Non-influenza Etiologies of Acute Respiratory Illness in Southeast Asia

NCT ID: NCT01048073

Last Updated: 2011-05-27

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

1200 participants

Study Classification

OBSERVATIONAL

Study Start Date

2010-05-31

Study Completion Date

2010-12-31

Brief Summary

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Acute respiratory infection (ARI) constitutes a leading cause of morbidity, hospitalization and mortality worldwide. The most common etiologic agents of ARI's, especially in children, are viruses.

The study objective is to determine the viral and bacterial etiologies of ARIs in patients with lower respiratory tract infection in South East Asia.

This is a laboratory based surveillance study, in which the archival specimens from hospitalized patients will be tested for respiratory pathogens other than influenza viruses Standard descriptive statistics will be used to present the findings

Detailed Description

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This study will test 1400 specimens from 1200 patients at the following laboratories:

* National Hospital of Pediatrics, Hanoi
* National Institute of Infectious and Tropical Diseases, Hanoi
* Siriraj Hospital, Bangkok
* National Institute of Health Research and Development, Jakarta
* Hospital for Tropical Diseases, HCMC
* Children Hospital #1, Ho Chi Minh City
* Children Hospital #2, Ho Chi Minh City
* Queen Sirikit National Institute of Child Health

Conditions

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Lower Respiratory Tract Infection

Study Design

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Study Time Perspective

CROSS_SECTIONAL

Eligibility Criteria

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Inclusion Criteria

* Adequately stored respiratory specimens obtained from hospitalized patients suspected of lower respiratory tract infection and were tested for influenza.

Exclusion Criteria

* Specimens stored at insufficient temperature
* Specimen volume is insufficient
* No demographic data available
* Specimen unsuitable for testing for other technical reasons
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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National Institute of Allergy and Infectious Diseases (NIAID)

NIH

Sponsor Role collaborator

University of Oxford

OTHER

Sponsor Role collaborator

South East Asia Infectious Disease Clinical Research Network

NETWORK

Sponsor Role lead

Responsible Party

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Siriraj Hospital Bangkok, Thailand

Principal Investigators

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Pilaipan Pilaipan Puthavathana, MD, Ph.D

Role: PRINCIPAL_INVESTIGATOR

Siriraj Hospital, Bangkok, Thailand

Locations

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National Institute of Health Research and Development

Jakarta, , Indonesia

Site Status

Queen Sirikit National Institute of Child Health

Bangkok, , Thailand

Site Status

Siriraj Hospital

Bangkok, , Thailand

Site Status

National Hospital of Pediatrics

Hanoi, , Vietnam

Site Status

National Hospital of Tropical Diseases

Hanoi, , Vietnam

Site Status

Oxford University Clinical Research Unit

Hanoi, , Vietnam

Site Status

Children's Hospital No 1

Ho Chi Minh City, , Vietnam

Site Status

Children's Hospital No 2

Ho Chi Minh City, , Vietnam

Site Status

Hospital for Tropical Diseases

Ho Chi Minh City, , Vietnam

Site Status

Countries

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Indonesia Thailand Vietnam

References

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I P M, Nelson EA, Cheuk ES, Leung E, Sung R, Chan PK. Pediatric hospitalization of acute respiratory tract infections with Human Bocavirus in Hong Kong. J Clin Virol. 2008 May;42(1):72-4. doi: 10.1016/j.jcv.2007.12.016. Epub 2008 Mar 4.

Reference Type BACKGROUND
PMID: 18296108 (View on PubMed)

Tsang KW, File TM Jr. Respiratory infections unique to Asia. Respirology. 2008 Nov;13(7):937-49. doi: 10.1111/j.1440-1843.2008.01409.x.

Reference Type BACKGROUND
PMID: 18945321 (View on PubMed)

Yuan XH, Jin Y, Xie ZP, Gao HC, Xu ZQ, Zheng LS, Zhang RF, Song JR, Hou YD, Duan ZJ. Prevalence of human KI and WU polyomaviruses in children with acute respiratory tract infection in China. J Clin Microbiol. 2008 Oct;46(10):3522-5. doi: 10.1128/JCM.01301-08. Epub 2008 Jul 30.

Reference Type BACKGROUND
PMID: 18667596 (View on PubMed)

Drews SJ, Blair J, Lombos E, DeLima C, Burton L, Mazzulli T, Low DE. Use of the Seeplex RV Detection kit for surveillance of respiratory viral outbreaks in Toronto, Ontario, Canada. Ann Clin Lab Sci. 2008 Autumn;38(4):376-9.

Reference Type BACKGROUND
PMID: 18988931 (View on PubMed)

Roh KH, Kim J, Nam MH, Yoon S, Lee CK, Lee K, Yoo Y, Kim MJ, Cho Y. Comparison of the Seeplex reverse transcription PCR assay with the R-mix viral culture and immunofluorescence techniques for detection of eight respiratory viruses. Ann Clin Lab Sci. 2008 Winter;38(1):41-6.

Reference Type BACKGROUND
PMID: 18316781 (View on PubMed)

Yoo SJ, Kuak EY, Shin BM. Detection of 12 respiratory viruses with two-set multiplex reverse transcriptase-PCR assay using a dual priming oligonucleotide system. Korean J Lab Med. 2007 Dec;27(6):420-7. doi: 10.3343/kjlm.2007.27.6.420.

Reference Type BACKGROUND
PMID: 18160832 (View on PubMed)

Other Identifiers

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SEA 019

Identifier Type: -

Identifier Source: org_study_id

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