Pilot Assessment of Continuous Glucose Monitor for Post-meal Glucose Responses to Herbs and Spices.

NCT ID: NCT07254624

Last Updated: 2025-12-17

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Clinical Phase

NA

Total Enrollment

10 participants

Study Classification

INTERVENTIONAL

Study Start Date

2026-01-31

Study Completion Date

2027-11-30

Brief Summary

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The purpose of this study is to determine whether continuous glucose monitoring is sensitive to quantifying the glucose response related to consumption of a starchy vegetable (potato) in combination with or separate from consumption of herbs and spices at the same meal.

Detailed Description

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This is a pilot study which will enroll a maximum of 10 participants. There will be 3 different food entree preparations that participants will consume (1 entree per day within the 10 day period). The order in which participants eat the different entrees will be randomized. The 3 different food entree preparations are as follows: 1) prepared potato entree with no herbs and spices, 2) prepared potato entree paired with herbs and spices, 3) prepared potato entree with herbs and spices consumed at a subsequent meal.

Following enrollment, participants will be randomized to the order of entree preparation types and provided all of the entrees with the instructions for food preparation and order of consumption noted when they arrive at the scheduled study visit. The entrees will be standardized for caloric content, composition, and preparation method. Post-consumption glucose responses will be recorded by continuous glucose monitors, which will be provided to participants at the first study visit.

Conditions

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Post-prandial Glucose Response

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Participants will serve as their own controls in this study. They will be randomized to the order they receive the prepared entrees. Post-prandial glucose responses will be compared across the three entree types.
Primary Study Purpose

OTHER

Blinding Strategy

SINGLE

Outcome Assessors

Study Groups

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Potato entree with no herbs or spices

consumption of a standardized potato entree, matched for macronutrient, calorie and preparation method across arms

Group Type SHAM_COMPARATOR

Potato entree

Intervention Type OTHER

A potato entree with a fixed macronutrient and calorie content, and standardized preparation method to evoke a post-prandial glucose response

Potato entree with herbs or spices

consumption of a standardized potato entree including a mix of five herbs and spices at a fixed amount, matched for macronutrient, calorie and preparation method across arms

Group Type EXPERIMENTAL

Mix of five herbs and spices

Intervention Type OTHER

Herb and spice blend of dried oregano, basil, rosemary, garlic powder and onion powder

Potato entree

Intervention Type OTHER

A potato entree with a fixed macronutrient and calorie content, and standardized preparation method to evoke a post-prandial glucose response

Potato entree with no herbs or spices, with herbs and spices mix at a subsequent meal

consumption of a standardized potato entree, matched for macronutrient, calorie and preparation method across arms - with a provision including a mix of five herbs and spices at a fixed amount to be consumed at a subsequent meal within the same day (\>2 hours following the potato entree consumption)

Group Type SHAM_COMPARATOR

Mix of five herbs and spices

Intervention Type OTHER

Herb and spice blend of dried oregano, basil, rosemary, garlic powder and onion powder

Potato entree

Intervention Type OTHER

A potato entree with a fixed macronutrient and calorie content, and standardized preparation method to evoke a post-prandial glucose response

Interventions

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Mix of five herbs and spices

Herb and spice blend of dried oregano, basil, rosemary, garlic powder and onion powder

Intervention Type OTHER

Potato entree

A potato entree with a fixed macronutrient and calorie content, and standardized preparation method to evoke a post-prandial glucose response

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* body mass index (BMI): 20-35
* no dietary restriction or food allergies to study items
* weight stable
* access to a smart phone
* willingness to wear a continuous glucose monitor for the duration of the study (at minimum 10 days)

Exclusion Criteria

* pregnancy or anticipating pregnancy or lactation
* food allergy to study items
* diagnosed diabetes (type 1 or 2) or taking diabetes medications
* history of bariatric surgery
* consumed \>1 serving of potatoes daily before enrollment
* 5% weight loss or gain within the past 6 months
* medical conditions or medication that would prevent the ability to comply with the treatment assignment and/or affect blood glucose or energy balance
* condition which would prevent the ability to wear a continuous glucose monitor on the upper arm for the study duration
Minimum Eligible Age

18 Years

Maximum Eligible Age

50 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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McCormick Science Institute

INDUSTRY

Sponsor Role collaborator

University of Alabama at Birmingham

OTHER

Sponsor Role lead

Responsible Party

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Daniel L. Smith, Jr.

Associate Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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University of Alabama at Birmingham

Birmingham, Alabama, United States

Site Status

Countries

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United States

Central Contacts

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Daniel L Smith Jr, PhD

Role: CONTACT

205-934-4086

Other Identifiers

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McCormick Science Institute

Identifier Type: OTHER_GRANT

Identifier Source: secondary_id

IRB-300015105

Identifier Type: -

Identifier Source: org_study_id