Intradialytic Progressive Resistance Training for Maintenance Haemodialysis Patients
NCT ID: NCT01007838
Last Updated: 2012-01-05
Study Results
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View full resultsBasic Information
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COMPLETED
NA
32 participants
INTERVENTIONAL
2009-01-31
2011-10-31
Brief Summary
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It is hypothesised, based on previous literature involving similar resistance training protocols in other catabolic conditions, that the resistance training will result in a significant increase in muscle quantity as well a physical function.
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Detailed Description
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In other catabolic conditions, such as cancer or rheumatoid arthritis, exercise is an established treatment to reverse muscle wasting. It is uncertain whether exercise has this effect in the chronic kidney disease population due to an altered hormone system that may prevent the anabolic effects of exercise from occurring. However, progressive resistance training, which is exercise that is most effective at eliciting an anabolic response has not been effectively carried out with haemodialysis patients.
Therefore, this study aims to investigate whether or not a twelve week intradialytic progressive resistance training programme will have an effect on muscle quantity, physical function and quality of life in patients receiving maintenance haemodialysis.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
SINGLE
Study Groups
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Chronic kidney disease progressive resistance training group
Progressive resistance training programme using a dialysis specific fitness machine: 80 % of predicted one repetition max, weight lifted will be increased when three sets of ten repetitions can be completed without failure.
Progressive resistance training programme
Progressive resistance training programme using a dialysis specific fitness machine: 80 % of predicted one repetition max, weight lifted will be increased when three sets of ten repetitions can be completed without failure.
Chronic kidney disease sham exercise group
Lower body stretching exercise using the easiest rehabilitation elastic Theraband
Sham exercise
Lower body stretching exercise using the easiest rehabilitation elastic Theraband
Healthy controls progressive resistance training group
Progressive resistance training programme using a dialysis specific fitness machine: 80 % of predicted one repetition max, weight lifted will be increased when three sets of ten repetitions can be completed without failure.
Progressive resistance training
Progressive resistance training programme using a dialysis specific fitness machine: 80 % of predicted one repetition max, weight lifted will be increased when three sets of ten repetitions can be completed without failure.
Healthy controls sham exercise group
Lower body stretching exercise using the easiest rehabilitation elastic Theraband
Sham exercise
Lower body stretching exercise using the easiest rehabilitation elastic Theraband
Interventions
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Progressive resistance training programme
Progressive resistance training programme using a dialysis specific fitness machine: 80 % of predicted one repetition max, weight lifted will be increased when three sets of ten repetitions can be completed without failure.
Sham exercise
Lower body stretching exercise using the easiest rehabilitation elastic Theraband
Progressive resistance training
Progressive resistance training programme using a dialysis specific fitness machine: 80 % of predicted one repetition max, weight lifted will be increased when three sets of ten repetitions can be completed without failure.
Sham exercise
Lower body stretching exercise using the easiest rehabilitation elastic Theraband
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* Are under the age of 18years;
* Have medical contradictions to participate in the exercise programs;
* Any uncontrolled medical condition which does not allow participation in exercise;
* Have known neuro-muscular disorders;
* Have any other uncontrolled medical condition, including pregnancy;
* Are not independently ambulant for 50 m;
* Have received anabolic intervention, or had catabolic conditions within the last 3 months;
* Have a cardiac pacemaker or other unsuitable implanted device for magnetic resonance;
* Are vulnerable to heat stress;
* Or are unable to give consent.
18 Years
ALL
No
Sponsors
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Betsi Cadwaladr University Health Board
OTHER_GOV
Bangor University
OTHER
Responsible Party
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Principal Investigators
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Jamie H MacDonald, PhD
Role: PRINCIPAL_INVESTIGATOR
Bangor University
Locations
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Renal unit, Ysbyty Gwynedd, North West Wales NHS Trust
Bangor, Gwynedd, United Kingdom
Countries
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Other Identifiers
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R& D Ref no: MACDONALD 07/53
Identifier Type: -
Identifier Source: org_study_id
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