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Respiratory Mechanics Assessment During Assisted Mechanical Ventilation

NCT ID: NCT05203536

Last Updated: 2025-05-30

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

298 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-09-01

Study Completion Date

2023-06-03

Brief Summary

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To verify the association between respiratory system mechanical properties (ΔP, ΔPL,dyn, Pmus, Pplat and CRS and CL,dyn) assessed during assisted modes of ventilation (as average over the first three days since enrollment) and ICU mortality.

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Detailed Description

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Conditions

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Acute Hypoxemic Respiratory Failure

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* Acute Hypoxaemic Respiratory Failure (defined as respiratory failure requiring invasive mechanical ventilation with a PaO2/FiO2\< 300 mmHg) during the course of ICU stay (including ARDS).
* Invasive mechanical ventilation in one of these modes: Pressure A/C, PRVC, SIMV PC, PSV, NAVA, PAV+, BiPAP
* Presence of spontaneous breathing activity (ventilator triggering), since 6 hours and no longer than 48 hours
* Patient for full active management at this point.

Exclusion Criteria

* Age \<18 years old
* Pregnancy
* Active air leaks
* Moribund state
* High ICP
* Patient has passed a spontaneous breathing trial (if performed for clinical indication)
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University of Milano Bicocca

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Toronto General Hospital

Toronto, Toronto, Canada

Site Status

University Medical Centre Schleswig-Holstein

Kiel, Kiel, Germany

Site Status

University Hospital Galway

Galway, Galway, Ireland

Site Status

Ospedale Sant'Anna

Ferrara, Ferrara, Italy

Site Status

Policlinico di Milano Ospedale Maggiore

Milan, Milano, Italy

Site Status

ASST-Monza, Ospedale San Gerardo

Monza, Monza, Italy

Site Status

Vall d'Hebron University Hospital

Barcelona, Barcelona, Spain

Site Status

Hospital Clinic de Barcelona

Barcelona, Barcelona, Spain

Site Status

Countries

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Canada Germany Ireland Italy Spain

Other Identifiers

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3552

Identifier Type: -

Identifier Source: org_study_id

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