Thiem-Klinikum Cottbus gGmbH

Cottbus, , Germany

Evangelisches Krankenhaus Elisabethenstift gGmbH

Darmstadt, , Germany

Universitaetsklinikum Carl Gustav Carus

Dresden, , Germany

Evangelisches Diakoniekrankenhaus

Freiburg im Breisgau, , Germany

Universitaetsklinikum der Georg-August-Universitaet

Göttingen, , Germany

Staedtisches Krankenhaus Martha-Maria Halle-Doelau gGmbH

Halle, , Germany

Allgemeines Krankenhaus Harburg

Hamburg, , Germany

Medizinische Hochschule Hannover

Hanover, , Germany

Vivantes Krankenhaus am Urban

Kreuzberg, , Germany

Staedtisches Klinikum Lueneburg

Lüneburg, , Germany

Universitaetsklinikum

Magdeburg, , Germany

Hufeland Klinikum GmbH

Mühlhausen, , Germany

Dietrich-Bonhoeffer Klinikum Neubrandenburg

Neubrandenburg, , Germany

Klinikum der Universitaet Regensburg

Regensburg, , Germany

Ermstalklinik Staedtisches Krankenhaus Sindelfingen

Sindelfingen, , Germany

Bundeswehrkrankenhaus Ulm

Ulm, , Germany

Universitaetsklinikum der Martin-Luther-Universitaet Halle-Wittenberg

Wittenberg, , Germany

Staedtisches Klinikum Wolfenbuttel

Wolfenbüttel, , Germany

Georgius-Agricola-Klinikum Zeitz

Zeitz, , Germany

Agios Pavlos General Hospital

Thessaloniki, , Greece

Ahepa Hospital

Thessaloniki, , Greece

Gennimata Hospital

Thessaloniki, , Greece

Papageorgiou Hospital

Thessaloniki, , Greece

Kenezy Hospital

Debrecen, , Hungary

University of Szeged (Four ICU)

Szeged, , Hungary

Kalinga Hospital

Bhubaneswar, , India

Apollo Hospitals

Chennai, , India

Artemis Health Institute

Gurgaon, , India

CHL Apollo Hospital

Indore, , India

Tata Main Hospital

Jamshedpur, , India

AMRI Hospitals Kolkata

Kolkata, , India

Calcutta medical research institute (CMRI)

Kolkata, , India

Calcutta Medical Research Institute

Kolkata, , India

Kasturba Medical College

Manipal, , India

Bombay Hospital Institute of Medical Sciences

Mumbai, , India

Hinduja Hospital

Mumbai, , India

Saifee Hospital

Mumbai, , India

Tata Memorial Hospital

Mumbai, , India

Ruby Hall Clinic

Pune, , India

CARE Hospitals

Surat, , India

Spandan Multispeciality Hospital

Vadodara, , India

Ospedale Policlinico, Università Di Bari

Bari, , Italy

Policlinico Universitario "S. Orsola-Malpighi"

Bologna, , Italy

Ospedale "San Giovanni Di Dio"

Florence, , Italy

Ospedale "Santa Maria Annunziata"

Florence, , Italy

Fondazione IRCCS "Cà Grande" Ospedale Maggiore Policlinico, Università Di Milano

Milan, , Italy

Ospedale "San Gerardo", Università Di Milano Bicocca

Monza, , Italy

Ospedale "V. Monaldi"

Napoli, , Italy

Ospedale Policlinico "Federico II", Università Di Napoli

Napoli, , Italy

Ospedale Maggiore Della Carità, Università Del Piemonte Orientale "Amedeo Avogadro"

Novara, , Italy

Ospedale "Arnas Civico, Di Cristina, Benfratelli"

Palermo, , Italy

Policlinico "P. Giaccone", Università Di Palermo

Palermo, , Italy

Fondazione IRCCS Policlinico "S. Matteo", Università Di Pavia (ICU 1 & ICU 2)

Pavia, , Italy

Policlinico "Agostino Gemelli", Università Cattolica Del Sacro Cuore

Roma, , Italy

Policlinico "Umberto I", Università La Sapienza

Roma, , Italy

Ospedale "San Giovanni Battista - Molinette", Università Di Torino

Torino, , Italy

Tokyo Women's Medical University

Tokyo, , Japan

Centenario Hospital Miguel Hidalgo

Aguascalientes, , Mexico

Hospital Regional de Pemex

Ciudad Madero, , Mexico

Hospital General de México

Mexico City, , Mexico

Instituto Nacional De Ciencias Médicas y Nutrición Salvador Zubirán

Mexico City, , Mexico

Hospital Mérida Yucatán

Mérida, , Mexico

Hospital Juárez de México

México DF, , Mexico

Hospital Regional 1° de Octubre, ISSSTE

México DF, , Mexico

Hospital Regional de Zona No.1 del IMSS

México DF, , Mexico

Hospital Ángeles de las Lomas

México DF, , Mexico

Instituto Nacional de Cancerología

México DF, , Mexico

Umae Hospital De Especialidades Dr. Antonio Fraga Mouret

México DF, , Mexico

Centro Médico ABC

México, DF, , Mexico

Hospital Español de México

Miguel Hidalgo, , Mexico

Hospital Universitario de Nuevo León 'Dr. Eleuterio González'

Nuevo León, , Mexico

Hospital Regional de Alta Especialidad de la Mujer

Villahermosa, , Mexico

Hôpital des Specialites

Rabat, , Morocco

Hôpital Ibn Sina (Three units)

Rabat, , Morocco

Hôpital Militaire D'Instruction Mohamed V

Rabat, , Morocco

Onze Lieve Vrouwe Gasthuis (OLVG)

Amsterdam, , Netherlands

Vrije Universiteit Medisch Centrum (VUMC) (Three units)

Amsterdam, , Netherlands

Kennemer Gasthuis

Haarlem, , Netherlands

Tjongerschans Ziekenhuis

Heerenveen, , Netherlands

Spaarneziekenhuis

Hoofddorp, , Netherlands

Medical Center Leeuwarden (MCL)

Leeuwarden, , Netherlands

Universitair Medisch Centrum Maastricht

Maastricht, , Netherlands

Medisch Centrum Haaglanden

The Hague, , Netherlands

CVICU Auckland City Hospital

Auckland, , New Zealand

DCCM Auckland City Hospital

Auckland, , New Zealand

Middlemore

Auckland, , New Zealand

Christchurch Hospital

Christchurch, , New Zealand

Waikato

Hamilton, , New Zealand

Tauranga Hospital

Tauranga, , New Zealand

Wellington Hospital

Wellington, , New Zealand

Hospital Rafael Hernández

Chiriquí, , Panama

Hospital Edgardo Rebagliatti Martins

Lima, , Peru

Hospital Guillermo Almenara Irigoyen

Lima, , Peru

Karol Marcinkowski University Of Medical Sciences

Poznan, , Poland

Hospital Garcia de Orta

Almada, , Portugal

Hospital da Luz

Amadora, , Portugal

Hospital de Cascais

Cascais, , Portugal

Centro Hospitalar de Lisboa Central

Lisbon, , Portugal

Centro Hospitalar de Lisboa Norte

Lisbon, , Portugal

Hospital de Santo Antonio dos Capuchos, Centro Hospitalar de Lisboa Central, E.P.E.

Lisbon, , Portugal

Centro Hospitalar Do Porto - Hospital Geral De Santo António

Porto, , Portugal

Instituto Português de Oncología Francisco Gentil

Porto, , Portugal

Hospital De São Sebastião

Seide, , Portugal

Centro Hospitalar Trás-Os-Montes E Alto Douro

Vila Real, , Portugal

VA Caribbean Health Care System

San Juan, PR, Puerto Rico

City Hospital Number 1 of Arkhangelsk

Arkhangelsk, , Russia

Hospital No.7

Moscow, , Russia

National Institute Of Surgery Named After A.V. Vishnevskij

Moscow, , Russia

Hospital No.14

Yekaterinburg, , Russia

King Saud Bin Abdulaziz University for Health Sciences

Riyadh, , Saudi Arabia

Hospital Korea University of Ansan

Ansan, , South Korea

Hallym University Medical Center

Anyang, , South Korea

Hospital Chungbuk National University

Cheongju-si, , South Korea

Hospital Chuncheon Sacred Heart Hospital, Hallym University Medical Center

Chuncheon, , South Korea

Hospital Catholic University of Daegu

Daegu, , South Korea

Hospital Dongguk University of Gyeongju

Gyeongju, , South Korea

Asan Medical Center, University of Ulsan

Seoul, , South Korea

Hospital Ewha Womans University Mokdong

Seoul, , South Korea

Hospital Severance, Yonsei University Health System

Seoul, , South Korea

Samsung Medical Center, Sungkyunkwan University

Seoul, , South Korea

Hospital Yonsei University Wonju Christian

Wŏnju, , South Korea

Hospital Pusan National University of Yangsan

Yangsan, , South Korea

Hospital Juan Canalejo

A Coruña, , Spain

Hospital General de Albacete

Albacete, , Spain

Hospital Príncipe de Asturias

Alcalá de Henares, , Spain

Fundación Hospital Universitario de Alcorcón

Alcorcón, , Spain

Hospital General de Alicante

Alicante, , Spain

Hospital San Juan

Alicante, , Spain

Hospital Torrecárdenas

Almería, , Spain

Hospital del Tajo

Aranjuez, , Spain

Hospital del Sureste

Arganda, , Spain

Hospital San Agustín

Avilés, , Spain

Hospital Germans Trias i Pujol

Badalona, , Spain

Hospital de Cruces

Barakaldo, , Spain

Hospital Clinic-IDIBAPS (ICU medical & ICU respiratory)

Barcelona, , Spain

Hospital de la Santa Creu y Sant Pau

Barcelona, , Spain

Hospital del Mar

Barcelona, , Spain

Hospital Sagrado Corazón

Barcelona, , Spain

Hospital SCIAS

Barcelona, , Spain

Hospital Santa María del Rosell

Cartagena, , Spain

Hospital de la Plana

Castellon, , Spain

Hospital General de Castellón

Castellon, , Spain

Hospital Provincial de Castellón

Castellon, , Spain

Hospital San Pedro de Alcántara

Cáceres, , Spain

Complejo Hospitalario de Ciudad Real

Ciudad Real, , Spain

Hospital del Henares

Coslada, , Spain

Hospital Universitario Reina Sofia

Córdoba, , Spain

Hospital de Don Benito

Don Benito, , Spain

Complejo Hospitalario de Donostia

Donostia / San Sebastian, , Spain

Hospital del Poniente

El Ejido, , Spain

Hospital General Universitario de Elche

Elche, , Spain

Hospital Arquitecto Marcide

Ferrol, , Spain

Hospital de Fuenlabrada

Fuenlabrada, , Spain

Hospital de Galdakao

Galdakao, , Spain

Hospital Universitario de Getafe

Getafe, , Spain

Hospital de Cabueñes

Gijón, , Spain

Hospital Universitario Doctor Josep Trueta

Girona, , Spain

Hospital Virgen de las Nieves

Granada, , Spain

Hospital General de Guadalajara

Guadalajara, , Spain

Hospital Juan Ramón Jimenez

Huelva, , Spain

Complejo Hospitalario de Jaen

Jaén, , Spain

Hospital General de Jerez de la Frontera

Jérez de La Frontera, , Spain

Hospital General de La Palma

La Palma, , Spain

Hospital Doctor Negrín

Las Palmas, , Spain

Hospital Insular de Gran Canaria

Las Palmas, , Spain

Complejo Hospitalario de León

León, , Spain

Hospital Arnau de Vilanova

Lleida, , Spain

Hospital de San Pedro

Logroño, , Spain

Complejo Hospitalario Xeral-Calde

Lugo, , Spain

Fundación Jiménez Díaz

Madrid, , Spain

Hospital 12 de Octubre (Trauma ICU)

Madrid, , Spain

Hospital 12 de Octubre

Madrid, , Spain

Hospital Clínico San Carlos

Madrid, , Spain

Hospital de la Princesa

Madrid, , Spain

Hospital Gregorio Marañón

Madrid, , Spain

Hospital Infanta Leonor

Madrid, , Spain

Hospital Quirón

Madrid, , Spain

Hospital Universitario de la Paz

Madrid, , Spain

Hospital Universitario Puerta de Hierro

Majadahonda, , Spain

Hospital de Mataró

Mataró, , Spain

Hospital Carlos Haya

Málaga, , Spain

Hospital Universitario Virgen de la Victoria

Málaga, , Spain

Hospital de Móstoles

Móstoles, , Spain

Hospital J .M. Morales Meseguer

Murcia, , Spain

Hospital Universitario Reina Sofia

Murcia, , Spain

Hospital Virgen de la Arrixaca

Murcia, , Spain

Hospital Vega Baja de Orihuela

Orihuela, , Spain

Complejo Hospitalario de Ourense

Ourense, , Spain

Hospital Central de Asturias

Oviedo, , Spain

Hospital Rio Carrión

Palencia, , Spain

Hospital Son Llatzer

Palma de Mallorca, , Spain

Hospital Universitario Son Espasses

Palma de Mallorca, , Spain

Complejo Hospitalario de Navarra

Pamplona, , Spain

Hospital Infanta Cristina

Parla, , Spain

Complejo Hospitalario Montecelo

Pontevedra, , Spain

Hospital Universitario de San Juan

Reus, , Spain

Hospital Parc Taulí

Sabadell, , Spain

Hospital de Sagunto

Sagunto, , Spain

Complejo Hospitalario de Salamanca

Salamanca, , Spain

Hospital Clínico de Salamanca

Salamanca, , Spain

Complejo Hospitalario de Santiago de Compostela

Santiago de Compostela, , Spain

Hospital General de Segovia

Segovia, , Spain

Hospital Universitario de Valme

Seville, , Spain

Hospital Virgen del Rocío

Seville, , Spain

Hospital General de Soria

Soria, , Spain

Hospital Mutua de Terrassa

Terrassa, , Spain

Hospital Obispo Polanco

Teruel, , Spain

Complejo Hospitalario de Toledo

Toledo, , Spain

Hospital de Torrevieja

Torrevieja, , Spain

Hospital Infanta Elena

Valdemoro, , Spain

Hospital Universitario de la Fe

Valencia, , Spain

Hospital Universitario Dr. Peset

Valencia, , Spain

Hospital Clínico de Valladolid

Valladolid, , Spain

Hospital Rio Hortega

Valladolid, , Spain

Hospital Meixoeiro

Vigo, , Spain

Hospital Santiago Apóstol

Vitoria-Gasteiz, , Spain

Hospital Lluis Alcanyis

Xàtiva, , Spain

Hospital de Zamora

Zamora, , Spain

Hospital Clínico Lozano Blesa

Zaragoza, , Spain

Hospital Royo Vilanova

Zaragoza, , Spain

Chi Mei Medical Center

Tainan City, , Taiwan

Hospital Abderrahmane Mami

Aryanah, , Tunisia

Hospital Taher Sfar City

Mahdia, , Tunisia

Hospital Fattouma Bourguina (ICU medical & ICU surgical)

Monastir, , Tunisia

CHU Habib Bourguiba

Sfax, , Tunisia

Hospital Universitarie Farhat Hached

Sousse, , Tunisia

Uludag University Faculty of Medicine

Bursa, , Turkey (Türkiye)

Erciye Üniversity

Erciyes, , Turkey (Türkiye)

Anadolu Medical Center Istanbul

Istanbul, , Turkey (Türkiye)

Atatürk Hospital

Izmir, , Turkey (Türkiye)

Sutcu İmam University

Kahramanmaraş, , Turkey (Türkiye)

Kirikkale University

Kırıkkale, , Turkey (Türkiye)

Faculty of Medicine Mersin University

Mersin, , Turkey (Türkiye)

Medical Faculty of Yuzuncu Yil University

Van, , Turkey (Türkiye)

CAAMOC Carmelo

Carmelo, , Uruguay

Orameco

Colonia del Sacramento, , Uruguay

Hospital de Florida

Florida, , Uruguay

CRAMI

Las Piedras, , Uruguay

Hospital de Maldonado

Maldonado, , Uruguay

Sanatorio Mautone

Maldonado, , Uruguay

Sanatorio CAMS

Mercedes, , Uruguay

CASMU Nº2

Montevideo, , Uruguay

Circulo Católico

Montevideo, , Uruguay

CUDAM

Montevideo, , Uruguay

Hospital de Clínicas

Montevideo, , Uruguay

Hospital Español

Montevideo, , Uruguay

Hospital Evangélico

Montevideo, , Uruguay

Hospital Maciel

Montevideo, , Uruguay

Hospital Pasteur

Montevideo, , Uruguay

Hospital Policial

Montevideo, , Uruguay

Impassa

Montevideo, , Uruguay

Sanatorio Americano

Montevideo, , Uruguay

CAAMEPA

Pando, , Uruguay

COMEPA

Paysandú, , Uruguay

Hospital Escuela del Litoral

Paysandú, , Uruguay

Sanatorio Cantegril

Punta del Este, , Uruguay

Hospital Centro de Especialidades

Anzoátegui, , Venezuela

Hospital Clínico Universitario

Caracas, , Venezuela

Hospital de Clínicas

Caracas, , Venezuela

Hospital Miguel Pérez Carreño

Caracas, , Venezuela

Viet Duc Hospital

Hanoi, , Vietnam

Countries

United States; Argentina; Australia; Bolivia; Brazil; Canada; Chile; China; Colombia; Denmark; Ecuador; Egypt; France; Germany; Greece; Hungary; India; Italy; Japan; Mexico; Morocco; Netherlands; New Zealand; Panama; Peru; Poland; Portugal; Puerto Rico; Russia; Saudi Arabia; South Korea; Spain; Taiwan; Tunisia; Turkey (Türkiye); Uruguay; Venezuela; Vietnam

References

Esteban A, Anzueto A, Frutos F, Alia I, Brochard L, Stewart TE, Benito S, Epstein SK, Apezteguia C, Nightingale P, Arroliga AC, Tobin MJ; Mechanical Ventilation International Study Group. Characteristics and outcomes in adult patients receiving mechanical ventilation: a 28-day international study. JAMA. 2002 Jan 16;287(3):345-55. doi: 10.1001/jama.287.3.345.

Reference Type: BACKGROUND

PMID: 11790214 (View on PubMed)

Esteban A, Ferguson ND, Meade MO, Frutos-Vivar F, Apezteguia C, Brochard L, Raymondos K, Nin N, Hurtado J, Tomicic V, Gonzalez M, Elizalde J, Nightingale P, Abroug F, Pelosi P, Arabi Y, Moreno R, Jibaja M, D'Empaire G, Sandi F, Matamis D, Montanez AM, Anzueto A; VENTILA Group. Evolution of mechanical ventilation in response to clinical research. Am J Respir Crit Care Med. 2008 Jan 15;177(2):170-7. doi: 10.1164/rccm.200706-893OC. Epub 2007 Oct 25.

Reference Type: BACKGROUND

PMID: 17962636 (View on PubMed)

Nin N, Muriel A, Penuelas O, Brochard L, Lorente JA, Ferguson ND, Raymondos K, Rios F, Violi DA, Thille AW, Gonzalez M, Villagomez AJ, Hurtado J, Davies AR, Du B, Maggiore SM, Soto L, D'Empaire G, Matamis D, Abroug F, Moreno RP, Soares MA, Arabi Y, Sandi F, Jibaja M, Amin P, Koh Y, Kuiper MA, Bulow HH, Zeggwagh AA, Anzueto A, Sznajder JI, Esteban A; VENTILA Group. Severe hypercapnia and outcome of mechanically ventilated patients with moderate or severe acute respiratory distress syndrome. Intensive Care Med. 2017 Feb;43(2):200-208. doi: 10.1007/s00134-016-4611-1. Epub 2017 Jan 20.

Reference Type: DERIVED

PMID: 28108768 (View on PubMed)

Esteban A, Frutos-Vivar F, Muriel A, Ferguson ND, Penuelas O, Abraira V, Raymondos K, Rios F, Nin N, Apezteguia C, Violi DA, Thille AW, Brochard L, Gonzalez M, Villagomez AJ, Hurtado J, Davies AR, Du B, Maggiore SM, Pelosi P, Soto L, Tomicic V, D'Empaire G, Matamis D, Abroug F, Moreno RP, Soares MA, Arabi Y, Sandi F, Jibaja M, Amin P, Koh Y, Kuiper MA, Bulow HH, Zeggwagh AA, Anzueto A. Evolution of mortality over time in patients receiving mechanical ventilation. Am J Respir Crit Care Med. 2013 Jul 15;188(2):220-30. doi: 10.1164/rccm.201212-2169OC.

Reference Type: DERIVED

PMID: 23631814 (View on PubMed)

Other Identifiers

ISMV-2010

Identifier Type: -

Identifier Source: org_study_id