Radiation Therapy With or Without Androgen-Deprivation Therapy in Treating Patients With Prostate Cancer

NCT ID: NCT00936390

Last Updated: 2025-10-15

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: PHASE3
• Total Enrollment: 1538 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2009-09-30
• Study Completion Date: 2025-09-04

Brief Summary

RATIONALE: Radiation therapy uses high-energy x-rays and other types of radiation to kill tumor cells and shrink tumors. Androgens can cause the growth of prostate cancer cells. Androgen-deprivation therapy may lessen the amount of androgens made by the body. It is not yet known whether radiation therapy is more effective with or without androgen-deprivation therapy in treating patients with prostate cancer.

PURPOSE: This randomized phase III trial is studying radiation therapy to see how well it works compared with radiation therapy given together with androgen-deprivation therapy in treating patients with prostate cancer.

Detailed Description

OBJECTIVES:

Primary

• Demonstrate an overall survival (OS) advantage in patients with intermediate-risk prostate cancer treated with dose-escalated radiotherapy (RT) with versus without short-term androgen-deprivation therapy (ADT).

Secondary

• Determine whether the addition of ADT to dose-escalated RT versus RT alone improves clinical failures, biochemical failure by the "nadir +2", freedom from failure, rate of salvage ADT, and prostate cancer-specific mortality in these patients.
• Estimate the magnitude of benefit of ADT with respect to OS in patients treated with different RT modalities (i.e., external-beam radiation therapy alone vs low-dose rate brachytherapy boost vs high-dose rate brachytherapy boost).
• Compare acute and late treatment adverse events of these regimens and correlate these events with the presence or absence of pre-existing comorbidity as documented by the Adult Comorbidity Evaluation 27 assessment.

OUTLINE: This is a multicenter, dose-escalation study of radiotherapy. Patients are stratified according to number of risk factors (1 vs 2-3), comorbidity (ACE-27 grade ≥ 2 vs < 2), and radiotherapy (RT) modality (dose-escalated external-beam RT [EBRT] vs EBRT and low-dose rate brachytherapy boost vs EBRT and high-dose rate brachytherapy boost). Patients are randomized to 1 of 2 treatment arms. After completion of study therapy, patients are followed up periodically.

Conditions

Prostate Cancer

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Dose-Escalated Radiation Therapy Alone

Radiation therapy consists of 79.2 Gy EBRT only or 45 Gy EBRT followed by low- or high-dose rate brachytherapy. EBRT is delivered in 1.8 Gy daily fractions.

Group Type: ACTIVE_COMPARATOR

Dose-Escalated Radiation Therapy

Intervention Type: RADIATION

External beam radiotherapy (EBRT) as 3D Conformal Radiotherapy (3DCRT) or intensity-modulated radiation therapy (IMRT). Brachytherapy is optional, at the discretion of the treating physician. Patients treated entirely via EBRT receive 79.2 Gy delivered in 1.8 Gy fractions. Patients who receive brachytherapy as a component of their RT receive 45 Gy EBRT in 1.8 Gy fractions. Low-dose brachytherapy boost occurs following the EBRT portion of treatment no more than 4 weeks following its completion.High-dose rate brachytherapy boost is delivered in 2 fractions separated by a minimum time span of 6 hours and the implant(s) may be performed during the EBRT portion of the treatment or within 1 week prior to its initiation or following its completion.

Dose-Escalated Radiation Therapy and Short-Term Androgen-Deprivation

Radiation therapy consists of 79.2 Gy EBRT only or 45 Gy EBRT followed by low- or high-dose rate brachytherapy. EBRT is delivered in 1.8 Gy daily fractions.

Six months of androgen-deprivation therapy starts 8 weeks prior to start of radiation therapy and consists of luteinizing-hormone releasing-hormone (LHRH) agonist (antagonist) therapy (leuprolide, goserelin, buserelin. triptorelin, or degarelix) and anti-androgen therapy (bicalutamide or flutamide).

Group Type: EXPERIMENTAL

bicalutamide

Intervention Type: DRUG

Administered orally at a dose of one 50 mg tablet per day, beginning within (before, same day as, or after) 10 days of the date of the first LHRH agonist (antagonist) therapy administration and continuing for a total duration of 6 months.

flutamide

Intervention Type: DRUG

Administered orally at a dose of 250 mg (two 125-mg capsules) three times a day for a total daily dose of 750 mg, beginning within (before, same day as, or after) 10 days of with the date of the first LHRH agonist (antagonist) therapy administration and continuing for a total duration of 6 months.

LHRH agonist (antagonist) therapy

Intervention Type: DRUG

LHRH agonist (antagonist) therapy consists of leuprolide, goserelin, buserelin, triptorelin, or degarelix. The manufacturer's instructions should be followed. The first administration occurs with the start of anti-androgen treatment 8 weeks prior to the start of RT. The total duration of LHRH agonist (antagonist) therapy is 6 months.

Dose-Escalated Radiation Therapy

Intervention Type: RADIATION

External beam radiotherapy (EBRT) as 3D Conformal Radiotherapy (3DCRT) or intensity-modulated radiation therapy (IMRT). Brachytherapy is optional, at the discretion of the treating physician. Patients treated entirely via EBRT receive 79.2 Gy delivered in 1.8 Gy fractions. Patients who receive brachytherapy as a component of their RT receive 45 Gy EBRT in 1.8 Gy fractions. Low-dose brachytherapy boost occurs following the EBRT portion of treatment no more than 4 weeks following its completion.High-dose rate brachytherapy boost is delivered in 2 fractions separated by a minimum time span of 6 hours and the implant(s) may be performed during the EBRT portion of the treatment or within 1 week prior to its initiation or following its completion.

Interventions

bicalutamide

Administered orally at a dose of one 50 mg tablet per day, beginning within (before, same day as, or after) 10 days of the date of the first LHRH agonist (antagonist) therapy administration and continuing for a total duration of 6 months.

Intervention Type: DRUG

flutamide

Administered orally at a dose of 250 mg (two 125-mg capsules) three times a day for a total daily dose of 750 mg, beginning within (before, same day as, or after) 10 days of with the date of the first LHRH agonist (antagonist) therapy administration and continuing for a total duration of 6 months.

Intervention Type: DRUG

LHRH agonist (antagonist) therapy

LHRH agonist (antagonist) therapy consists of leuprolide, goserelin, buserelin, triptorelin, or degarelix. The manufacturer's instructions should be followed. The first administration occurs with the start of anti-androgen treatment 8 weeks prior to the start of RT. The total duration of LHRH agonist (antagonist) therapy is 6 months.

Intervention Type: DRUG

Dose-Escalated Radiation Therapy

External beam radiotherapy (EBRT) as 3D Conformal Radiotherapy (3DCRT) or intensity-modulated radiation therapy (IMRT). Brachytherapy is optional, at the discretion of the treating physician. Patients treated entirely via EBRT receive 79.2 Gy delivered in 1.8 Gy fractions. Patients who receive brachytherapy as a component of their RT receive 45 Gy EBRT in 1.8 Gy fractions. Low-dose brachytherapy boost occurs following the EBRT portion of treatment no more than 4 weeks following its completion.High-dose rate brachytherapy boost is delivered in 2 fractions separated by a minimum time span of 6 hours and the implant(s) may be performed during the EBRT portion of the treatment or within 1 week prior to its initiation or following its completion.

Intervention Type: RADIATION

Other Intervention Names

anti-androgen therapy; leuprolide; goserelin; buserelin; triptorelin; degarelix

Eligibility Criteria

Inclusion Criteria

1. Pathologically (histologically) proven diagnosis of prostatic adenocarcinoma, at intermediate risk for recurrence, within 180 days prior to registration as determined by having one or more of the following intermediate-risk features: Gleason score 7; prostate-specific antigen (PSA) >10 but ≤20; clinical stage T2b-T2c.

• Patients previously diagnosed with low risk (Gleason score ≤ 6, clinical stage < T2a, and PSA < 10) prostate cancer undergoing active surveillance who are re-biopsied and found to have intermediate risk disease according to the protocol criteria are eligible for enrollment within 180 days of the repeat biopsy procedure.

2. Clinically negative lymph nodes as established by imaging (pelvic +/- abdominal CT or MRI), nodal sampling, or dissection within 60 days prior to registration, except as noted immediately below:

• Patients with a single intermediate risk factor only do not require abdominopelvic imaging, but these studies may be obtained at the discretion of the treating physician. Patients with 2 or 3 risk factors are required to undergo pelvic +/- abdominal CT or MRI.
• Patients with lymph nodes equivocal or questionable by imaging are eligible without biopsy if the nodes are ≤1.5 cm; any node larger than this on imaging will require negative biopsy for eligibility.

3. No evidence of bone metastases (M0) on bone scan within 60 days prior to registration.

• Bone scan is not required for patients enrolled with a single intermediate risk factor only, but this scan may be obtained at the discretion of the treating physician. Patients with 2 or 3 risk factors will require a negative bone scan for eligibility.
• Equivocal bone scan findings are allowed if plain film x-rays are negative for metastasis.

4. History/physical examination (to include, at a minimum, digital rectal examination of the prostate and examination of the skeletal system and abdomen, and formal comorbidity assessment via the ACE-27 instrument) within 60 days prior to registration.

5. Zubrod Performance Status 0-1

6. Age ≥ 18

7. Baseline serum PSA value performed with an FDA-approved assay (e.g., Abbott, Hybritech) within 60 days prior to registration

• Study entry PSA must not be obtained during the following time frames: (1) 10-day period following prostate biopsy; (2) following initiation of ADT; (3) within 30 days after discontinuation of finasteride; or (4) within 90 days after discontinuation of dutasteride.

8. For patients undergoing brachytherapy only: complete blood count (CBC)/differential obtained within 60 days prior to registration, with adequate bone marrow function defined as follows:

• Absolute neutrophil count (ANC) ≥ 1,800 cells/mm3
• Platelets ≥ 100,000 cells/mm3
• Hemoglobin (Hgb) ≥ 8.0 g/dl (Note: The use of transfusion or other intervention to achieve Hgb ≥ 8.0 g/dl is acceptable.)

9. Patient must be able to provide study-specific informed consent prior to study entry.

Exclusion Criteria

1. Patients with Gleason Score ≥ 8; PSA > 20; OR Clinical Stage ≥ T3 are ineligible for this trial.

• Should findings of extracapsular extension or seminal vesicle invasion be noted on prostate MRI, this study, if used, will not render patients ineligible for accrual to this protocol. Primary tumor staging for eligibility purposes is to be based on palpable or core biopsy evidence only with respect to extracapsular extension or seminal vesicle involvement.

2. Patients with all three intermediate risk factors who also have ≥ 50% of the number of their biopsy cores positive for cancer are ineligible for this trial.

3. Prior invasive malignancy (except non-melanomatous skin cancer) or hematological (e.g., leukemia, lymphoma, myeloma) malignancy unless disease free for a minimum of 5 years (prior diagnoses of carcinoma in situ are permitted)

4. Prior radical surgery (prostatectomy), high-intensity focused ultrasound (HIFU) or cryosurgery for prostate cancer

5. Prior hormonal therapy, such as LHRH agonists (e.g., goserelin, leuprolide), antiandrogens (e.g., flutamide, bicalutamide), estrogens (e.g., DES), or bilateral orchiectomy

6. Use of finasteride within 30 days prior to registration

7. Use of dutasteride within 90 days prior to registration

8. Prior or concurrent cytotoxic chemotherapy for prostate cancer; prior chemotherapy for a different cancer is permitted.

9. Prior RT, including brachytherapy, to the region of the study cancer that would result in overlap of RT fields

• Any patient undergoing brachytherapy must have transrectal ultrasound confirmation of prostate volume <60 cc, American Urological Association Symptom Index (AUA-SI) score ≤15 within 60 days of registration, and no history of prior transurethral resection of the prostate (TURP); prior TURP is permitted for patients who receive EBRT only)

10. Severe, active co-morbidity, defined as follows:

• Unstable angina and/or congestive heart failure requiring hospitalization within the last 6 months
• Transmural myocardial infarction within the last 6 months
• Acute bacterial or fungal infection requiring intravenous antibiotics at the time of registration
• Chronic Obstructive Pulmonary Disease exacerbation or other respiratory illness requiring hospitalization or precluding study therapy within 30 days before registration
• Hepatic insufficiency resulting in clinical jaundice and/or coagulation defects; note, however, that laboratory tests for liver function and coagulation parameters are not required for entry into this protocol.
• Acquired Immune Deficiency Syndrome (AIDS) based upon current Centers for Disease Control and Prevention (CDC) definition; note, however, that HIV testing is not required for entry into this protocol. While the treatment employed in this study is not significantly immunosuppressive, it is felt that a diagnosis of AIDS associated with prostate cancer is likely to impact this study's primary endpoint of overall survival. Patients who are HIV seropositive but do not meet criteria for diagnosis of AIDS are eligible for study participation.

11. Men who are sexually active with a woman of child-bearing potential and not willing/able to use medically acceptable forms of contraception (e.g., surgical, barrier, medicinal) during protocol treatment and during the first 3 months after cessation of protocol treatment; this exclusion is necessary because the treatment involved in this study may be significantly teratogenic.

• Minimum Eligible Age: 18 Years
• Eligible Sex: MALE
• Accepts Healthy Volunteers: No

Sponsors

National Cancer Institute (NCI)

NIH

Sponsor Role: collaborator

NRG Oncology

OTHER

Sponsor Role: collaborator

Radiation Therapy Oncology Group

NETWORK

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Alvaro A. Martinez, MD, FACR

Role: STUDY_CHAIR

21st Century Oncology - Michigan Institute for Radiation Oncology

Locations

University of Alabama at Birmingham Cancer Center

Birmingham, Alabama, United States

Fairbanks Memorial Hospital

Fairbanks, Alaska, United States

Arizona Center for Cancer Care-Peoria

Peoria, Arizona, United States

Saint Joseph's Hospital and Medical Center

Phoenix, Arizona, United States

21st Century Oncology-Scottsdale

Scottsdale, Arizona, United States

Mayo Clinic in Arizona

Scottsdale, Arizona, United States

Arizona Oncology Services Foundation

Scottsdale, Arizona, United States

Arizona Oncology Associates-West Orange Grove

Tucson, Arizona, United States

Mercy Cancer Center-Hot Springs

Hot Springs, Arkansas, United States

Sutter Cancer Centers Radiation Oncology Services-Auburn

Auburn, California, United States

Alta Bates Summit Medical Center-Herrick Campus

Berkeley, California, United States

Providence Saint Joseph Medical Center/Disney Family Cancer Center

Burbank, California, United States

Sutter Cancer Centers Radiation Oncology Services-Cameron Park

Cameron Park, California, United States

Mercy San Juan Medical Center

Carmichael, California, United States

Enloe Medical Center

Chico, California, United States

21st Century Oncology - El Segundo

El Segundo, California, United States

Fresno Cancer Center

Fresno, California, United States

Saint Agnes Medical Center

Fresno, California, United States

Marin General Hospital

Greenbrae, California, United States

Veterans Administration Long Beach Medical Center

Long Beach, California, United States

Los Angeles County-USC Medical Center

Los Angeles, California, United States

USC / Norris Comprehensive Cancer Center

Los Angeles, California, United States

Memorial Medical Center

Modesto, California, United States

Kaiser Permanente Oakland-Broadway

Oakland, California, United States

Kaiser Permanente-Oakland

Oakland, California, United States

Desert Regional Medical Center

Palm Springs, California, United States

Stanford Cancer Institute

Palo Alto, California, United States

Feather River Cancer Center

Paradise, California, United States

Pomona Valley Hospital Medical Center

Pomona, California, United States

Kaiser Permanente-Rancho Cordova Cancer Center

Rancho Cordova, California, United States

Kaiser Permanente-Redwood City

Redwood City, California, United States

Kaiser Permanente-Richmond

Richmond, California, United States

Rohnert Park Cancer Center

Rohnert Park, California, United States

Kaiser Permanente-Roseville

Roseville, California, United States

Sutter Cancer Centers Radiation Oncology Services-Roseville

Roseville, California, United States

The Permanente Medical Group-Roseville Radiation Oncology

Roseville, California, United States

Sutter General Hospital

Sacramento, California, United States

University of California Davis Comprehensive Cancer Center

Sacramento, California, United States

Mercy General Hospital Radiation Oncology Center

Sacramento, California, United States

Kaiser Permanente-South Sacramento

Sacramento, California, United States

South Sacramento Cancer Center

Sacramento, California, United States

Kaiser Permanente - Sacramento

Sacramento, California, United States

University of California San Diego

San Diego, California, United States

Kaiser Permanente-San Francisco

San Francisco, California, United States

UCSF Medical Center-Mount Zion

San Francisco, California, United States

California Pacific Medical Center-Pacific Campus

San Francisco, California, United States

Kaiser Permanente-Santa Teresa-San Jose

San Jose, California, United States

Kaiser Permanente San Leandro

San Leandro, California, United States

Kaiser Permanente-San Rafael

San Rafael, California, United States

Kaiser Permanente Medical Center - Santa Clara

Santa Clara, California, United States

Kaiser Permanente-Santa Rosa

Santa Rosa, California, United States

Kaiser Permanente Cancer Treatment Center

South San Francisco, California, United States

Kaiser Permanente-South San Francisco

South San Francisco, California, United States

Kaiser Permanente-Stockton

Stockton, California, United States

David Grant United States Air Force Medical Center

Travis Air Force Base, California, United States

Tahoe Forest Cancer Center

Truckee, California, United States

Sutter Cancer Centers Radiation Oncology Services-Vacaville

Vacaville, California, United States

Sutter Solano Medical Center/Cancer Center

Vallejo, California, United States

Kaiser Permanente-Walnut Creek

Walnut Creek, California, United States

Rocky Mountain Cancer Centers-Aurora

Aurora, Colorado, United States

University of Colorado Cancer Center - Anschutz Cancer Pavilion

Aurora, Colorado, United States

The Urology Center of Colorado

Denver, Colorado, United States

The Shaw Regional Cancer Center

Edwards, Colorado, United States

Poudre Valley Hospital

Fort Collins, Colorado, United States

Saint Mary's Hospital and Regional Medical Center

Grand Junction, Colorado, United States

Rocky Mountain Cancer Centers-Littleton

Littleton, Colorado, United States

Hartford Hospital

Hartford, Connecticut, United States

Saint Francis Hospital and Medical Center

Hartford, Connecticut, United States

Midstate Medical Center

Meriden, Connecticut, United States

The Hospital of Central Connecticut

New Britain, Connecticut, United States

Yale-New Haven Hospital Saint Raphael Campus

New Haven, Connecticut, United States

Helen F Graham Cancer Center

Newark, Delaware, United States

Christiana Care Health System-Christiana Hospital

Newark, Delaware, United States

University of Miami Sylvester Comprehensive Cancer Center at Deerfield Beach

Deerfield Beach, Florida, United States

Broward Health Medical Center

Fort Lauderdale, Florida, United States

Mayo Clinic in Florida

Jacksonville, Florida, United States

Florida Hospital Kissimmee

Kissimmee, Florida, United States

Lakeland Regional Cancer Center

Lakeland, Florida, United States

The Watson Clinic

Lakeland, Florida, United States

Jackson Memorial Hospital-Holtz Children's Hospital

Miami, Florida, United States

University of Miami Miller School of Medicine-Sylvester Cancer Center

Miami, Florida, United States

South Miami Hospital

Miami, Florida, United States

Florida Hospital Orlando

Orlando, Florida, United States

Bay Medical Center

Panama City, Florida, United States

James A. Haley Veterans Affairs Hospital

Tampa, Florida, United States

Grady Health System

Atlanta, Georgia, United States

Piedmont Hospital

Atlanta, Georgia, United States

Emory University/Winship Cancer Institute

Atlanta, Georgia, United States

Northside Hospital

Atlanta, Georgia, United States

John B Amos Cancer Center

Columbus, Georgia, United States

Northside Hospital-Forsyth

Cumming, Georgia, United States

Atlanta VA Medical Center

Decatur, Georgia, United States

Piedmont Fayette Hospital

Fayetteville, Georgia, United States

Northeast Georgia Medical Center

Gainesville, Georgia, United States

Memorial University Medical Center

Savannah, Georgia, United States

Lewis Cancer and Research Pavilion at Saint Joseph's/Candler

Savannah, Georgia, United States

Queen's Medical Center

Honolulu, Hawaii, United States

University of Hawaii Cancer Center

Honolulu, Hawaii, United States

The Cancer Center of Hawaii-Liliha

Honolulu, Hawaii, United States

Saint Alphonsus Cancer Care Center-Boise

Boise, Idaho, United States

Idaho Urologic Institute-Meridian

Meridian, Idaho, United States

Kootenai Cancer Center

Post Falls, Idaho, United States

Saint Anthony's Health

Alton, Illinois, United States

Memorial Hospital of Carbondale

Carbondale, Illinois, United States

Northwestern University

Chicago, Illinois, United States

John H Stroger Jr Hospital of Cook County

Chicago, Illinois, United States

University of Chicago Comprehensive Cancer Center

Chicago, Illinois, United States

Advocate Illinois Masonic Medical Center

Chicago, Illinois, United States

Decatur Memorial Hospital

Decatur, Illinois, United States

Crossroads Cancer Center

Effingham, Illinois, United States

Hines Veterans Administration Hospital

Hines, Illinois, United States

Loyola University Medical Center

Maywood, Illinois, United States

Pekin Cancer Treatment Center

Pekin, Illinois, United States

OSF Saint Francis Medical Center Radiation Oncology Service at the Central Illinois Comprehensive CC

Peoria, Illinois, United States

OSF Saint Francis Medical Center

Peoria, Illinois, United States

SwedishAmerican Regional Cancer Center/ACT

Rockford, Illinois, United States

Saint John's Hospital

Springfield, Illinois, United States

Memorial Medical Center

Springfield, Illinois, United States

Memorial and Saint Elizabeth's Health Care Services LLP

Swansea, Illinois, United States

Saint Vincent Anderson Regional Hospital/Cancer Center

Anderson, Indiana, United States

IU Health West Hospital

Avon, Indiana, United States

IU Health Bloomington

Bloomington, Indiana, United States

Radiation Oncology Associates PC

Fort Wayne, Indiana, United States

Parkview Hospital Randallia

Fort Wayne, Indiana, United States

IU Health Goshen Center for Cancer Care

Goshen, Indiana, United States

Indiana University/Melvin and Bren Simon Cancer Center

Indianapolis, Indiana, United States

IU Health Methodist Hospital

Indianapolis, Indiana, United States

Richard L. Roudebush Veterans Affairs Medical Center

Indianapolis, Indiana, United States

IU Health Central Indiana Cancer Centers-East

Indianapolis, Indiana, United States

McFarland Clinic PC-William R Bliss Cancer Center

Ames, Iowa, United States

Medical Oncology and Hematology Associates-West Des Moines

Clive, Iowa, United States

Iowa Methodist Medical Center

Des Moines, Iowa, United States

Iowa Oncology Research Association CCOP

Des Moines, Iowa, United States

Medical Oncology and Hematology Associates-Des Moines

Des Moines, Iowa, United States

Medical Oncology and Hematology Associates-Laurel

Des Moines, Iowa, United States

Mercy Medical Center - Des Moines

Des Moines, Iowa, United States

Iowa Lutheran Hospital

Des Moines, Iowa, United States

Finley Hospital

Dubuque, Iowa, United States

Cancer Center of Kansas - Dodge City

Dodge City, Kansas, United States

Cancer Center of Kansas - El Dorado

El Dorado, Kansas, United States

Lawrence Memorial Hospital

Lawrence, Kansas, United States

Kansas City Cancer Centers-Southwest

Overland Park, Kansas, United States

Cancer Center of Kansas - Wellington

Wellington, Kansas, United States

Associates In Womens Health

Wichita, Kansas, United States

Cancer Center of Kansas-Wichita Medical Arts Tower

Wichita, Kansas, United States

Cancer Center of Kansas - Main Office

Wichita, Kansas, United States

Via Christi Regional Medical Center

Wichita, Kansas, United States

Wesley Medical Center

Wichita, Kansas, United States

Wichita CCOP

Wichita, Kansas, United States

Cancer Center of Kansas - Winfield

Winfield, Kansas, United States

Baptist Health Lexington

Lexington, Kentucky, United States

University of Kentucky/Markey Cancer Center

Lexington, Kentucky, United States

The James Graham Brown Cancer Center at University of Louisville

Louisville, Kentucky, United States

Owensboro Health Mitchell Memorial Cancer Center

Owensboro, Kentucky, United States

Mary Bird Perkins Cancer Center

Baton Rouge, Louisiana, United States

Tulane University Health Sciences Center

New Orleans, Louisiana, United States

Ochsner Medical Center Jefferson

New Orleans, Louisiana, United States

Central Maine Medical Center

Lewiston, Maine, United States

Maine Medical Center- Scarborough Campus

Scarborough, Maine, United States

Anne Arundel Medical Center

Annapolis, Maryland, United States

University of Maryland/Greenebaum Cancer Center

Baltimore, Maryland, United States

Greater Baltimore Medical Center

Baltimore, Maryland, United States

Saint Agnes Hospital

Baltimore, Maryland, United States

Upper Chesapeake Medical Center

Bel Air, Maryland, United States

Walter Reed National Military Medical Center

Bethesda, Maryland, United States

Central Maryland Radiation Oncology in Howard County

Columbia, Maryland, United States

Tate Cancer Center

Glen Burnie, Maryland, United States

Holy Cross Hospital

Silver Spring, Maryland, United States

Massachusetts General Hospital Cancer Center

Boston, Massachusetts, United States

Boston Medical Center

Boston, Massachusetts, United States

Mass General/North Shore Cancer Center

Danvers, Massachusetts, United States

Saint Anne's Hospital

Fall River, Massachusetts, United States

Cape Cod Hospital

Hyannis, Massachusetts, United States

Lowell General Hospital

Lowell, Massachusetts, United States

Berkshire Hematology Oncology PC

Pittsfield, Massachusetts, United States

Beth Israel Deaconess Hospital-Plymouth

Plymouth, Massachusetts, United States

D'Amour Center for Cancer Care

Springfield, Massachusetts, United States

Baystate Medical Center

Springfield, Massachusetts, United States

Saint Vincent Hospital/Reliant Medical Group

Worcester, Massachusetts, United States

Bixby Medical Center

Adrian, Michigan, United States

Veteran's Administration Medical Center - Ann Arbor

Ann Arbor, Michigan, United States

Saint Joseph Mercy Hospital

Ann Arbor, Michigan, United States

University of Michigan Comprehensive Cancer Center

Ann Arbor, Michigan, United States

Bronson Battle Creek

Battle Creek, Michigan, United States

McLaren-Bay Region

Bay City, Michigan, United States

Henry Ford Macomb Hospital

Clinton Township, Michigan, United States

Huron Valley-Sinai Hospital

Commerce, Michigan, United States

Henry Ford Hospital

Detroit, Michigan, United States

Saint John Hospital and Medical Center

Detroit, Michigan, United States

Green Bay Oncology - Escanaba

Escanaba, Michigan, United States

Botsford General Hospital

Farmington, Michigan, United States

21st Century Oncology-Farmington Hills

Farmington Hills, Michigan, United States

Genesys Hurley Cancer Institute

Flint, Michigan, United States

Genesys Regional Medical Center-West Flint Campus

Flint, Michigan, United States

McLaren-Flint

Flint, Michigan, United States

Mercy Health Saint Mary's

Grand Rapids, Michigan, United States

Spectrum Health at Butterworth Campus

Grand Rapids, Michigan, United States

Green Bay Oncology - Iron Mountain

Iron Mountain, Michigan, United States

Borgess Medical Center

Kalamazoo, Michigan, United States

Bronson Methodist Hospital

Kalamazoo, Michigan, United States

West Michigan Cancer Center

Kalamazoo, Michigan, United States

Sparrow Hospital

Lansing, Michigan, United States

Great Lakes Cancer Institute-Lapeer Campus

Lapeer, Michigan, United States

McLaren-Macomb

Mount Clemens, Michigan, United States

McLaren-Central Michigan

Mount Pleasant, Michigan, United States

Mercy Health Mercy Campus

Muskegon, Michigan, United States

McLaren Cancer Institute-Owosso

Owosso, Michigan, United States

Northern Michigan Regional Hospital

Petoskey, Michigan, United States

Saint Joseph Mercy Oakland

Pontiac, Michigan, United States

Saint Joseph Mercy Port Huron

Port Huron, Michigan, United States

Crittenton Hospital

Rochester, Michigan, United States

William Beaumont Hospital-Royal Oak

Royal Oak, Michigan, United States

Saint Mary's of Michigan

Saginaw, Michigan, United States

Downriver Center for Oncology

Trenton, Michigan, United States

21st Century Oncology-Troy

Troy, Michigan, United States

William Beaumont Hospital - Troy

Troy, Michigan, United States

Saint John Macomb-Oakland Hospital

Warren, Michigan, United States

Henry Ford West Bloomfield Hospital

West Bloomfield, Michigan, United States

Mayo Clinic Health System in Albert Lea

Albert Lea, Minnesota, United States

Sanford Clinic North-Bemidgi

Bemidji, Minnesota, United States

Miller-Dwan Hospital

Duluth, Minnesota, United States

Saint Luke's Hospital of Duluth

Duluth, Minnesota, United States

Fairview-Southdale Hospital

Edina, Minnesota, United States

Mayo Clinic Health Systems-Mankato

Mankato, Minnesota, United States

Mayo Clinic

Rochester, Minnesota, United States

Regions Hospital

Saint Paul, Minnesota, United States

Saint Francis Medical Center

Cape Girardeau, Missouri, United States

Siteman Cancer Center - Saint Peters

City of Saint Peters, Missouri, United States

Mercy Hospital-Joplin

Joplin, Missouri, United States

Kansas City Cancer Center - South

Kansas City, Missouri, United States

Kansas City Cancer Centers - North

Kansas City, Missouri, United States

Kansas City Cancer Center-Lee's Summit

Lee's Summit, Missouri, United States

Phelps County Regional Medical Center

Rolla, Missouri, United States

Cancer Research for the Ozarks NCORP

Springfield, Missouri, United States

Mercy Hospital Springfield

Springfield, Missouri, United States

CoxHealth South Hospital

Springfield, Missouri, United States

Washington University School of Medicine

St Louis, Missouri, United States

Siteman Cancer Center-South County

St Louis, Missouri, United States

Missouri Baptist Medical Center

St Louis, Missouri, United States

Barnes-Jewish West County Hospital

St Louis, Missouri, United States

Mercy Hospital Saint Louis

St Louis, Missouri, United States

Saint Louis-Cape Girardeau CCOP

St Louis, Missouri, United States

Montana Cancer Consortium CCOP

Billings, Montana, United States

Northern Rockies Radiation Oncology Center

Billings, Montana, United States

Billings Clinic Cancer Center

Billings, Montana, United States

Berdeaux, Donald MD (UIA Investigator)

Great Falls, Montana, United States

Great Falls Clinic

Great Falls, Montana, United States

Saint Elizabeth Regional Medical Center

Lincoln, Nebraska, United States

Missouri Valley Cancer Consortium

Omaha, Nebraska, United States

Nebraska Methodist Hospital

Omaha, Nebraska, United States

Alegent Health Immanuel Medical Center

Omaha, Nebraska, United States

Alegent Health Bergan Mercy Medical Center

Omaha, Nebraska, United States

Alegent Health Lakeside Hospital

Omaha, Nebraska, United States

Creighton University Medical Center

Omaha, Nebraska, United States

University of Nebraska Medical Center

Omaha, Nebraska, United States

Concord Hospital

Concord, New Hampshire, United States

Exeter Hospital

Exeter, New Hampshire, United States

Cheshire Medical Center-Dartmouth-Hitchcock Keene

Keene, New Hampshire, United States

Dartmouth Hitchcock Medical Center

Lebanon, New Hampshire, United States

Elliot Hospital

Manchester, New Hampshire, United States

Ocean Medical Center

Brick, New Jersey, United States

Cooper Hospital University Medical Center

Camden, New Jersey, United States

Veterans Adminstration New Jersey Health Care System

East Orange, New Jersey, United States

CentraState Medical Center

Freehold, New Jersey, United States

Princeton Radiation Oncology Center

Monroe, New Jersey, United States

Fox Chase Cancer Center at Virtua Memorial Hospital of Burlington County

Mount Holly, New Jersey, United States

Jersey Shore Medical Center

Neptune City, New Jersey, United States

Rutgers Cancer Institute of New Jersey

New Brunswick, New Jersey, United States

UMDNJ - Robert Wood Johnson University Hospital

New Brunswick, New Jersey, United States

UMDNJ - New Jersey Medical School

Newark, New Jersey, United States

Newark Beth Israel Medical Center

Newark, New Jersey, United States

The Medical Center At Princeton

Princeton, New Jersey, United States

Riverview Medical Center/Booker Cancer Center

Red Bank, New Jersey, United States

Sparta Cancer Treatment Center

Sparta, New Jersey, United States

Community Medical Center

Toms River, New Jersey, United States

MD Anderson Cancer Center at Cooper-Voorhees

Voorhees Township, New Jersey, United States

Virtua West Jersey Hospital Voorhees

Voorhees Township, New Jersey, United States

Prostate Cancer Center of New Jersey

West Orange, New Jersey, United States

Lovelace Medical Center-Downtown

Albuquerque, New Mexico, United States

University of New Mexico

Albuquerque, New Mexico, United States

University of New Mexico Cancer Center

Albuquerque, New Mexico, United States

Radiation Oncology Associates

Albuquerque, New Mexico, United States

Memorial Medical Center - Las Cruces

Las Cruces, New Mexico, United States

New York Oncology Hematology PC - Albany

Albany, New York, United States

Saint Peters Hospital-Albany

Albany, New York, United States

Southside Hospital

Bay Shore, New York, United States

Lourdes Hospital

Binghamton, New York, United States

State University of New York Downstate Medical Center

Brooklyn, New York, United States

Veteran Affairs New York Harbor Healthcare System-Brooklyn Campus

Brooklyn, New York, United States

Roswell Park Cancer Institute

Buffalo, New York, United States

Sands Cancer Center

Canandaigua, New York, United States

Mary Imogene Bassett Hospital

Cooperstown, New York, United States

Arnot Ogden Medical Center/Falck Cancer Center

Elmira, New York, United States

North Shore University Hospital

Manhasset, New York, United States

North Shore-LIJ Health System NCORP

Manhasset, New York, United States

Long Island Jewish Medical Center

New Hyde Park, New York, United States

North Shore-LIJ Health System/Center for Advanced Medicine

New Hyde Park, New York, United States

Columbia University Medical Center

New York, New York, United States

Hudson Valley Oncology Associates

Poughkeepsie, New York, United States

Highland Hospital

Rochester, New York, United States

University Radiation Oncology

Rochester, New York, United States

University of Rochester

Rochester, New York, United States

Randolph Hospital

Asheboro, North Carolina, United States

University of North Carolina at Chapel Hill

Chapel Hill, North Carolina, United States

Duke University Medical Center

Durham, North Carolina, United States

Cone Health Cancer Center

Greensboro, North Carolina, United States

The Coleman Radiation Center-Carteret General Hospital

Morehead City, North Carolina, United States

CarolinaEast Health System-Medical Center

New Bern, North Carolina, United States

Duke Cancer Institute Macon Pond

Raleigh, North Carolina, United States

Rex Cancer Center

Raleigh, North Carolina, United States

South Atlantic Radiation Oncology

Supply, North Carolina, United States

Coastal Carolina Radiation Oncology

Wilmington, North Carolina, United States

New Hanover Regional Medical Center/Zimmer Cancer Center

Wilmington, North Carolina, United States

Southeast Cancer Consortium-Upstate NCORP

Winston-Salem, North Carolina, United States

Mid Dakota Clinic

Bismarck, North Dakota, United States

Saint Alexius Medical Center

Bismarck, North Dakota, United States

Sanford Bismarck Medical Center

Bismarck, North Dakota, United States

Sanford Clinic North-Fargo

Fargo, North Dakota, United States

Sanford Medical Center-Fargo

Fargo, North Dakota, United States

Trinity Cancer Care Center

Minot, North Dakota, United States

Summa Akron City Hospital/Cooper Cancer Center

Akron, Ohio, United States

Akron General Medical Center

Akron, Ohio, United States

Summa Barberton Hospital

Barberton, Ohio, United States

UHHS-Chagrin Highlands Medical Center

Beachwood, Ohio, United States

Geaugra Hospital

Chardon, Ohio, United States

Adena Regional Medical Center

Chillicothe, Ohio, United States

University of Cincinnati

Cincinnati, Ohio, United States

Case Western Reserve University

Cleveland, Ohio, United States

Cleveland Clinic Cancer Center/Fairview Hospital

Cleveland, Ohio, United States

Cleveland Clinic Foundation

Cleveland, Ohio, United States

Ohio State University Comprehensive Cancer Center

Columbus, Ohio, United States

Riverside Methodist Hospital

Columbus, Ohio, United States

Columbus CCOP

Columbus, Ohio, United States

Grant Medical Center

Columbus, Ohio, United States

The Mark H Zangmeister Center

Columbus, Ohio, United States

Mount Carmel Health Center West

Columbus, Ohio, United States

Doctors Hospital

Columbus, Ohio, United States

Grady Memorial Hospital

Delaware, Ohio, United States

Mercy Cancer Center-Elyria

Elyria, Ohio, United States

Cleveland Clinic Cancer Center Independence

Independence, Ohio, United States

Marietta Memorial Hospital

Marietta, Ohio, United States

Toledo Clinic Cancer Centers-Maumee

Maumee, Ohio, United States

Hillcrest Hospital Cancer Center

Mayfield Heights, Ohio, United States

Summa Health Center at Lake Medina

Medina, Ohio, United States

Lake University Ireland Cancer Center

Mentor, Ohio, United States

Southwest General Health Center Ireland Cancer Center

Middleburg Heights, Ohio, United States

Licking Memorial Hospital

Newark, Ohio, United States

Saint Charles Hospital

Oregon, Ohio, United States

University Hospitals Parma Medical Center

Parma, Ohio, United States

Southern Ohio Medical Center

Portsmouth, Ohio, United States

Robinson Radiation Oncology

Ravenna, Ohio, United States

Cancer Care Center, Incorporated

Salem, Ohio, United States

Ireland Cancer Center at Firelands Regional Medical Center

Sandusky, Ohio, United States

North Coast Cancer Care

Sandusky, Ohio, United States

Flower Hospital

Sylvania, Ohio, United States

University of Toledo

Toledo, Ohio, United States

Mercy Saint Anne Hospital

Toledo, Ohio, United States

University Pointe

West Chester, Ohio, United States

Saint Ann's Hospital

Westerville, Ohio, United States

UHHS-Westlake Medical Center

Westlake, Ohio, United States

Cancer Treatment Center

Wooster, Ohio, United States

Cleveland Clinic Wooster Specialty Center

Wooster, Ohio, United States

Wright-Patterson Medical Center

Wright-Patterson Air Force Base, Ohio, United States

Genesis HealthCare System

Zanesville, Ohio, United States

University of Oklahoma Health Sciences Center

Oklahoma City, Oklahoma, United States

Clackamas Radiation Oncology Center

Clackamas, Oregon, United States

Willamette Valley Cancer Center

Eugene, Oregon, United States

Three Rivers Community Hospital

Grants Pass, Oregon, United States

Legacy Mount Hood Medical Center

Gresham, Oregon, United States

Asante Health System

Medford, Oregon, United States

Providence Medford Medical Center

Medford, Oregon, United States

Rogue Valley Medical Center

Medford, Oregon, United States

Providence Milwaukie Hospital

Milwaukie, Oregon, United States

Legacy Good Samaritan Hospital and Medical Center

Portland, Oregon, United States

Providence Portland Medical Center

Portland, Oregon, United States

Western Oncology Research Consortium

Portland, Oregon, United States

Providence Saint Vincent Medical Center

Portland, Oregon, United States

Legacy Meridian Park Hospital

Tualatin, Oregon, United States

Abington Memorial Hospital

Abington, Pennsylvania, United States

Saint Luke's University Hospital-Bethlehem Campus

Bethlehem, Pennsylvania, United States

Bryn Mawr Hospital

Bryn Mawr, Pennsylvania, United States

Geisinger Medical Center

Danville, Pennsylvania, United States

Mercy Fitzgerald Hospital

Darby, Pennsylvania, United States

Delaware County Memorial Hospital

Drexel Hill, Pennsylvania, United States

Northeast Radiation Oncology Center

Dunmore, Pennsylvania, United States

The Regional Cancer Center

Erie, Pennsylvania, United States

Fox Chase Cancer Center Buckingham

Furlong, Pennsylvania, United States

Adams Cancer Center

Gettysburg, Pennsylvania, United States

Cherry Tree Cancer Center

Hanover, Pennsylvania, United States

Penn State Milton S Hershey Medical Center

Hershey, Pennsylvania, United States

Academic Urology Prostate Center

King of Prussia, Pennsylvania, United States

Saint Mary Medical and Regional Cancer Center

Langhorne, Pennsylvania, United States

Upper Delaware Valley Cancer Center

Milford, Pennsylvania, United States

Paoli Memorial Hospital

Paoli, Pennsylvania, United States

Thomas Jefferson University Hospital

Philadelphia, Pennsylvania, United States

Fox Chase Cancer Center

Philadelphia, Pennsylvania, United States

Temple University Hospital

Philadelphia, Pennsylvania, United States

Albert Einstein Medical Center

Philadelphia, Pennsylvania, United States

VA Pittsburgh Healthcare System

Pittsburgh, Pennsylvania, United States

Reading Hospital

West Reading, Pennsylvania, United States

Lankenau Medical Center

Wynnewood, Pennsylvania, United States

Mainline Health CCOP

Wynnewood, Pennsylvania, United States

WellSpan Health-York Hospital

York, Pennsylvania, United States

AnMed Health Hospital

Anderson, South Carolina, United States

Medical University of South Carolina

Charleston, South Carolina, United States

Greenville Health System Cancer Institute-Faris

Greenville, South Carolina, United States

Greenville Health System Cancer Institute-Eastside

Greenville, South Carolina, United States

Self Regional Healthcare

Greenwood, South Carolina, United States

Greenville Health System Cancer Institute-Greer

Greer, South Carolina, United States

Gibbs Cancer Center-Pelham

Greer, South Carolina, United States

Carolina Regional Cancer Center

Myrtle Beach, South Carolina, United States

Greenville Health System Cancer Institute-Seneca

Seneca, South Carolina, United States

Spartanburg Medical Center

Spartanburg, South Carolina, United States

Greenville Health System Cancer Institute-Spartanburg

Spartanburg, South Carolina, United States

Rapid City Regional Hospital

Rapid City, South Dakota, United States

Wellmont Holston Valley Hospital and Medical Center

Kingsport, Tennessee, United States

Thompson Cancer Survival Center

Knoxville, Tennessee, United States

Blount Memorial Hospital

Maryville, Tennessee, United States

Texas Oncology-Arlington South

Arlington, Texas, United States

Texas Oncology-Austin Midtown

Austin, Texas, United States

Texas Oncology - Central Austin Cancer Center

Austin, Texas, United States

Texas Oncology - South Austin Cancer Center

Austin, Texas, United States

Texas Oncology Bedford

Bedford, Texas, United States

Texas Cancer Center - Medical City Dallas

Dallas, Texas, United States

Texas Oncology Methodist Charlton Cancer Center

Dallas, Texas, United States

UT Southwestern/Simmons Cancer Center-Dallas

Dallas, Texas, United States

Texas Oncology-Denton South

Denton, Texas, United States

Brooke Army Medical Center

Fort Sam Houston, Texas, United States

The Klabzuba Cancer Center

Fort Worth, Texas, United States

University of Texas Medical Branch

Galveston, Texas, United States

Memorial Hermann Memorial City Medical Center

Houston, Texas, United States

M D Anderson Cancer Center

Houston, Texas, United States

UTMB Cancer Center at Victory Lakes

League City, Texas, United States

Texas Oncology - Lewisville

Lewisville, Texas, United States

Texas Oncology-Longview Cancer Center

Longview, Texas, United States

West Texas Cancer Center

Odessa, Texas, United States

Texas Oncology-Seton Williamson

Round Rock, Texas, United States

Texas Oncology - Round Rock Cancer Center

Round Rock, Texas, United States

Texas Cancer Center-Sherman

Sherman, Texas, United States

Texas Oncology Cancer Center Sugar Land

Sugar Land, Texas, United States

Texas Oncology-Wichita Falls Texoma Cancer Center

Wichita Falls, Texas, United States

Sandra L Maxwell Cancer Center

Cedar City, Utah, United States

Intermountain Medical Center

Murray, Utah, United States

McKay-Dee Hospital Center

Ogden, Utah, United States

Utah Valley Regional Medical Center

Provo, Utah, United States

Utah Cancer Specialists-Salt Lake City

Salt Lake City, Utah, United States

Huntsman Cancer Institute/University of Utah

Salt Lake City, Utah, United States

LDS Hospital

Salt Lake City, Utah, United States

Dixie Medical Center Regional Cancer Center

St. George, Utah, United States

Southwestern Vermont Medical Center

Bennington, Vermont, United States

Rutland Regional Medical Center

Rutland, Vermont, United States

Norris Cotton Cancer Center-North

Saint Johnsbury, Vermont, United States

Inova Alexandria Hospital

Alexandria, Virginia, United States

Danville Regional Medical Center

Danville, Virginia, United States

Augusta Health Cancer Center

Fishersville, Virginia, United States

Sentara Cancer Institute at Sentara CarePlex Hospital

Hampton, Virginia, United States

Sentara Rockingham Memorial Hospital Hahn Cancer Center

Harrisonburg, Virginia, United States

Sentara Hospitals

Norfolk, Virginia, United States

Southwest VA Regional Cancer Center

Norton, Virginia, United States

Naval Medical Center - Portsmouth

Portsmouth, Virginia, United States

Oncology and Hematology Associates of Southwest Virginia

Roanoke, Virginia, United States

Sentara Virginia Beach General Hospital

Virginia Beach, Virginia, United States

PeaceHealth Saint Joseph Medical Center

Bellingham, Washington, United States

Saint Francis Hospital

Federal Way, Washington, United States

Virginia Mason CCOP

Seattle, Washington, United States

Virginia Mason Medical Center

Seattle, Washington, United States

Cancer Care Northwest - Spokane South

Spokane, Washington, United States

Cancer Care Northwest-North Spokane

Spokane, Washington, United States

PeaceHealth Southwest Medical Center

Vancouver, Washington, United States

Compass Oncology Vancouver

Vancouver, Washington, United States

Legacy Salmon Creek Hospital

Vancouver, Washington, United States

Appleton Medical Center

Appleton, Wisconsin, United States

Green Bay Oncology at Saint Vincent Hospital

Green Bay, Wisconsin, United States

Bellin Memorial Hospital

Green Bay, Wisconsin, United States

Saint Vincent Hospital

Green Bay, Wisconsin, United States

Green Bay Oncology Limited at Saint Mary's Hospital

Green Bay, Wisconsin, United States

Saint Mary's Hospital

Green Bay, Wisconsin, United States

Aurora BayCare Medical Center

Green Bay, Wisconsin, United States

UW Cancer Center Johnson Creek

Johnson Creek, Wisconsin, United States

Gundersen Lutheran Medical Center

La Crosse, Wisconsin, United States

Mayo Clinic Health System-Franciscan Healthcare

La Crosse, Wisconsin, United States

Bay Area Medical Center

Marinette, Wisconsin, United States

Vince Lombardi Cancer Clinic-Marinette

Marinette, Wisconsin, United States

Community Memorial Hospital

Menomonee Falls, Wisconsin, United States

Columbia Saint Mary's Hospital - Ozaukee

Mequon, Wisconsin, United States

Columbia Saint Mary's Water Tower Medical Commons

Milwaukee, Wisconsin, United States

Aurora Saint Luke's Medical Center

Milwaukee, Wisconsin, United States

Froedtert and the Medical College of Wisconsin

Milwaukee, Wisconsin, United States

Zablocki Veterans Administration Medical Center

Milwaukee, Wisconsin, United States

Green Bay Oncology - Oconto Falls

Oconto Falls, Wisconsin, United States

Vince Lombardi Cancer Clinic - Oshkosh

Oshkosh, Wisconsin, United States

Wheaton Franciscan Cancer Care - All Saints

Racine, Wisconsin, United States

Door County Cancer Center

Sturgeon Bay, Wisconsin, United States

Green Bay Oncology - Sturgeon Bay

Sturgeon Bay, Wisconsin, United States

Aurora Medical Center in Summit

Summit, Wisconsin, United States

Aurora West Allis Medical Center

West Allis, Wisconsin, United States

The Alyce and Elmore Kraemer Cancer Care Center

West Bend, Wisconsin, United States

Riverview Hospital

Wisconsin Rapids, Wisconsin, United States

Welch Cancer Center

Sheridan, Wyoming, United States

Tom Baker Cancer Centre

Calgary, Alberta, Canada

Cross Cancer Institute

Edmonton, Alberta, Canada

BCCA-Cancer Centre for the Southern Interior

Kelowna, British Columbia, Canada

BCCA-Vancouver Island Cancer Centre

Victoria, British Columbia, Canada

Atlantic Health Sciences Corporation-Saint John Regional Hospital

Saint John, New Brunswick, Canada

QEII Health Sciences Centre/Capital District Health Authority

Halifax, Nova Scotia, Canada

Juravinski Cancer Centre at Hamilton Health Sciences

Hamilton, Ontario, Canada

London Regional Cancer Program

London, Ontario, Canada

Ottawa Health Research Institute-General Division

Ottawa, Ontario, Canada

Irving Greenberg Family Cancer Centre

Ottawa, Ontario, Canada

Thunder Bay Regional Health Science Centre

Thunder Bay, Ontario, Canada

Odette Cancer Centre- Sunnybrook Health Sciences Centre

Toronto, Ontario, Canada

Hopital Maisonneuve-Rosemont

Montreal, Quebec, Canada

CHUM - Hopital Notre-Dame

Montreal, Quebec, Canada

McGill University Department of Oncology

Montreal, Quebec, Canada

CHU de Quebec-L'Hotel-Dieu de Quebec (HDQ)

Québec, Quebec, Canada

Centre Hospitalier Universitaire de Sherbrooke-Fleurimont

Sherbrooke, Quebec, Canada

Allan Blair Cancer Centre

Regina, Saskatchewan, Canada

Saskatoon Cancer Centre

Saskatoon, Saskatchewan, Canada

Countries

United States; Canada

References

Krauss DJ, Karrison T, Martinez AA, Morton G, Yan D, Bruner DW, Movsas B, Elshaikh M, Citrin D, Hershatter B, Michalski JM, Efstathiou JA, Currey A, Kavadi VS, Cury FL, Lock M, Raben A, Seaward SA, El-Gayed A, Rodgers JP, Sandler HM. Dose-Escalated Radiotherapy Alone or in Combination With Short-Term Androgen Deprivation for Intermediate-Risk Prostate Cancer: Results of a Phase III Multi-Institutional Trial. J Clin Oncol. 2023 Jun 10;41(17):3203-3216. doi: 10.1200/JCO.22.02390. Epub 2023 Apr 27.

Reference Type: DERIVED

PMID: 37104748 (View on PubMed)

Provided Documents

Document Type: Study Protocol and Statistical Analysis Plan

View Document

Document Type: Informed Consent Form

View Document

Other Identifiers

CDR0000648194

Identifier Type: -

Identifier Source: secondary_id

NCI-2011-01948

Identifier Type: REGISTRY

Identifier Source: secondary_id

RTOG 0815

Identifier Type: -

Identifier Source: org_study_id