Recurrent Pneumonia in Children

NCT ID: NCT06583317

Last Updated: 2024-09-04

Basic Information

• Recruitment Status: NOT_YET_RECRUITING
• Total Enrollment: 53 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2025-01-01
• Study Completion Date: 2026-01-31

Brief Summary

This study aimed to analyses the clinical characteristics, risk factors and underlying causes as predictors of recurrent pneumonia in children attending AUCH

Detailed Description

Pneumonia is defined as inflammation of lung parenchyma due to various pathogenic organisms including bacteria, viruses, fungi and parasites. The key symptom to suspect childhood pneumonia is tachypnea. The World Health Organization (WHO) has defined tachypnea as respiratory rate >60 breaths/min in infants less than 2 months, >50 in infants 2 -12 months and >40 in children 1 to 5 years and >20 in children >5 years of age [1]. WHO has categorized pneumonia in children under-five years of age into two categories, pneumonia and severe pneumonia. Tachypnea with or without chest retraction is categorized as pneumonia while tachypnea with any danger signs (unable to feed or drink, hypothermia, unconsciousness, convulsion, signs of hypoxia including cyanosis, grunting, groaning, head nodding) as severe pneumonia [1].

Pneumonia is a common and described as the overlooked killer of children[2] as killing 1.1-1.4 million children every year. It accounts for 17%-19% of all deaths amongst children under 5 years of age; the majority of them are in developing countries [3,4] .In Egypt, children under 5 years approximate 13.4% of the total population[4] and pneumonia constitutes 19% of under-five mortality[5].

Recurrent pneumonia (RP) is defined as at least two episodes of pneumonia in one year or three episodes ever, with intercritical radiographic clearing of densities [6]. Incidence data indicate that RP occurs in 7.7%-9% of all children with CAP [7,8,9,10,11,12]. As a result, RP represents a frequent presenting manifestation in the general pediatric practice and is a very common reason for referral to pediatric chest physicians [7]. Factors linked to these infections could be recurrent aspirations, congenital structural anomalies of pulmonary and cardiovascular systems, defects in the clearance of airway secretions and immunodeficiency [13]

Conditions

Pneumonia; Lower Respiratory Tract Infection; Chest Infection

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Eligibility Criteria

Inclusion Criteria

• • All children more than 1 month and less than 18 years of age

• All cases presented by picture of recurrent pneumonia in the form of as at least two episodes of pneumonia in one year or three episodes ever, with radiographic clearing of densities in between.

Exclusion Criteria

• • All children less than 1 month and more than 18 years

• Evidence of malignancies
• Evidence of congenital immune deficiency
• Cases refusing to participate in research.
• Cases missed for follow up.

• Minimum Eligible Age: 30 Days
• Maximum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Assiut University

OTHER

Sponsor Role: lead

Responsible Party

Dalia Abdelnaser Marouf Ahmed

71515,Assiut

Responsibility Role: PRINCIPAL_INVESTIGATOR

Central Contacts

Dalia Abdelnaser Marouf, Bachelor of Medicine

Role: CONTACT

daliamarof291@gmail.com

01093573433

Maher Mokhtar Ahmed, Professor of Pediatrics

Role: CONTACT

Maher61ahmed@aun.edu.eg

01066006605

References

Nair H, Simoes EA, Rudan I, Gessner BD, Azziz-Baumgartner E, Zhang JSF, Feikin DR, Mackenzie GA, Moiisi JC, Roca A, Baggett HC, Zaman SM, Singleton RJ, Lucero MG, Chandran A, Gentile A, Cohen C, Krishnan A, Bhutta ZA, Arguedas A, Clara AW, Andrade AL, Ope M, Ruvinsky RO, Hortal M, McCracken JP, Madhi SA, Bruce N, Qazi SA, Morris SS, El Arifeen S, Weber MW, Scott JAG, Brooks WA, Breiman RF, Campbell H; Severe Acute Lower Respiratory Infections Working Group. Global and regional burden of hospital admissions for severe acute lower respiratory infections in young children in 2010: a systematic analysis. Lancet. 2013 Apr 20;381(9875):1380-1390. doi: 10.1016/S0140-6736(12)61901-1. Epub 2013 Jan 29.

Reference Type: BACKGROUND

PMID: 23369797 (View on PubMed)

Bhutta ZA, Das JK, Walker N, Rizvi A, Campbell H, Rudan I, Black RE; Lancet Diarrhoea and Pneumonia Interventions Study Group. Interventions to address deaths from childhood pneumonia and diarrhoea equitably: what works and at what cost? Lancet. 2013 Apr 20;381(9875):1417-1429. doi: 10.1016/S0140-6736(13)60648-0. Epub 2013 Apr 12.

Reference Type: BACKGROUND

PMID: 23582723 (View on PubMed)

Other Identifiers

pnemonia

Identifier Type: -

Identifier Source: org_study_id