Cassia Cinnamon for Glucose Uptake in Young Women

NCT ID: NCT00951639

Last Updated: 2022-03-17

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

10 participants

Study Classification

INTERVENTIONAL

Study Start Date

2008-02-29

Study Completion Date

2009-05-31

Brief Summary

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The purpose of this study was to compare the acute effects of 5g of Cassia cinnamon, 50 minutes of endurance exercise performed at 70% of the heart rate reserve (correlated to VO2max), and 5g of cellulose placebo on blood glucose, serum insulin and insulin sensitivity following an oral glucose tolerance test 3 hours after administration of each intervention.

Detailed Description

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Conditions

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Insulin Resistance Impaired Glucose Tolerance Prediabetes

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

SUPPORTIVE_CARE

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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5g Cassia cinnamon

Experimental treatment group

Group Type EXPERIMENTAL

Cassia cinnamon

Intervention Type DIETARY_SUPPLEMENT

5g encapsulated ground bark administered once in experimental session

50 minutes endurnace exercise

Endurance exercise treatment known to influence blood glucose

Group Type ACTIVE_COMPARATOR

50 minutes exercise

Intervention Type PROCEDURE

50 minutes treadmill endurance exercise at 70% of the heart rate reserve (correlated to VO2max)

5g Cellulose

Placebo equivalent in weight and appearance to experimental treatment

Group Type PLACEBO_COMPARATOR

Cellulose Powder

Intervention Type DIETARY_SUPPLEMENT

5g encapsulated powder administered during placebo experimental session

Interventions

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Cassia cinnamon

5g encapsulated ground bark administered once in experimental session

Intervention Type DIETARY_SUPPLEMENT

50 minutes exercise

50 minutes treadmill endurance exercise at 70% of the heart rate reserve (correlated to VO2max)

Intervention Type PROCEDURE

Cellulose Powder

5g encapsulated powder administered during placebo experimental session

Intervention Type DIETARY_SUPPLEMENT

Other Intervention Names

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Brand: Nature's Bounty

Eligibility Criteria

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Inclusion Criteria

* Sedentary
* BMI: 27-45
* DXA body fat % greater than 30%
* 18-30 years of age
* Healthy
* From the Baylor University campus and surrounding community
* Regular sleep habits

Exclusion Criteria

* Not regular users of any species of cinnamon
* Not diagnosed with any metabolic disorder or chronic medical condition
* Not taking prescription medications for 2 months before the study
* Not taking ergogenic aids for 2 months before the study
* Not taking oral contraceptives for 2 months before the study
* No IUD placed for 2 months before the study
Minimum Eligible Age

18 Years

Maximum Eligible Age

30 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

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Baylor University

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Darryn S Willoughby, Ph.D.

Role: STUDY_CHAIR

Baylor University

Jean L Gutierrez, Ph.D.

Role: PRINCIPAL_INVESTIGATOR

Baylor University

Locations

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Baylor University Department of Health, Human Performance, and Recreation

Waco, Texas, United States

Site Status

Countries

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United States

References

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Hlebowicz J, Darwiche G, Bjorgell O, Almer LO. Effect of cinnamon on postprandial blood glucose, gastric emptying, and satiety in healthy subjects. Am J Clin Nutr. 2007 Jun;85(6):1552-6. doi: 10.1093/ajcn/85.6.1552.

Reference Type BACKGROUND
PMID: 17556692 (View on PubMed)

Hlebowicz J, Hlebowicz A, Lindstedt S, Bjorgell O, Hoglund P, Holst JJ, Darwiche G, Almer LO. Effects of 1 and 3 g cinnamon on gastric emptying, satiety, and postprandial blood glucose, insulin, glucose-dependent insulinotropic polypeptide, glucagon-like peptide 1, and ghrelin concentrations in healthy subjects. Am J Clin Nutr. 2009 Mar;89(3):815-21. doi: 10.3945/ajcn.2008.26807. Epub 2009 Jan 21.

Reference Type BACKGROUND
PMID: 19158209 (View on PubMed)

Solomon TP, Blannin AK. Changes in glucose tolerance and insulin sensitivity following 2 weeks of daily cinnamon ingestion in healthy humans. Eur J Appl Physiol. 2009 Apr;105(6):969-76. doi: 10.1007/s00421-009-0986-9. Epub 2009 Jan 22.

Reference Type BACKGROUND
PMID: 19159947 (View on PubMed)

Solomon TP, Blannin AK. Effects of short-term cinnamon ingestion on in vivo glucose tolerance. Diabetes Obes Metab. 2007 Nov;9(6):895-901. doi: 10.1111/j.1463-1326.2006.00694.x.

Reference Type BACKGROUND
PMID: 17924872 (View on PubMed)

Other Identifiers

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BaylorU_Cassia_Women

Identifier Type: -

Identifier Source: org_study_id

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