Arterial Calcifications in Nocturnal Hemodialysis and Renal Transplantation Versus Conventional Dialysis

NCT ID: NCT00950573

Last Updated: 2018-12-19

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

184 participants

Study Classification

OBSERVATIONAL

Study Start Date

2010-01-31

Study Completion Date

2018-12-12

Brief Summary

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Objective:

1. To assess whether nocturnal hemodialysis and renal transplantation are associated with less progression of coronary arterial calcification, compared with conventional hemodialysis and peritoneal dialysis;
2. To identify the risk factors for coronary arterial calcification in dialysis and transplant patients, and to assess a possible interaction with treatment modality.

Detailed Description

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To assess whether nocturnal hemodialysis and renal transplantation are associated with less progression of coronary arterial calcification, compared with conventional hemodialysis and peritoneal dialysis; To identify the risk factors for coronary arterial calcification in dialysis and transplant patients, and to assess a possible interaction with treatment modality.

Conditions

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Kidney Disease

Keywords

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cardiovascular disease endstage renal disease

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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hemodialysis

patients treated with conventional hemodialysis

No interventions assigned to this group

peritoneal dialysis

patients treated with peritoneal dialysis

No interventions assigned to this group

nocturnal hemodialysis

patients treated with frequent nocturnal hemodialysis

No interventions assigned to this group

kidney transplantation

patients treated with renal transplantation

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* ESRD
* current age \> 18 and \< 75 yr
* ability to understand the study procedures
* willingness to provide written informed consent

Exclusion Criteria

* life expectancy \< 3 months
* claustrophobia
* allergy to iodinated contrast
* treatment incompliance, i.e. non-adherence to dialysis regimens and drug use
* GFR \< 30 ml/min (according to MDRD formula) in renal transplant patients
* pregnancy
Minimum Eligible Age

18 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Dianet Dialysis Centers

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Brigit van Jaarsveld, MD, PHD

Role: PRINCIPAL_INVESTIGATOR

Amsterdam UMC, location VUmc

Locations

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Dianet Dialysis Centers

Utrecht, , Netherlands

Site Status

University Medical Center Utrecht

Utrecht, , Netherlands

Site Status

Countries

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Netherlands

Other Identifiers

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NOCTX

Identifier Type: -

Identifier Source: org_study_id