Placebo and Active Controlled Study to Assess Efficacy and Tolerability of Aspirin Plus Pseudoephedrine

NCT ID: NCT01062360

Last Updated: 2017-09-01

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

1016 participants

Study Classification

INTERVENTIONAL

Study Start Date

2005-12-23

Study Completion Date

2007-05-14

Brief Summary

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The purpose of this study is compare efficacy and tolerability of a fixed combination, containing 500 mg Acetylsalicylic acid and 30 mg Pseudoephedrine, in comparison to its single components in patients with sore throat and nasal congestion.

Detailed Description

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Conditions

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Common Cold Pharyngitis

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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Arm 1

Group Type EXPERIMENTAL

Acetylsalicylic Acid (Aspirin Complex, BAYE4465) + Pseudoephedrine

Intervention Type DRUG

Single oral dose of 1 to 2 Aspirin Complex sachets, each containing granules of 500 mg Acetylsalicylic Acid (ASA) and 30 mg Pseudoephedrine (PSE), to be taken orally after dissolving in a glass of water; to be repeated as needed every 6 hours for a period of not more than 3 days.

Arm 2

Group Type ACTIVE_COMPARATOR

Acetylsalicylic Acid (Aspirin, BAYE4465)

Intervention Type DRUG

Single oral dose of 1 to 2 sachets Acetylsalicylic Acid, each containing granules of 500 mg Acetylsalicylic Acid (ASA), to be taken orally after dissolving in a glass of water; to be repeated as needed every 6 hours for a period of not more than 3 days.

Arm 3

Group Type ACTIVE_COMPARATOR

Pseudoephedrine

Intervention Type DRUG

Single oral dose of 1 to 2 sachets Pseudoephedrine, each containing granules 30 mg Pseudoephedrine, to be taken orally after dissolving in a glass of water; to be repeated as needed every 6 hours for a period of not more than 3 days.

Arm 4

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type DRUG

Single oral dose of 1 to 2 sachets, each containing Placebo granules, to be taken orally after dissolving in a glass of water; to be repeated as needed every 6 hours for a period of not more than 3 days.

Interventions

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Acetylsalicylic Acid (Aspirin Complex, BAYE4465) + Pseudoephedrine

Single oral dose of 1 to 2 Aspirin Complex sachets, each containing granules of 500 mg Acetylsalicylic Acid (ASA) and 30 mg Pseudoephedrine (PSE), to be taken orally after dissolving in a glass of water; to be repeated as needed every 6 hours for a period of not more than 3 days.

Intervention Type DRUG

Acetylsalicylic Acid (Aspirin, BAYE4465)

Single oral dose of 1 to 2 sachets Acetylsalicylic Acid, each containing granules of 500 mg Acetylsalicylic Acid (ASA), to be taken orally after dissolving in a glass of water; to be repeated as needed every 6 hours for a period of not more than 3 days.

Intervention Type DRUG

Pseudoephedrine

Single oral dose of 1 to 2 sachets Pseudoephedrine, each containing granules 30 mg Pseudoephedrine, to be taken orally after dissolving in a glass of water; to be repeated as needed every 6 hours for a period of not more than 3 days.

Intervention Type DRUG

Placebo

Single oral dose of 1 to 2 sachets, each containing Placebo granules, to be taken orally after dissolving in a glass of water; to be repeated as needed every 6 hours for a period of not more than 3 days.

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

Inclusion Criteria:- Male and female subjects between 18 and 65 years of age.- Onset of cold symptoms within 96 hours (4 days) before study participation.- Current complaint of at least moderate sore throat at baseline- Current complaint of at least moderate NC at baseline- History of other symptoms associated with URTI during the last 4 days before study participation.- Other findings of URTI, confirmed on the physical examination.- Agreement to comply with the study requirements.

Exclusion Criteria

- Written informed consent prior to enrollment in the study Exclusion Criteria:- Pregnant or lactating females.- Uncontrolled chronic diseases.- History of hypersensitivity (allergic reaction) to ASA, any other nonsteroidal anti-inflammatory drugs (NSAIDs), or PSE.- Any disease which significantly compromises breathing or interferes with the subjects assessment of sore throat.- History of or active peptic ulcer.- Severe impaired hepatic function.- Severe impaired renal function.- Simultaneous intake of monoamine oxidase inhibitors.- Use of menthol containing tissues within 2 hours before first intake of study drug.- Intake of any menthol containing product within 4 hours before first intake of study drug.- Use of any local or systemic short acting cough and cold preparations within 6 hours before first intake of study drug.- Use of any local or systemic long acting cough and cold preparations within 12 hours before first intake of study drug.- Intake of any analgesic within 12 hours before first intake of study drug.- Intake or requirement of any prescription medication for the treatment of the current acute respiratory tract infection.- Current or previous intake of anticoagulants, corticoids, NSAIDs, methotrexate, or lithium.- Participation in another clinical trial within the last 30 days.
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Bayer

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Bayer Study Director

Role: STUDY_DIRECTOR

Bayer

Locations

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New York, New York, United States

Site Status

New York, New York, United States

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Alassio, , Italy

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Albenga, , Italy

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Arenzano, , Italy

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Civitella Marittima, , Italy

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Follonica, , Italy

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Genova, , Italy

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Genova, , Italy

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Genova, , Italy

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Genova, , Italy

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Genova, , Italy

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Genova, , Italy

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Genova, , Italy

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Genova, , Italy

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Genova, , Italy

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Genova, , Italy

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Grosseto, , Italy

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Grossetto, , Italy

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Isola del Cantone, , Italy

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Loano, , Italy

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Masone, , Italy

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Orbetello, , Italy

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Pegli, , Italy

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Quiliano, , Italy

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Rivarolo, , Italy

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Ronco Scrivia, , Italy

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Sampierdarena, , Italy

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Scansano, , Italy

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Serra Riccò, , Italy

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Varazze, , Italy

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Ciechocin, , Poland

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Dębowa Góra, , Poland

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Katowice, , Poland

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Katowice, , Poland

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Katowice, , Poland

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Krakow, , Poland

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Lodz, , Poland

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Piaseczno, , Poland

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Skierniewice, , Poland

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Szczecin, , Poland

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Szczecin, , Poland

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Torun, , Poland

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Warsaw, , Poland

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Warsaw, , Poland

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Warsaw, , Poland

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Warsaw, , Poland

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Warsaw, , Poland

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Warsaw, , Poland

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Zabrze, , Poland

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Bratislava, , Slovakia

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Bratislava, , Slovakia

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Bratislava, , Slovakia

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Bratislava, , Slovakia

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Bratislava, , Slovakia

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Bratislava, , Slovakia

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Bratislava, , Slovakia

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Pezinok, , Slovakia

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Stupava, , Slovakia

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Countries

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United States Italy Poland Slovakia

Related Links

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http://www.clinicaltrialsregister.eu/

Click here to find information about studies related to Bayer Healthcare products conducted in Europe

Other Identifiers

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2005-001720-36

Identifier Type: EUDRACT_NUMBER

Identifier Source: secondary_id

11764

Identifier Type: -

Identifier Source: org_study_id

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