Efficacy and Safety in Patients With Type 2 Diabetes Mellitus and Cardiovascular Disease

NCT ID: NCT01042977

Last Updated: 2014-02-17

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

964 participants

Study Classification

INTERVENTIONAL

Study Start Date

2010-03-31

Study Completion Date

2012-12-31

Brief Summary

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This study is carried out to assess whether dapagliflozin improves glycemic control, decreases fasting plasma glucose levels, body weight and blood pressure when added to patient's existing medications and how it compares with their usual treatment without added dapagliflozin. Safety data will be collected and analysed to confirm that treatment with dapagliflozin is safe and well tolerated in patients who have diabetes and cardiovascular disease

Detailed Description

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Conditions

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Type 2 Diabetes Mellitus Cardiovascular Disease Inadequate Glycaemic Control

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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1

dapagliflozin 10 mg tablet

Group Type EXPERIMENTAL

Dapagliflozin

Intervention Type DRUG

10 mg tablet, oral, once daily, 24- week treatment and 80-week extension period

2

matching placebo tablet

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type DRUG

matching placebo tablet, oral, once daily, 24- week treatment and 80-week extension period

Interventions

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Dapagliflozin

10 mg tablet, oral, once daily, 24- week treatment and 80-week extension period

Intervention Type DRUG

Placebo

matching placebo tablet, oral, once daily, 24- week treatment and 80-week extension period

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Type 2 diabetes mellitus.
* Cardiovascular disease
* Uninterrupted anti-diabetic treatment for at least 8 weeks before enrolment

Exclusion Criteria

* Patients with type 1 diabetes or diabetes insipidus
* Patients with 3 or more oral anti-hyperglycaemic drugs with or without insulin and/or poorly controlled diabetes
* Any clinically significant illness, which would compromise the patient's safety and their participation in the study
Minimum Eligible Age

45 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Bristol-Myers Squibb

INDUSTRY

Sponsor Role collaborator

AstraZeneca

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Dr. Lawrence A Leiter, MD

Role: PRINCIPAL_INVESTIGATOR

Division of Endocrinology & Metabolism, St Michael's Hospital

Locations

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Birmingham, Alabama, United States

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Scottsdale, Arizona, United States

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Anaheim, California, United States

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Bell Gardens, California, United States

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Chino, California, United States

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Chula Vista, California, United States

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Huntington Beach, California, United States

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Los Angeles, California, United States

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Mission Hills, California, United States

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Redondo Beach, California, United States

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Riverside, California, United States

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Sacramento, California, United States

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San Diego, California, United States

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Torrance, California, United States

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Aventura, Florida, United States

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Boca Raton, Florida, United States

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Bradenton, Florida, United States

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Brooksville, Florida, United States

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Clearwater, Florida, United States

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Dania Beach, Florida, United States

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Delray Beach, Florida, United States

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New Smyrna Beach, Florida, United States

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Orlando, Florida, United States

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Springfield, Illinois, United States

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Avon, Indiana, United States

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Franklin, Indiana, United States

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Greenfield, Indiana, United States

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Muncie, Indiana, United States

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Waterloo, Iowa, United States

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Topeka, Kansas, United States

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Paducah, Kentucky, United States

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Alexandria, Louisiana, United States

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Rockville, Maryland, United States

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Kalamazoo, Michigan, United States

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Livonia, Michigan, United States

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Billings, Montana, United States

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Berlin, New Jersey, United States

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Brick, New Jersey, United States

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Asheboro, North Carolina, United States

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Fargo, North Dakota, United States

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Cincinnati, Ohio, United States

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Oklahoma City, Oklahoma, United States

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Altoona, Pennsylvania, United States

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Erie, Pennsylvania, United States

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Holland, Pennsylvania, United States

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Lancaster, Pennsylvania, United States

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Media, Pennsylvania, United States

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Philadelphia, Pennsylvania, United States

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Austin, Texas, United States

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Corpus Christi, Texas, United States

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Dallas, Texas, United States

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Irving, Texas, United States

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Richardson, Texas, United States

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San Antonio, Texas, United States

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Sugarland, Texas, United States

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Alexandria, Virginia, United States

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Manassas, Virginia, United States

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Buenos Aires, Buenos Aires F.D., Argentina

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Córdoba, Córdoba Province, Argentina

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Salta, Salta Province, Argentina

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Rosario, Santa Fe Province, Argentina

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Santa Fe, Santa Fe Province, Argentina

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Blacktown, New South Wales, Australia

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Broadmeadow, New South Wales, Australia

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Hornsby, New South Wales, Australia

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Wollongong, New South Wales, Australia

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Carina Heights, Queensland, Australia

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Kippa-Ring, Queensland, Australia

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Adelaide, South Australia, Australia

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Bedford Park, South Australia, Australia

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Keswick, South Australia, Australia

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Box Hill, Victoria, Australia

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Heidelberg, Victoria, Australia

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Herston, , Australia

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Vienna, , Austria

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Blagoevgrad, , Bulgaria

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Pernik, , Bulgaria

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Pleven, , Bulgaria

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Rousse, , Bulgaria

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Sevlievo, , Bulgaria

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Sofia, , Bulgaria

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Stara Zagora, , Bulgaria

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Varna, , Bulgaria

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Calgary, Alberta, Canada

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Edmonton, Alberta, Canada

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Moncton, New Brunswick, Canada

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Bay Roberts, Newfoundland and Labrador, Canada

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Halifax, Nova Scotia, Canada

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Etobicoke, Ontario, Canada

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Ottawa, Ontario, Canada

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Scarborough Village, Ontario, Canada

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Thornhill, Ontario, Canada

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Toronto, Ontario, Canada

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Mirabel, Quebec, Canada

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Québec, Quebec, Canada

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Santiago, Santiago Metropolitan, Chile

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Damme, , Germany

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Dortmund, , Germany

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Homburg, , Germany

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Münster, , Germany

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Wangen, , Germany

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Ajka, , Hungary

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Balatonfüred, , Hungary

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Budapest, , Hungary

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Esztergom, , Hungary

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Győr, , Hungary

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Komárom, , Hungary

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Mosonmagyaróvár, , Hungary

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Tát, , Hungary

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Veszprém, , Hungary

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Bialystok, , Poland

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Chrzanów, , Poland

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Gdansk, , Poland

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Grodzisk Mazowiecki, , Poland

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Iława, , Poland

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Kielce, , Poland

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Krakow, , Poland

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Lodz, , Poland

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Lublin, , Poland

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Mrągowo, , Poland

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Nowy Sącz, , Poland

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Poznan, , Poland

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Płock, , Poland

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Ruda Śląska, , Poland

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Skierniewice, , Poland

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Sopot, , Poland

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Tarnów, , Poland

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Torun, , Poland

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Warsaw, , Poland

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Wroclaw, , Poland

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Zabrze, , Poland

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Zgierz, , Poland

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Zielona Góra, , Poland

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Łęczna, , Poland

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Łęczyca, , Poland

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Countries

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United States Argentina Australia Austria Bulgaria Canada Chile Germany Hungary Poland

References

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Natale P, Tunnicliffe DJ, Toyama T, Palmer SC, Saglimbene VM, Ruospo M, Gargano L, Stallone G, Gesualdo L, Strippoli GF. Sodium-glucose co-transporter protein 2 (SGLT2) inhibitors for people with chronic kidney disease and diabetes. Cochrane Database Syst Rev. 2024 May 21;5(5):CD015588. doi: 10.1002/14651858.CD015588.pub2.

Reference Type DERIVED
PMID: 38770818 (View on PubMed)

Other Identifiers

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D1690C00019

Identifier Type: -

Identifier Source: org_study_id

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