Multicenter Hologic Tomosynthesis Study

NCT ID: NCT00971087

Last Updated: 2025-02-26

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

3521 participants

Study Classification

INTERVENTIONAL

Study Start Date

2009-09-30

Study Completion Date

2012-04-30

Brief Summary

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The purpose of this image acquisition study is to compare, in a Reader Study, the performance of Tomosynthesis (3D) to (2D FFDM) conventional images in an enriched retrospective reader study. Synthetic 2D images, generated from the tomosynthesis image, will be available to the readers to provide an over view of the anatomy similar to a scout view in CT imaging and to determine whether the 3-D images with the synthesized 2D overview are non-inferior to the 2-D images alone as determined by receiver operating characteristic (ROC) area under the curve.

Detailed Description

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Conditions

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Breast Cancer

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

SCREENING

Blinding Strategy

NONE

Study Groups

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Subjects undergoing breast cancer screening

The study population included both women undergoing routing annual mammography imaging and women undergoing a previously scheduled breast biopsy

Group Type OTHER

Hologic Selenia Dimensions Digital Breast Tomosynthesis System

Intervention Type DEVICE

Subjects are exposed to the same number of investigational images collected on the investigational device (Selenia Dimensions Full Field Digital Mammography System). Subject enrollment occurs at the time subjects are being imaged for their standard of care mammographic work up (either screening mammogram or scheduled biopsy). All subjects undergoing a biopsy procedure will be imaged on the investigational device prior to their procedure.

Interventions

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Hologic Selenia Dimensions Digital Breast Tomosynthesis System

Subjects are exposed to the same number of investigational images collected on the investigational device (Selenia Dimensions Full Field Digital Mammography System). Subject enrollment occurs at the time subjects are being imaged for their standard of care mammographic work up (either screening mammogram or scheduled biopsy). All subjects undergoing a biopsy procedure will be imaged on the investigational device prior to their procedure.

Intervention Type DEVICE

Other Intervention Names

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Tomosynthesis Tomo Breast tomosynthesis 3D Breast imaging Selenia Dimensions 2D plus 3D breast imaging

Eligibility Criteria

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Inclusion Criteria

* Female
* Any ethnic origin
* No contraindication of routine bilateral mammography

Exclusion Criteria

* Any contraindications to mammographic screening, including but not limited to:
* Significant existing breast trauma
* Pregnancy
* Lactating
* Previous surgical biopsy
* Previous breast cancer
* Placement of an internal breast marker
* Breast implants
* Unable to understand and execute written informed consent
* Breasts are too large to be imaged on the 24 cm by 29 cm detector with a single exposure
Minimum Eligible Age

18 Years

Maximum Eligible Age

110 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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Hologic, Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Scottsdale Medical Imaging Ltd. (SMIL)

Scottsdale, Arizona, United States

Site Status

Hoag Memorial Hospital

Newport Beach, California, United States

Site Status

UC Davis

Sacramento, California, United States

Site Status

Invision/Sally Jobe

Greenwood Village, Colorado, United States

Site Status

Boca Raton Community Hospital

Boca Raton, Florida, United States

Site Status

Memorial Florida

Hollywood, Florida, United States

Site Status

Luthern General - Advocate Health Care

Chicago, Illinois, United States

Site Status

Massachusetts General Hospital

Boston, Massachusetts, United States

Site Status

Spectrum Health

Grand Rapids, Michigan, United States

Site Status

Mayo Clinic

Rochester, Minnesota, United States

Site Status

Barnes Jewish

St Louis, Missouri, United States

Site Status

Elizabeth Wende Breast Clinic

Rochester, New York, United States

Site Status

University of Cincinnati

Cincinnati, Ohio, United States

Site Status

University Hospitals Case Medical Center

Cleveland, Ohio, United States

Site Status

Albert Einstein Medical Center

Philadelphia, Pennsylvania, United States

Site Status

Magee Women's Hospital

Pittsburgh, Pennsylvania, United States

Site Status

York - Women's Imaging at Apple Hill

York, Pennsylvania, United States

Site Status

UTSW Center for Breast Care

Dallas, Texas, United States

Site Status

Memorial Hermann/ Memorial City

Houston, Texas, United States

Site Status

Intermountain Medical Imaging

Murray, Utah, United States

Site Status

Fletcher Allen Health Care

Burlington, Vermont, United States

Site Status

University of Virginia

Charlottesville, Virginia, United States

Site Status

Countries

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United States

Other Identifiers

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09-03

Identifier Type: -

Identifier Source: org_study_id

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