The Fever and Antipyretic in Critically Illness Evaluation Study
NCT ID: NCT00940654
Last Updated: 2010-05-19
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
1426 participants
OBSERVATIONAL
2009-09-30
2009-12-31
Brief Summary
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Detailed Description
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It is unfortunate that there is not enough information on how the investigators should control body temperature in non-neurological critically ill patients, because fever is a very common physiological abnormality in this cohort. From the beginning, it would, therefore, be desirable to understand several aspects of fever and antipyretic therapy in ICU patients, as 1)How often fever occurs in our ICUs, 2)To what degree fever is independently associated with mortality?, 3)How often antipyretic therapy is prescribed?, 4)How effectively antipyretic can decrease temperature?, 5)How different is lowering temperature with medications compared with cooling?, 6)To what degree antipyretic is independently associated with mortality?
Thus, the investigators plan to address these questions by conducting a multi-national multi-center prospective observational trial, named "The Fever and Antipyretic in Critically illness evaluation study" (The FACE study)
Conditions
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Study Design
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CASE_CONTROL
PROSPECTIVE
Study Groups
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Patients with fever
Antipyretic therapy
External cooling;Internal cooling;Non steroid anti inflammatory drugs; Acetaminophen; Steroid
Patients without any fever
No interventions assigned to this group
Interventions
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Antipyretic therapy
External cooling;Internal cooling;Non steroid anti inflammatory drugs; Acetaminophen; Steroid
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* ICU patients expected to require intensive care for more than 48 hour.
Exclusion Criteria
20 Years
ALL
No
Sponsors
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Japanese Society of Intensive Care Medicine
OTHER
Responsible Party
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Japanese Society of Intensive Care Medicine
Principal Investigators
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Younsuck Koh, M.D. PhD
Role: STUDY_CHAIR
Korean Society of Critical Care Medicine
Masaji Nishimura, M.D. PhD
Role: STUDY_CHAIR
Japanese Society of Intensive Care Medicine
Jae Yeol Kim, M.D.
Role: PRINCIPAL_INVESTIGATOR
Korean Society of Critical Care Medicine
Gee Young Suh, M.D.
Role: PRINCIPAL_INVESTIGATOR
Korean Society of Critical Care Medicine
Moritoki Egi, M.D.
Role: PRINCIPAL_INVESTIGATOR
Japanese Society of Intensive Care Medicine
Locations
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The Japanese Society of Intensive Care Medicine
Bunkyo-ku, Tokyo, Japan
Korean Society of Critical Care Medicine
Songpa-gu, Seoul, South Korea
Countries
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References
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Lee BH, Inui D, Suh GY, Kim JY, Kwon JY, Park J, Tada K, Tanaka K, Ietsugu K, Uehara K, Dote K, Tajimi K, Morita K, Matsuo K, Hoshino K, Hosokawa K, Lee KH, Lee KM, Takatori M, Nishimura M, Sanui M, Ito M, Egi M, Honda N, Okayama N, Shime N, Tsuruta R, Nogami S, Yoon SH, Fujitani S, Koh SO, Takeda S, Saito S, Hong SJ, Yamamoto T, Yokoyama T, Yamaguchi T, Nishiyama T, Igarashi T, Kakihana Y, Koh Y; Fever and Antipyretic in Critically ill patients Evaluation (FACE) Study Group. Association of body temperature and antipyretic treatments with mortality of critically ill patients with and without sepsis: multi-centered prospective observational study. Crit Care. 2012 Feb 28;16(1):R33. doi: 10.1186/cc11211.
Related Links
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JSICM
Other Identifiers
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JSICM&KSCCM FACE
Identifier Type: -
Identifier Source: org_study_id
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