Prostate Radiation Therapy or Short-Term Androgen Deprivation Therapy and Pelvic Lymph Node Radiation Therapy With or Without Prostate Radiation Therapy in Treating Patients With a Rising Prostate Specific Antigen (PSA) After Surgery for Prostate Cancer

NCT ID: NCT00567580

Last Updated: 2025-05-09

Basic Information

• Recruitment Status: ACTIVE_NOT_RECRUITING
• Clinical Phase: PHASE3
• Total Enrollment: 1792 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2008-02-29

Brief Summary

RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. Androgens can cause the growth of prostate cancer cells. Antihormone therapy, such as flutamide, bicalutamide, and luteinizing hormone-releasing hormone agonist, may lessen the amount of androgens made by the body. It is not yet known which regimen of radiation therapy with or without androgen-deprivation therapy is more effective for prostate cancer.

PURPOSE: This randomized phase III trial is studying prostate radiation therapy to see how well it works compared with short-term androgen deprivation therapy given together with pelvic lymph node radiation therapy with or without prostate radiation therapy in treating patients with a rising PSA after surgery for prostate cancer.

Detailed Description

OBJECTIVES:

Primary

• To determine whether the addition of short-term androgen deprivation (STAD) to prostate bed radiotherapy (PBRT) improves freedom from progression (FFP) (i.e., maintenance of a prostate-specific antigen [PSA] less than the nadir+2 ng/mL, absence of clinical failure, and absence of death from any cause) for 5 years, over that of PBRT alone in men treated with salvage radiotherapy after radical prostatectomy.
• To determine whether STAD, pelvic lymph node radiotherapy (PLNRT), and PBRT improves FFP over that of STAD+PBRT and PBRT alone in men treated with salvage radiotherapy after radical prostatectomy.

Secondary

• To compare secondary biochemical failure, the development of hormone-refractory disease , distant metastasis, cause-specific mortality, and overall mortality at five years.
• To compare acute and late morbidity based on Common Toxicity Criteria for Adverse Effects (CTCAE), v. 3.0.
• To measure the expression of cell kinetic, apoptotic pathway, and angiogenesis-related genes in archival diagnostic tissue to better define the risk of FFP, distant failure, cause-specific mortality, and overall mortality after salvage radiotherapy for prostate cancer, independently of conventional clinical parameters now used.
• To quantify blood product-based proteomic and genomic (single nucleotide polymorphisms) patterns and urine-based genomic patterns before and at different times after treatment to better define the risk of FFP, distant failure, cause-specific mortality, and overall mortality after salvage radiotherapy for prostate cancer, independently of conventional clinical parameters now used.
• To assess the degree, duration, and significant differences of disease-specific health-related quality of life (HRQOL) decrements among treatment arms.
• To assess whether mood is improved and depression is decreased with the more aggressive therapy if it improves FFP.
• To collect paraffin-embedded tissue blocks, serum, plasma, urine, and buffy coat cells for future translational research analyses.

Tertiary

• To assess whether an incremental gain in FFP and survival with more aggressive therapy outweighs decrements in the primary generic domains of HRQOL (i.e., mobility, self care, usual activities, pain/discomfort, and anxiety/depression).
• To evaluate the cost-utility of the treatment arm demonstrating the most significant benefit (in terms of the primary outcome) in comparison with other widely accepted cancer and non-cancer therapies.
• To assess associations between serum levels of beta-amyloid and measures of cognition and mood and depression.
• An exploratory aim is to assess the relationship(s) between the American Urological Association Symptom Index (AUA SI) and urinary morbidity using the CTCAE v. 3.0 grading system.

OUTLINE: Patients are stratified according to seminal vesicle involvement (yes vs no), prostatectomy Gleason score (≤ 7 vs 8-9), pre-radiotherapy PSA (≥ 0.1 and ≤ 1.0 ng/mL vs > 1.0 and < 2.0 ng/mL), and pathology stage (pT2 and margin negative vs all others). Patients are randomized to 1 of 3 treatment arms.

Follow-up occurs 3, 6, and 12 months after the completion of radiation therapy, then every 6 months for 6 years, and then annually thereafter.

Conditions

Prostate Cancer

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

PBRT Alone

Prostate bed radiotherapy (PBRT) begins within 6 weeks (+/- 2 weeks) after registration.

Group Type: ACTIVE_COMPARATOR

PBRT

Intervention Type: RADIATION

1.8 Gy per fraction once daily, 5 days a week totaling 64.8-70.2 Gy. 3D-CRT or IMRT required.

PBRT + STAD

Prostate bed radiotherapy (PBRT) and short term androgen deprivation therapy (STAD) consisting of antiandrogen (AA) and luteinizing hormone-releasing hormone (LHRH) agonist therapy begins within 6 weeks (+/- 2 weeks) after registration. STAD starts first, 2 months (+/- 2 weeks) before radiotherapy (RT), and lasts for 4-6 months. LHRH can last 4-6 months. AA starts at the same time as LHRH (or up to 2 weeks prior ), lasts approximately 4 months, and should end on the last day of RT (+/- 2 weeks).

Group Type: EXPERIMENTAL

PBRT

Intervention Type: RADIATION

1.8 Gy per fraction once daily, 5 days a week totaling 64.8-70.2 Gy. 3D-CRT or IMRT required.

AA

Intervention Type: DRUG

Antiandrogen (AA) therapy can be either 250 mg flutamide by mouth three times a day or 50 mg bicalutamide by mouth once a day.

LHRH agonist

Intervention Type: DRUG

Luteinizing hormone-releasing hormone (LHRH) agonist can be any analog approved by the FDA (or by Health Canada for Canadian institutions) and may be given in any possible combination such that the total LHRH treatment time is 4-6 months. LHRH analogs are administered with a variety of techniques, including subcutaneous insertion of a solid plug in the abdominal wall, intramuscular injection, and subcutaneous injection.

PLNRT + PBRT + STADT

Pelvic lymph node radiotherapy (PLNRT), prostate bed radiotherapy (PBRT), and short term androgen deprivation therapy (STAD) consisting of antiandrogen (AA) and luteinizing hormone-releasing hormone (LHRH) agonist therapy begins within 6 weeks (+/- 2 weeks) after registration. STAD starts first, 2 months (+/- 2 weeks) before RT, and lasts for 4-6 months. LHRH can last 4-6 months. AA starts at the same time as LHRH (or up to 2 weeks prior ), lasts approximately 4 months, and should end on the last day of RT (+/- 2 weeks).

Group Type: EXPERIMENTAL

PBRT

Intervention Type: RADIATION

1.8 Gy per fraction once daily, 5 days a week totaling 64.8-70.2 Gy. 3D-CRT or IMRT required.

PLNRT

Intervention Type: RADIATION

1.8 Gy per fraction once daily, 5 days a week, totaling 45 Gy. 3D-CRT or IMRT required.

AA

Intervention Type: DRUG

Antiandrogen (AA) therapy can be either 250 mg flutamide by mouth three times a day or 50 mg bicalutamide by mouth once a day.

LHRH agonist

Intervention Type: DRUG

Luteinizing hormone-releasing hormone (LHRH) agonist can be any analog approved by the FDA (or by Health Canada for Canadian institutions) and may be given in any possible combination such that the total LHRH treatment time is 4-6 months. LHRH analogs are administered with a variety of techniques, including subcutaneous insertion of a solid plug in the abdominal wall, intramuscular injection, and subcutaneous injection.

Interventions

PBRT

1.8 Gy per fraction once daily, 5 days a week totaling 64.8-70.2 Gy. 3D-CRT or IMRT required.

Intervention Type: RADIATION

PLNRT

1.8 Gy per fraction once daily, 5 days a week, totaling 45 Gy. 3D-CRT or IMRT required.

Intervention Type: RADIATION

AA

Antiandrogen (AA) therapy can be either 250 mg flutamide by mouth three times a day or 50 mg bicalutamide by mouth once a day.

Intervention Type: DRUG

LHRH agonist

Luteinizing hormone-releasing hormone (LHRH) agonist can be any analog approved by the FDA (or by Health Canada for Canadian institutions) and may be given in any possible combination such that the total LHRH treatment time is 4-6 months. LHRH analogs are administered with a variety of techniques, including subcutaneous insertion of a solid plug in the abdominal wall, intramuscular injection, and subcutaneous injection.

Intervention Type: DRUG

Other Intervention Names

Prostate bed radiotherapy; Three-Dimensional Conformal Radiation Therapy (3D-CRT); Intensity modulated RT (IMRT); Pelvic lymph node radiotherapy; flutamide; bicalutamide; leuprolide; goserelin; buserelin; triptorelin

Eligibility Criteria

Inclusion Criteria

1. Adenocarcinoma of the prostate treated primarily with radical prostatectomy, pathologically proven to be lymph node negative by pelvic lymphadenectomy (N0) or lymph node status pathologically unknown (undissected pelvic lymph nodes [Nx]), i.e. lymph node dissection is not required;

• Any type of radical prostatectomy will be permitted, including retropubic, perineal, laparoscopic or robotically assisted. There is no time limit for the date of radical prostatectomy.

2. A post-radical prostatectomy entry prostate-specific antigen (PSA) of ≥ 0.1 and < 2.0 ng/mL at least 6 weeks (45 days) after prostatectomy and within 30 days of registration;

3. One of the following pathologic classifications:

• T3N0/Nx disease with or without a positive prostatectomy surgical margin; or
• T2N0/Nx disease with or without a positive prostatectomy surgical margin;

4. Prostatectomy Gleason score of 9 or less;

5. Zubrod Performance Status of 0-1;

6. Age ≥ 18;

7. No distant metastases, based upon the following minimum diagnostic workup:

• History/physical examination (including digital rectal exam) within 8 weeks (60 days) prior to registration;
• A computerized tomography (CT) scan of the pelvis (with contrast if renal function is acceptable; a noncontrast CT is permitted if the patient is not a candidate for contrast) or magnetic resonance imaging (MRI) of the pelvis within 120 days prior to registration;
• Bone scan within 120 days prior to registration; if the bone scan is suspicious, a plain x-ray and/or MRI must be obtained to rule out metastasis.

8. Adequate bone marrow function, within 90 days prior to registration, defined as follows:

• Platelets ≥ 100,000 cells/mm^3 based upon compete blood count (CBC);
• Hemoglobin ≥ 10.0 g/dl based upon CBC (Note: The use of transfusion or other intervention to achieve Hgb ≥ 10.0 g/dl is recommended).

9. Aspartate aminotransferase (AST) or alanine aminotransferase (ALT) < 2 x the upper limit of normal within 90 days prior to registration;

10. Serum total testosterone must be ≥ 40% of the lower limit of normal (LLN) of the assay used (testosterone ÷ LLN must be ≥ 0.40) within 90 days prior to registration (Note: Patients who have had a unilateral orchiectomy are eligible as long as this requirement is met);

11. Patients must sign a study-specific informed consent prior to study entry.

Exclusion Criteria

1. A palpable prostatic fossa abnormality/mass suggestive of recurrence, unless shown by biopsy under ultrasound guidance not to contain cancer;

2. N1 patients are ineligible, as are those with pelvic lymph node enlargement ≥ 1.5 cm in greatest dimension by CT scan or MRI of the pelvis, unless the enlarged lymph node is sampled and is negative;

3. Androgen deprivation therapy started prior to prostatectomy for > 6 months (180 days) duration. Note: The use of finasteride or dutasteride (±tamsulosin) for longer periods prior to prostatectomy is acceptable;

4. Androgen deprivation therapy started after prostatectomy and prior to registration (Note: The use of finasteride or dutasteride (±tamsulosin) after prostatectomy is not acceptable - must be stopped within 3 months after prostatectomy. Androgen deprivation therapy must be stopped within 3 months after prostatectomy);

5. Neoadjuvant chemotherapy before or after prostatectomy;

6. Prior chemotherapy for any other disease site if given within 5 years prior to registration;

7. Prior cryosurgery or brachytherapy of the prostate; prostatectomy should be the primary treatment and not a salvage procedure;

8. Prior pelvic radiotherapy;

9. Prior invasive malignancy (except non-melanomatous skin cancer) or superficial bladder cancer unless disease free for a minimum of 5 years [for example, carcinoma in situ of the oral cavity is permissible];

10. Severe, active co-morbidity, defined as follows:

• History of inflammatory bowel disease;
• History of hepatitis B or C; Blood tests are not required to determine if the patient has had hepatitis B or C, unless the patient reports a history of hepatitis.
• Unstable angina and/or congestive heart failure requiring hospitalization within the last 6 months;
• Transmural myocardial infarction within the last 6 months;
• Acute bacterial or fungal infection requiring intravenous antibiotics at the time of registration;
• Chronic Obstructive Pulmonary Disease exacerbation or other respiratory illness requiring hospitalization or precluding study therapy at the time of registration;
• Hepatic insufficiency resulting in clinical jaundice and/or coagulation defects; AST or ALT are required; note, however, that laboratory tests for coagulation parameters are not required for entry into this protocol.
• Acquired Immune Deficiency Syndrome (AIDS) based upon current Centers for Disease Control and Prevention (CDC) definition; Note, however, that human immunodeficiency viruses (HIV) testing is not required for entry into this protocol. The need to exclude patients with acquired immunodeficiency syndrome (AIDS) from this protocol is necessary because the treatments involved in this protocol may result in increased toxicity and immunosuppression.

11. Prior allergic reaction to the study drug(s) involved in this protocol.

• Minimum Eligible Age: 18 Years
• Eligible Sex: MALE
• Accepts Healthy Volunteers: No

Sponsors

National Cancer Institute (NCI)

NIH

Sponsor Role: collaborator

Cancer and Leukemia Group B

NETWORK

Sponsor Role: collaborator

NRG Oncology

OTHER

Sponsor Role: collaborator

Radiation Therapy Oncology Group

NETWORK

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Alan Pollack, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

University of Miami

Locations

UAB Comprehensive Cancer Center

Birmingham, Alabama, United States

Fairbanks Cancer Treatment Center at Fairbanks Memorial Hospital

Fairbanks, Alaska, United States

Arizona Center for Cancer Care - Peoria

Peoria, Arizona, United States

Arizona Oncology Services Foundation

Phoenix, Arizona, United States

Arizona Oncology - Tucson

Tucson, Arizona, United States

Auburn Radiation Oncology

Auburn, California, United States

Peninsula Medical Center

Burlingame, California, United States

Radiation Oncology Centers - Cameron Park

Cameron Park, California, United States

Mercy Cancer Center at Mercy San Juan Medical Center

Carmichael, California, United States

East Bay Radiation Oncology Center

Castro Valley, California, United States

Valley Medical Oncology Consultants - Castro Valley

Castro Valley, California, United States

Enloe Cancer Center at Enloe Medical Center

Chico, California, United States

Valley Medical Oncology

Fremont, California, United States

Washington Township Hospital

Fremont, California, United States

California Cancer Center - Woodward Park Office

Fresno, California, United States

Cancer Care Associates

Fresno, California, United States

Rebecca and John Moores UCSD Cancer Center

La Jolla, California, United States

Veterans Affairs Medical Center - Long Beach

Long Beach, California, United States

Samuel Oschin Comprehensive Cancer Institute at Cedars-Sinai Medical Center

Los Angeles, California, United States

USC/Norris Comprehensive Cancer Center and Hospital

Los Angeles, California, United States

Contra Costa Regional Medical Center

Martinez, California, United States

Providence Holy Cross Cancer Center

Mission Hills, California, United States

Memorial Medical Center

Modesto, California, United States

El Camino Hospital Cancer Center

Mountain View, California, United States

Sutter Health - Western Division Cancer Research Group

Novato, California, United States

Alta Bates Summit Medical Center - Summit Campus

Oakland, California, United States

Bay Area Breast Surgeons, Incorporated

Oakland, California, United States

CCOP - Bay Area Tumor Institute

Oakland, California, United States

Larry G Strieff MD Medical Corporation

Oakland, California, United States

Tom K Lee, Incorporated

Oakland, California, United States

St. Joseph Hospital Regional Cancer Center - Orange

Orange, California, United States

Feather River Hospital Cancer Center

Paradise, California, United States

Radiation Oncology Center - Roseville

Roseville, California, United States

Radiological Associates of Sacramento Medical Group, Incorporated

Sacramento, California, United States

University of California Davis Cancer Center

Sacramento, California, United States

Mercy General Hospital

Sacramento, California, United States

UCSF Helen Diller Family Comprehensive Cancer Center

San Francisco, California, United States

California Pacific Medical Center - California Campus

San Francisco, California, United States

Doctors Medical Center - San Pablo Campus

San Pablo, California, United States

Saint Helena Hospital

St. Helena, California, United States

Solano Radiation Oncology Center

Vacaville, California, United States

Sutter Solano Medical Center

Vallejo, California, United States

Aurora Presbyterian Hospital

Aurora, Colorado, United States

Rocky Mountain Cancer Centers - Aurora

Aurora, Colorado, United States

University of Colorado Cancer Center at UC Health Sciences Center

Aurora, Colorado, United States

Boulder Community Hospital

Boulder, Colorado, United States

St. Anthony Central Hospital

Denver, Colorado, United States

Porter Adventist Hospital

Denver, Colorado, United States

Presbyterian - St. Luke's Medical Center

Denver, Colorado, United States

St. Joseph Hospital

Denver, Colorado, United States

Swedish Medical Center

Englewood, Colorado, United States

North Colorado Medical Center

Greeley, Colorado, United States

Hope Cancer Care Center at Longmont United Hospital

Longmont, Colorado, United States

McKee Medical Center

Loveland, Colorado, United States

St. Mary - Corwin Regional Medical Center

Pueblo, Colorado, United States

North Suburban Medical Center

Thornton, Colorado, United States

Exempla Lutheran Medical Center

Wheat Ridge, Colorado, United States

Middlesex Hospital Cancer Center

Middletown, Connecticut, United States

George Bray Cancer Center at the Hospital of Central Connecticut - New Britain Campus

New Britain, Connecticut, United States

William W. Backus Hospital

Norwich, Connecticut, United States

CCOP - Christiana Care Health Services

Newark, Delaware, United States

Washington Cancer Institute at Washington Hospital Center

Washington D.C., District of Columbia, United States

University of Florida Shands Cancer Center

Gainesville, Florida, United States

Baptist Cancer Institute - Jacksonville

Jacksonville, Florida, United States

Integrated Community Oncology Network at Southside Cancer Center

Jacksonville, Florida, United States

Baptist Medical Center South

Jacksonville, Florida, United States

Integrated Community Oncology Network

Jacksonville Beach, Florida, United States

Baptist-South Miami Regional Cancer Program

Miami, Florida, United States

Integrated Community Oncology Network - Orange Park

Orange Park, Florida, United States

Florida Hospital Cancer Institute at Florida Hospital Orlando

Orlando, Florida, United States

Florida Cancer Center - Palatka

Palatka, Florida, United States

Flagler Cancer Center

Saint Augustine, Florida, United States

Veterans Affairs Medical Center - Tampa

Tampa, Florida, United States

Emory Crawford Long Hospital

Atlanta, Georgia, United States

Piedmont Hospital

Atlanta, Georgia, United States

Winship Cancer Institute of Emory University

Atlanta, Georgia, United States

Northside Hospital Cancer Center

Atlanta, Georgia, United States

John B. Amos Cancer Center

Columbus, Georgia, United States

Northside Hospital-Forsyth

Cumming, Georgia, United States

Piedmont Fayette Hospital

Fayetteville, Georgia, United States

Nancy N. and J. C. Lewis Cancer and Research Pavilion at St. Joseph's/Candler

Savannah, Georgia, United States

Cancer Research Center of Hawaii

Honolulu, Hawaii, United States

Queen's Cancer Institute at Queen's Medical Center

Honolulu, Hawaii, United States

Straub Clinic and Hospital, Incorporated

Honolulu, Hawaii, United States

Hawaii Medical Center - East

Honolulu, Hawaii, United States

Pacific Cancer Institute - Maui

Wailuku, Hawaii, United States

Kapiolani Medical Center at Pali Momi

‘Aiea, Hawaii, United States

Saint Alphonsus Cancer Care Center at Saint Alphonsus Regional Medical Center

Boise, Idaho, United States

Mount Sinai Hospital Medical Center

Chicago, Illinois, United States

Robert H. Lurie Comprehensive Cancer Center at Northwestern University

Chicago, Illinois, United States

University of Chicago Cancer Research Center

Chicago, Illinois, United States

Creticos Cancer Center at Advocate Illinois Masonic Medical Center

Chicago, Illinois, United States

Decatur Memorial Hospital Cancer Care Institute

Decatur, Illinois, United States

Leonard C. Ferguson Cancer Center

Freeport, Illinois, United States

Ingalls Cancer Care Center at Ingalls Memorial Hospital

Harvey, Illinois, United States

Veterans Affairs Medical Center - Hines

Hines, Illinois, United States

Cardinal Bernardin Cancer Center at Loyola University Medical Center

Maywood, Illinois, United States

Trinity Cancer Center at Trinity Medical Center - 7th Street Campus

Moline, Illinois, United States

Cancer Institute at St. John's Hospital

Springfield, Illinois, United States

Regional Cancer Center at Memorial Medical Center

Springfield, Illinois, United States

Elkhart General Hospital

Elkhart, Indiana, United States

Radiation Oncology Associates Southwest

Fort Wayne, Indiana, United States

Parkview Regional Cancer Center at Parkview Health

Fort Wayne, Indiana, United States

Center for Cancer Care at Goshen General Hospital

Goshen, Indiana, United States

Howard Community Hospital

Kokomo, Indiana, United States

Center for Cancer Therapy at LaPorte Hospital and Health Services

La Porte, Indiana, United States

Saint Joseph Regional Medical Center

Mishawaka, Indiana, United States

CCOP - Northern Indiana CR Consortium

South Bend, Indiana, United States

Memorial Hospital of South Bend

South Bend, Indiana, United States

CCOP - Iowa Oncology Research Association

Des Moines, Iowa, United States

John Stoddard Cancer Center at Iowa Methodist Medical Center

Des Moines, Iowa, United States

Medical Oncology and Hematology Associates at John Stoddard Cancer Center

Des Moines, Iowa, United States

Medical Oncology and Hematology Associates at Mercy Cancer Center

Des Moines, Iowa, United States

Mercy Cancer Center at Mercy Medical Center - Des Moines

Des Moines, Iowa, United States

John Stoddard Cancer Center at Iowa Lutheran Hospital

Des Moines, Iowa, United States

Siouxland Hematology-Oncology Associates, LLP

Sioux City, Iowa, United States

Mercy Medical Center - Sioux City

Sioux City, Iowa, United States

St. Luke's Regional Medical Center

Sioux City, Iowa, United States

Cancer Center of Kansas, PA - Dodge City

Dodge City, Kansas, United States

Cancer Center of Kansas, PA - El Dorado

El Dorado, Kansas, United States

Lawrence Memorial Hospital

Lawrence, Kansas, United States

Cancer Center of Kansas, PA - Wellington

Wellington, Kansas, United States

Associates in Womens Health, PA - North Review

Wichita, Kansas, United States

Cancer Center of Kansas, PA - Medical Arts Tower

Wichita, Kansas, United States

Cancer Center of Kansas, PA - Wichita

Wichita, Kansas, United States

CCOP - Wichita

Wichita, Kansas, United States

Via Christi Cancer Center at Via Christi Regional Medical Center

Wichita, Kansas, United States

Wesley Medical Center

Wichita, Kansas, United States

Cancer Center of Kansas, PA - Winfield

Winfield, Kansas, United States

Lucille P. Markey Cancer Center at University of Kentucky

Lexington, Kentucky, United States

Norton Suburban Hospital

Louisville, Kentucky, United States

Tulane Cancer Center Office of Clinical Research

Alexandria, Louisiana, United States

Mary Bird Perkins Cancer Center - Baton Rouge

Baton Rouge, Louisiana, United States

MBCCOP - LSU Health Sciences Center

New Orleans, Louisiana, United States

Medical Center of Louisiana - New Orleans

New Orleans, Louisiana, United States

CCOP - Ochsner

New Orleans, Louisiana, United States

Greenebaum Cancer Center at University of Maryland Medical Center

Baltimore, Maryland, United States

Greater Baltimore Medical Center Cancer Center

Baltimore, Maryland, United States

St. Agnes Hospital Cancer Center

Baltimore, Maryland, United States

Central Maryland Oncology Center

Columbia, Maryland, United States

Tate Cancer Center at Baltimore Washington Medical Center

Glen Burnie, Maryland, United States

Holy Cross Hospital

Silver Spring, Maryland, United States

Massachusetts General Hospital

Boston, Massachusetts, United States

Dana-Farber/Brigham and Women's Cancer Center

Boston, Massachusetts, United States

Dana-Farber/Harvard Cancer Center at Dana-Farber Cancer Institute

Boston, Massachusetts, United States

Boston University Cancer Research Center

Boston, Massachusetts, United States

Beth Israel Deaconess Medical Center

Boston, Massachusetts, United States

Hudner Oncology Center at Saint Anne's Hospital - Fall River

Fall River, Massachusetts, United States

Cape Cod Hospital

Hyannis, Massachusetts, United States

Lowell General Hospital

Lowell, Massachusetts, United States

Hickman Cancer Center at Bixby Medical Center

Adrian, Michigan, United States

Saint Joseph Mercy Cancer Center

Ann Arbor, Michigan, United States

CCOP - Michigan Cancer Research Consortium

Ann Arbor, Michigan, United States

University of Michigan Comprehensive Cancer Center

Ann Arbor, Michigan, United States

Henry Ford Macomb Hospital

Clinton Township, Michigan, United States

Oakwood Cancer Center at Oakwood Hospital and Medical Center

Dearborn, Michigan, United States

Josephine Ford Cancer Center at Henry Ford Hospital

Detroit, Michigan, United States

Genesys Hurley Cancer Institute

Flint, Michigan, United States

Hurley Medical Center

Flint, Michigan, United States

McLaren Cancer Institute

Flint, Michigan, United States

Van Elslander Cancer Center at St. John Hospital and Medical Center

Grosse Pointe Woods, Michigan, United States

Foote Memorial Hospital

Jackson, Michigan, United States

Borgess Medical Center

Kalamazoo, Michigan, United States

West Michigan Cancer Center

Kalamazoo, Michigan, United States

Bronson Methodist Hospital

Kalamazoo, Michigan, United States

Sparrow Regional Cancer Center

Lansing, Michigan, United States

St. Mary Mercy Hospital

Livonia, Michigan, United States

St. Joseph Mercy Oakland

Pontiac, Michigan, United States

Mercy Regional Cancer Center at Mercy Hospital

Port Huron, Michigan, United States

William Beaumont Hospital - Royal Oak Campus

Royal Oak, Michigan, United States

Seton Cancer Institute at Saint Mary's - Saginaw

Saginaw, Michigan, United States

Lakeland Regional Cancer Care Center - St. Joseph

Saint Joseph, Michigan, United States

St. John Macomb Hospital

Warren, Michigan, United States

MeritCare Bemidji

Bemidji, Minnesota, United States

Fairview Ridges Hospital

Burnsville, Minnesota, United States

Mercy and Unity Cancer Center at Mercy Hospital

Coon Rapids, Minnesota, United States

St. Luke's Hospital Cancer Care Center

Duluth, Minnesota, United States

Fairview Southdale Hospital

Edina, Minnesota, United States

Mercy and Unity Cancer Center at Unity Hospital

Fridley, Minnesota, United States

Immanuel St. Joseph's

Mankato, Minnesota, United States

HealthEast Cancer Care at St. John's Hospital

Maplewood, Minnesota, United States

Minnesota Oncology - Maplewood

Maplewood, Minnesota, United States

Virginia Piper Cancer Institute at Abbott - Northwestern Hospital

Minneapolis, Minnesota, United States

Hennepin County Medical Center - Minneapolis

Minneapolis, Minnesota, United States

Humphrey Cancer Center at North Memorial Outpatient Center

Robbinsdale, Minnesota, United States

Mayo Clinic Cancer Center

Rochester, Minnesota, United States

CCOP - Metro-Minnesota

Saint Louis Park, Minnesota, United States

Park Nicollet Cancer Center

Saint Louis Park, Minnesota, United States

Regions Hospital Cancer Care Center

Saint Paul, Minnesota, United States

United Hospital

Saint Paul, Minnesota, United States

St. Francis Cancer Center at St. Francis Medical Center

Shakopee, Minnesota, United States

Ridgeview Medical Center

Waconia, Minnesota, United States

Willmar Cancer Center at Rice Memorial Hospital

Willmar, Minnesota, United States

Minnesota Oncology - Woodbury

Woodbury, Minnesota, United States

Regional Cancer Center at Singing River Hospital

Pascagoula, Mississippi, United States

Cancer Institute of Cape Girardeau, LLC

Cape Girardeau, Missouri, United States

Siteman Cancer Center at Barnes-Jewish St. Peters Hospital - St. Peters

City of Saint Peters, Missouri, United States

Siteman Cancer Center at Barnes-Jewish Hospital - Saint Louis

St Louis, Missouri, United States

Barnes-Jewish West County Hospital

St Louis, Missouri, United States

CCOP - Montana Cancer Consortium

Billings, Montana, United States

Billings Clinic - Downtown

Billings, Montana, United States

Bozeman Deaconess Cancer Center

Bozeman, Montana, United States

Great Falls Clinic - Main Facility

Great Falls, Montana, United States

Sletten Cancer Institute at Benefis Healthcare

Great Falls, Montana, United States

Cancer Resource Center - Lincoln

Lincoln, Nebraska, United States

Saint Elizabeth Cancer Institute at Saint Elizabeth Regional Medical Center

Lincoln, Nebraska, United States

CCOP - Missouri Valley Cancer Consortium

Omaha, Nebraska, United States

Methodist Estabrook Cancer Center

Omaha, Nebraska, United States

Immanuel Medical Center

Omaha, Nebraska, United States

Alegant Health Cancer Center at Bergan Mercy Medical Center

Omaha, Nebraska, United States

Lakeside Hospital

Omaha, Nebraska, United States

Creighton University Medical Center

Omaha, Nebraska, United States

Nebraska Medical Center

Omaha, Nebraska, United States

CCOP - Nevada Cancer Research Foundation

Las Vegas, Nevada, United States

Center for Cancer Care at Exeter Hospital

Exeter, New Hampshire, United States

Kingsbury Center for Cancer Care at Cheshire Medical Center

Keene, New Hampshire, United States

Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center

Lebanon, New Hampshire, United States

Memorial Sloan-Kettering Cancer Center - Basking Ridge

Basking Ridge, New Jersey, United States

AtlantiCare Cancer Care Institute at AtlantiCare Regional Medical Center - Mainland Campus

Galloway, New Jersey, United States

Fox Chase Virtua Health Cancer Program at Virtua Memorial Hospital Marlton

Marlton, New Jersey, United States

Saint Peter's University Hospital

New Brunswick, New Jersey, United States

Cancer Institute of New Jersey at UMDNJ - Robert Wood Johnson Medical School

New Brunswick, New Jersey, United States

Capital Health Regional Cancer Center

Pennington, New Jersey, United States

Valley Hospital - Ridgewood

Ridgewood, New Jersey, United States

Somerset Medical Center

Somerville, New Jersey, United States

Frederick R. and Betty M. Smith Cancer Treatment Center

Sparta, New Jersey, United States

Franklin & Edith Scarpa Regional Cancer Center at South Jersey Healthcare

Vineland, New Jersey, United States

Cancer Institute of New Jersey at Cooper - Voorhees

Voorhees Township, New Jersey, United States

Fox Chase Virtua Health Cancer Program at Virtua West Jersey

Voorhees Township, New Jersey, United States

New Mexico Cancer Center

Albuquerque, New Mexico, United States

University of New Mexico Cancer Center

Albuquerque, New Mexico, United States

University of New Mexico Cancer Center - South

Las Cruces, New Mexico, United States

New York Oncology Hematology, PC at Albany Regional Cancer Care

Albany, New York, United States

New York Methodist Hospital

Brooklyn, New York, United States

Roswell Park Cancer Institute

Buffalo, New York, United States

Sands Cancer Center

Canandaigua, New York, United States

Memorial Sloan-Kettering Cancer Center

Commack, New York, United States

Stich Radiation Center at NewYork-Presbyterian Hospital/Weill Cornell Medical Center

New York, New York, United States

St. Luke's - Roosevelt Hospital Center - St.Luke's Division

New York, New York, United States

Dyson Center for Cancer Care at Vassar Brothers Medical Center

Poughkeepsie, New York, United States

Hudson Valley Oncology Associates

Poughkeepsie, New York, United States

Highland Hospital of Rochester

Rochester, New York, United States

Lipson Cancer and Blood Center at Rochester General Hospital

Rochester, New York, United States

University Radiation Oncology at Parkridge Hospital

Rochester, New York, United States

James P. Wilmot Cancer Center at University of Rochester Medical Center

Rochester, New York, United States

Memorial Sloan-Kettering Cancer Center - Rockville Centre

Rockville Centre, New York, United States

Memorial Sloan-Kettering Cancer Center at Phelps Memorial Hospital Center

Sleepy Hollow, New York, United States

Randolph Hospital

Asheboro, North Carolina, United States

Mission Hospitals - Memorial Campus

Asheville, North Carolina, United States

Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill

Chapel Hill, North Carolina, United States

Blumenthal Cancer Center at Carolinas Medical Center

Charlotte, North Carolina, United States

Moses Cone Regional Cancer Center at Wesley Long Community Hospital

Greensboro, North Carolina, United States

Coleman Radiation Oncology Center at Carter General Hospital

Morehead City, North Carolina, United States

CarolinaEast Cancer Care

New Bern, North Carolina, United States

FirstHealth Moore Regional Community Hospital Comprehensive Cancer Center

Pinehurst, North Carolina, United States

Rex Cancer Center at Rex Hospital

Raleigh, North Carolina, United States

Annie Penn Cancer Center

Reidsville, North Carolina, United States

South Atlantic Radiation Oncology, LLC

Supply, North Carolina, United States

Coastal Carolina Radiation Oncology Center

Wilmington, North Carolina, United States

Zimmer Cancer Center at New Hanover Regional Medical Center

Wilmington, North Carolina, United States

MeritCare Broadway

Fargo, North Dakota, United States

CCOP - MeritCare Hospital

Fargo, North Dakota, United States

Roger Maris Cancer Center at MeritCare Hospital

Fargo, North Dakota, United States

Altru Cancer Center at Altru Hospital

Grand Forks, North Dakota, United States

McDowell Cancer Center at Akron General Medical Center

Akron, Ohio, United States

Summa Center for Cancer Care at Akron City Hospital

Akron, Ohio, United States

Barberton Citizens Hospital

Barberton, Ohio, United States

Aultman Cancer Center at Aultman Hospital

Canton, Ohio, United States

Adena Regional Medical Center

Chillicothe, Ohio, United States

Case Comprehensive Cancer Center

Cleveland, Ohio, United States

Cleveland Clinic Cancer Center at Fairview Hospital

Cleveland, Ohio, United States

Cleveland Clinic Taussig Cancer Center

Cleveland, Ohio, United States

Arthur G. James Cancer Hospital and Richard J. Solove Research Institute at Ohio State University Comprehensive Cancer Center

Columbus, Ohio, United States

Riverside Methodist Hospital Cancer Care

Columbus, Ohio, United States

CCOP - Columbus

Columbus, Ohio, United States

Grant Medical Center Cancer Care

Columbus, Ohio, United States

Mount Carmel Health - West Hospital

Columbus, Ohio, United States

Doctors Hospital at Ohio Health

Columbus, Ohio, United States

Grady Memorial Hospital

Delaware, Ohio, United States

Community Cancer Center

Elyria, Ohio, United States

Hematology Oncology Center

Elyria, Ohio, United States

Cleveland Clinic Cancer Center

Independence, Ohio, United States

Lima Memorial Hospital

Lima, Ohio, United States

Strecker Cancer Center at Marietta Memorial Hospital

Marietta, Ohio, United States

Northwest Ohio Oncology Center

Maumee, Ohio, United States

Hillcrest Cancer Center at Hillcrest Hospital

Mayfield Heights, Ohio, United States

Lake/University Ireland Cancer Center

Mentor, Ohio, United States

Southwest General Health Center

Middleburg Heights, Ohio, United States

Licking Memorial Cancer Care Program at Licking Memorial Hospital

Newark, Ohio, United States

UHHS Chagrin Highlands Medical Center

Orange, Ohio, United States

St. Charles Mercy Hospital

Oregon, Ohio, United States

Parma Community General Hospital

Parma, Ohio, United States

Southern Ohio Medical Center Cancer Center

Portsmouth, Ohio, United States

Cancer Care Center, Incorporated

Salem, Ohio, United States

North Coast Cancer Care, Incorporated

Sandusky, Ohio, United States

Community Hospital of Springfield and Clark County

Springfield, Ohio, United States

Tony Teramana Cancer Center

Steubenville, Ohio, United States

Cleveland Clinic Foundation - Strongsville

Strongsville, Ohio, United States

Flower Hospital Cancer Center

Sylvania, Ohio, United States

Mercy Hospital of Tiffin

Tiffin, Ohio, United States

Toledo Hospital

Toledo, Ohio, United States

St. Vincent Mercy Medical Center

Toledo, Ohio, United States

Medical University of Ohio Cancer Center

Toledo, Ohio, United States

CCOP - Toledo Community Hospital

Toledo, Ohio, United States

St. Anne Mercy Hospital

Toledo, Ohio, United States

Toledo Clinic, Incorporated - Main Clinic

Toledo, Ohio, United States

Mount Carmel St. Ann's Cancer Center

Westerville, Ohio, United States

UHHS Westlake Medical Center

Westlake, Ohio, United States

Cancer Treatment Center

Wooster, Ohio, United States

Cleveland Clinic - Wooster

Wooster, Ohio, United States

Genesis - Good Samaritan Hospital

Zanesville, Ohio, United States

Oklahoma University Cancer Institute

Oklahoma City, Oklahoma, United States

Natalie Warren Bryant Cancer Center at St. Francis Hospital

Tulsa, Oklahoma, United States

Willamette Valley Cancer Center - Eugene

Eugene, Oregon, United States

Three Rivers Community Hospital

Grants Pass, Oregon, United States

Legacy Mount Hood Medical Center

Gresham, Oregon, United States

Dubs Cancer Center at Rogue Valley Medical Center

Medford, Oregon, United States

Providence Cancer Center at PMCC

Medford, Oregon, United States

Legacy Good Samaritan Hospital & Comprehensive Cancer Center

Portland, Oregon, United States

Salem Hospital Regional Cancer Care Services

Salem, Oregon, United States

Legacy Meridian Park Hospital

Tualatin, Oregon, United States

Rosenfeld Cancer Center at Abington Memorial Hospital

Abington, Pennsylvania, United States

UPMC Cancer Center at Beaver Medical Center

Beaver, Pennsylvania, United States

St. Luke's Cancer Network at St. Luke's Hospital

Bethlehem, Pennsylvania, United States

Bryn Mawr Hospital

Bryn Mawr, Pennsylvania, United States

UPMC Cancer Center at Jefferson Regional Medical Center

Clairton, Pennsylvania, United States

Geisinger Cancer Institute at Geisinger Health

Danville, Pennsylvania, United States

Northeast Radiation Oncology Center

Dunmore, Pennsylvania, United States

Adams Cancer Center

Gettysburg, Pennsylvania, United States

UPMC Cancer Center - Arnold Palmer Pavilion

Greensburg, Pennsylvania, United States

Penn State Hershey Cancer Institute at Milton S. Hershey Medical Center

Hershey, Pennsylvania, United States

UPMC Cancer Center at the John P. Murtha Pavilion

Johnstown, Pennsylvania, United States

Lancaster General Hospital

Lancaster, Pennsylvania, United States

St. Mary Regional Cancer Center

Langhorne, Pennsylvania, United States

UPMC Cancer Center at UPMC McKeesport

McKeesport, Pennsylvania, United States

Upper Delaware Valley Cancer Center

Milford, Pennsylvania, United States

Intercommunity Cancer Center

Monroeville, Pennsylvania, United States

UPMC - Moon

Moon Township, Pennsylvania, United States

Alle-Kiski Medical Center

Natrona Heights, Pennsylvania, United States

UPMC Cancer Center - Natrona Heights

Natrona Heights, Pennsylvania, United States

Jameson Memorial Hospital - North Campus

New Castle, Pennsylvania, United States

Cancer Center of Paoli Memorial Hospital

Paoli, Pennsylvania, United States

Kimmel Cancer Center at Thomas Jefferson University - Philadelphia

Philadelphia, Pennsylvania, United States

Fox Chase Cancer Center - Philadelphia

Philadelphia, Pennsylvania, United States

Albert Einstein Cancer Center

Philadelphia, Pennsylvania, United States

Allegheny Cancer Center at Allegheny General Hospital

Pittsburgh, Pennsylvania, United States

UPMC - Shadyside

Pittsburgh, Pennsylvania, United States

UPMC Cancer Center at Magee-Womens Hospital

Pittsburgh, Pennsylvania, United States

UPMC Cancer Center at UPMC Presbyterian

Pittsburgh, Pennsylvania, United States

UPMC Cancer Center at UPMC St. Margaret

Pittsburgh, Pennsylvania, United States

UPMC Cancer Center at UPMC Passavant

Pittsburgh, Pennsylvania, United States

UPMC Cancer Center - Upper St. Clair

Pittsburgh, Pennsylvania, United States

St. Joseph Medical Center

Reading, Pennsylvania, United States

McGlinn Family Regional Cancer Center at Reading Hospital and Medical Center

Reading, Pennsylvania, United States

Washington Hospital Cancer Center

Washington, Pennsylvania, United States

Frank M. and Dorothea Henry Cancer Center at Geisinger Wyoming Valley Medical Center

Wilkes-Barre, Pennsylvania, United States

CCOP - Main Line Health

Wynnewood, Pennsylvania, United States

Lankenau Cancer Center at Lankenau Hospital

Wynnewood, Pennsylvania, United States

York Cancer Center at Apple Hill Medical Center

York, Pennsylvania, United States

AnMed Cancer Center

Anderson, South Carolina, United States

Hollings Cancer Center at Medical University of South Carolina

Charleston, South Carolina, United States

Cancer Centers of the Carolinas - Faris Road

Greenville, South Carolina, United States

Cancer Centers of the Carolinas - Grove Commons

Greenville, South Carolina, United States

Cancer Centers of the Carolinas - Eastside

Greenville, South Carolina, United States

CCOP - Greenville

Greenville, South Carolina, United States

Cancer Centers of the Carolinas - Greer Medical Oncology

Greer, South Carolina, United States

Cancer Centers of the Carolinas - Greer Radiation Oncology

Greer, South Carolina, United States

Hilton Head Radiation Oncology Center

Hilton Head Island, South Carolina, United States

Cancer Centers of the Carolinas - Seneca

Seneca, South Carolina, United States

CCOP - Upstate Carolina

Spartanburg, South Carolina, United States

Gibbs Regional Cancer Center at Spartanburg Regional Medical Center

Spartanburg, South Carolina, United States

Cancer Centers of the Carolinas - Spartanburg

Spartanburg, South Carolina, United States

Rapid City Regional Hospital

Rapid City, South Dakota, United States

West Tennessee Cancer Center at Jackson-Madison County General Hospital

Jackson, Tennessee, United States

Texas Oncology, PA at Harris Center HEB

Bedford, Texas, United States

Simmons Comprehensive Cancer Center at University of Texas Southwestern Medical Center - Dallas

Dallas, Texas, United States

Texas Oncology, PA at Texas Cancer Center - Denton South

Denton, Texas, United States

Klabzuba Cancer Center at Harris Methodist Fort Worth Hospital

Fort Worth, Texas, United States

University of Texas Medical Branch

Galveston, Texas, United States

Memorial Hermann Hospital - Memorial City

Houston, Texas, United States

Texas Oncology, PA at Lake Vista Cancer Center

Lewisville, Texas, United States

Longview Cancer Center

Longview, Texas, United States

Cancer Care Centers of South Texas - Northeast

San Antonio, Texas, United States

Texas Oncology, PA at Texas Cancer Center - Sherman

Sherman, Texas, United States

Texas Oncology, PA at Texas Oncology Cancer Center Sugar Land

Sugar Land, Texas, United States

Tyler Cancer Center

Tyler, Texas, United States

Texas Oncology, PA - Wichita Falls

Wichita Falls, Texas, United States

Sandra L. Maxwell Cancer Center

Cedar City, Utah, United States

Logan Regional Hospital

Logan, Utah, United States

Jon and Karen Huntsman Cancer Center at Intermountain Medical Center

Murray, Utah, United States

Val and Ann Browning Cancer Center at McKay-Dee Hospital Center

Ogden, Utah, United States

Utah Valley Regional Medical Center - Provo

Provo, Utah, United States

Utah Cancer Specialists at UCS Cancer Center

Salt Lake City, Utah, United States

Huntsman Cancer Institute at University of Utah

Salt Lake City, Utah, United States

LDS Hospital

Salt Lake City, Utah, United States

Dixie Regional Medical Center - East Campus

St. George, Utah, United States

Fletcher Allen Health Care - University Health Center Campus

Burlington, Vermont, United States

Norris Cotton Cancer Center - North

Saint Johnsbury, Vermont, United States

INOVA Alexandria Hospital

Alexandria, Virginia, United States

Martha Jefferson Hospital Cancer Care Center

Charlottesville, Virginia, United States

Danville Regional Medical Center

Danville, Virginia, United States

Sentara Cancer Institute at Sentara Norfolk General Hospital

Norfolk, Virginia, United States

Naval Medical Center - Portsmouth

Portsmouth, Virginia, United States

Veterans Affairs Medical Center - Richmond

Richmond, Virginia, United States

Coastal Cancer Center at Sentara Virginia Beach General Hospital

Virginia Beach, Virginia, United States

St. Joseph Cancer Center

Bellingham, Washington, United States

St. Francis Hospital

Federal Way, Washington, United States

Good Samaritan Cancer Center

Puyallup, Washington, United States

CCOP - Virginia Mason Research Center

Seattle, Washington, United States

Virginia Mason Medical Center

Seattle, Washington, United States

Cancer Care Northwest - Spokane South

Spokane, Washington, United States

Franciscan Cancer Center at St. Joseph Medical Center

Tacoma, Washington, United States

CCOP - Northwest

Tacoma, Washington, United States

MultiCare Regional Cancer Center at Tacoma General Hospital

Tacoma, Washington, United States

Legacy Salmon Creek Medical Center

Vancouver, Washington, United States

North Star Lodge Cancer Center at Yakima Valley Memorial Hospital

Yakima, Washington, United States

West Virginia University Health Sciences Center - Charleston

Charleston, West Virginia, United States

Langlade Memorial Hospital

Antigo, Wisconsin, United States

Fox Valley Hematology and Oncology - East Grant Street

Appleton, Wisconsin, United States

Theda Care Cancer Institute

Appleton, Wisconsin, United States

Beloit Memorial Hospital

Beloit, Wisconsin, United States

Central Wisconsin Cancer Program at Agnesian HealthCare

Fond du Lac, Wisconsin, United States

Bellin Memorial Hospital

Green Bay, Wisconsin, United States

St. Vincent Hospital Regional Cancer Center

Green Bay, Wisconsin, United States

Franciscan Skemp Healthcare - La Crosse Campus

La Crosse, Wisconsin, United States

Gundersen Lutheran Center for Cancer and Blood

La Crosse, Wisconsin, United States

University of Wisconsin Paul P. Carbone Comprehensive Cancer Center

Madison, Wisconsin, United States

Bay Area Cancer Care Center at Bay Area Medical Center

Marinette, Wisconsin, United States

Community Memorial Hospital Cancer Care Center

Menomonee Falls, Wisconsin, United States

Columbia Saint Mary's Hospital - Ozaukee

Mequon, Wisconsin, United States

Columbia-Saint Mary's Water Tower Medical Commons

Milwaukee, Wisconsin, United States

Vince Lombardi Cancer Clinic at Aurora St. Luke's Medical Center

Milwaukee, Wisconsin, United States

Medical College of Wisconsin Cancer Center

Milwaukee, Wisconsin, United States

Veterans Affairs Medical Center - Milwaukee

Milwaukee, Wisconsin, United States

D.N. Greenwald Center

Mukwonago, Wisconsin, United States

Regional Cancer Center at Oconomowoc Memorial Hospital

Oconomowoc, Wisconsin, United States

All Saints Cancer Center at Wheaton Franciscan Healthcare

Racine, Wisconsin, United States

Door County Cancer Center at Door County Memorial Hospital

Sturgeon Bay, Wisconsin, United States

Aurora Medical Center

Summit, Wisconsin, United States

Waukesha Memorial Hospital Regional Cancer Center

Waukesha, Wisconsin, United States

University of Wisconcin Cancer Center at Aspirus Wausau Hospital

Wausau, Wisconsin, United States

West Allis Memorial Hospital

West Allis, Wisconsin, United States

Riverview UW Cancer Center at Riverview Hospital

Wisconsin Rapids, Wisconsin, United States

Rocky Mountain Oncology

Casper, Wyoming, United States

Tom Baker Cancer Centre - Calgary

Calgary, Alberta, Canada

Cross Cancer Institute at University of Alberta

Edmonton, Alberta, Canada

Saint John Regional Hospital

Saint John, New Brunswick, Canada

Doctor H. Bliss Murphy Cancer Centre

St. John's, Newfoundland and Labrador, Canada

Margaret and Charles Juravinski Cancer Centre

Hamilton, Ontario, Canada

London Regional Cancer Program at London Health Sciences Centre

London, Ontario, Canada

Cancer Care Program at Thunder Bay Regional Health Sciences

Thunder Bay, Ontario, Canada

Maisonneuve-Rosemont Hospital

Montreal, Quebec, Canada

Hopital Notre-Dame du CHUM

Montreal, Quebec, Canada

Centre Hospitalier Universitaire de Quebec

Québec, Quebec, Canada

CHUS-Hopital Fleurimont

Sherbrooke, Quebec, Canada

Allan Blair Cancer Centre at Pasqua Hospital

Regina, Saskatchewan, Canada

Saskatoon Cancer Centre at the University of Saskatchewan

Saskatoon, Saskatchewan, Canada

Pamela Youde Nethersole Eastern Hospital

Hong Kong, , China

Rabin Medical Center - Beilinson Campus

Petah Tikva, , Israel

Tel-Aviv Sourasky Medical Center

Tel Aviv, , Israel

Countries

United States; Canada; China; Israel

References

Pollack A, Karrison TG, Balogh AG, Gomella LG, Low DA, Bruner DW, Wefel JS, Martin AG, Michalski JM, Angyalfi SJ, Lukka H, Faria SL, Rodrigues GB, Beauchemin MC, Lee RJ, Seaward SA, Allen AM, Monitto DC, Seiferheld W, Sartor O, Feng F, Sandler HM. The addition of androgen deprivation therapy and pelvic lymph node treatment to prostate bed salvage radiotherapy (NRG Oncology/RTOG 0534 SPPORT): an international, multicentre, randomised phase 3 trial. Lancet. 2022 May 14;399(10338):1886-1901. doi: 10.1016/S0140-6736(21)01790-6.

Reference Type: DERIVED

PMID: 35569466 (View on PubMed)

Provided Documents

Document Type: Study Protocol and Statistical Analysis Plan

View Document

Document Type: Informed Consent Form

View Document

Study Documents

Document Type: Individual Participant Data Set

Select individual patient-level data from this trial can be requested from the NCTN/NCORP Data Archive

View Document

Other Identifiers

CDR0000577574

Identifier Type: -

Identifier Source: secondary_id

NCI-2009-00733

Identifier Type: REGISTRY

Identifier Source: secondary_id

RTOG-0534

Identifier Type: -

Identifier Source: org_study_id

NCT01312974

Identifier Type: -

Identifier Source: nct_alias