Androgen-Deprivation Therapy and Radiation Therapy in Treating Patients With Prostate Cancer
NCT ID: NCT01368588
Last Updated: 2025-10-28
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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ACTIVE_NOT_RECRUITING
PHASE3
2592 participants
INTERVENTIONAL
2011-07-31
2031-07-31
Brief Summary
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PURPOSE: This randomized phase III trial studies androgen-deprivation therapy and radiation therapy in treating patients with prostate cancer.
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Detailed Description
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Primary
* Demonstrate that prophylactic, neoadjuvant, androgen-deprivation therapy (NADT) and whole-pelvic radiation therapy (WPRT) will result in improvement in overall survival (OS) of patients with "unfavorable" intermediate-risk or "favorable" high-risk prostate cancer compared to NADT and high-dose prostate (P) and seminal vesicle (SV) radiation therapy (RT) using intensity-modulated RT (IMRT) or external-beam RT (EBRT) with a high-dose rate (HDR) or a permanent prostate (radioactive seed) implant (PPI) boost.
Secondary
* Demonstrate that prophylactic WPRT improves biochemical control.
* Determine the distant metastasis (DM)-free survival.
* Determine the cause-specific survival (CSS).
* Compare acute and late treatment-adverse events between patients receiving NADT and WPRT versus NADT, P, and SV RT.
* Determine whether health-related quality of life (HRQOL), as measured by the Expanded Prostate Cancer Index Composite (EPIC), significantly worsens with increasing aggressiveness of treatment (i.e., Arm 2, NADT + WPRT).
* Determine whether more aggressive treatment (Arm 2, NADT + WPRT) is associated with a greater increase in fatigue (PROMIS Fatigue Short Form) from baseline to last week of treatment, and a greater increase in circulating inflammatory markers (IL-1, IL-1ra, IL-6, tumor necrosis factor (TNF)-alpha, and C-reactive protein).
* Demonstrate an incremental gain in OS and CSS with more aggressive therapy that outweighs any detriments in the primary generic domains of HRQOL (i.e., mobility, self-care, usual activities, pain/discomfort, and anxiety/depression).
* Determine whether changes in fatigue from baseline to the next three time points (week prior to RT, last week of treatment, and 3 months after treatment) are associated with changes in circulating cytokines, mood, sleep, and daily activities across the same time points.
* Collect paraffin-embedded tissue blocks, plasma, whole blood, and urine for planned and future translational research analyses.
OUTLINE: This is a multicenter study. Patients are stratified according to moderate- to high-risk groups as listed in the Disease Characteristics of this abstract, type of radiotherapy boost (IMRT vs brachytherapy \[Low-dose rate (LDR) using PPI or HDR\]), and duration of androgen-deprivation therapy (short-term \[6 months\] vs long-term \[32 months\]). Patients are randomized to 1 of 2 treatment arms.
All patients receive neoadjuvant androgen-deprivation therapy comprising bicalutamide orally (PO) once daily or flutamide PO thrice daily for 6 months, and luteinizing hormone-releasing hormone (LHRH) agonist/antagonist therapy comprising leuprolide acetate, goserelin acetate, buserelin, triptorelin, or degarelix subcutaneously (SC) or intramuscularly (IM) every 1 to 3 months beginning 2 months prior to radiotherapy and continuing for 6 or 32 months.
Radiotherapy begins within 8 weeks after beginning LHRH agonist/antagonist injection.
* Arm I: Patients undergo high-dose radiotherapy of the prostate and seminal vesicles using intensity-modulated radiotherapy (IMRT)\* or 3D-conformal radiation therapy (3D-CRT)\* once daily, 5 days a week, for approximately 9 weeks. Patients may also undergo permanent prostate implant (PPI) brachytherapy or high-dose rate brachytherapy (iodine I 125 or palladium Pd 103 may be used as the radioisotope).
* Arm II: Patients undergo whole-pelvic radiotherapy (WPRT)\* (3D-CRT or IMRT) once daily, 5 days a week, for approximately 9 weeks. Patients may also undergo brachytherapy as in arm I.
NOTE: \* Patients undergoing brachytherapy implant receive 5 weeks of IMRT, 3D-CRT, or WPRT.
Patients may undergo blood and urine sample collection for correlative studies. Primary tumor tissue samples may also be collected.
Patients may complete the Expanded Prostate Cancer Index Composite (EPIC), the PROMIS-Fatigue Short Form, and the EuroQol (EQ-5D) quality-of-life (QOL) questionnaires at baseline and periodically during treatment. Patients who participate in the QOL portion of the study must also agree to periodic blood collection.
After completion of study therapy, patients are followed up every 3 months for 1 year, every 6 months for 3 years, and then yearly thereafter.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
NONE
Study Groups
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Arm I
Patients undergo high-dose radiotherapy of the prostate and seminal vesicles using intensity-modulated radiotherapy (IMRT)\* or 3D-conformal radiation therapy (3D-CRT)\* once daily, 5 days a week, for approximately 9 weeks. Patients may also undergo permanent prostate implant (PPI) brachytherapy or high-dose rate brachytherapy (I 125 or Pd 103 may be used as the radioisotope).
radiation therapy
Undergo RT using IMRT or 3D-CRT
Arm II
Patients undergo whole-pelvic radiotherapy (WPRT)\* (3D-CRT or IMRT) once daily, 5 days a week, for approximately 9 weeks. Patients may also undergo brachytherapy as in arm I.
Whole-pelvic radiotherapy (WPRT)
Undergo whole-pelvic radiotherapy (WPRT)
Interventions
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radiation therapy
Undergo RT using IMRT or 3D-CRT
Whole-pelvic radiotherapy (WPRT)
Undergo whole-pelvic radiotherapy (WPRT)
Eligibility Criteria
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Inclusion Criteria
* Clinically negative lymph nodes as established by imaging (pelvic and/or abdominal CT or MR), (but not by nodal sampling, or dissection) within 90 days prior to registration
* Patients with lymph nodes equivocal or questionable by imaging are eligible if the nodes are ≤ 1.5 cm
* Patients status post a negative lymph node dissection are not eligible
* No evidence of bone metastases (M0) on bone scan within 120 days prior to registration (Na F PET/CT is an acceptable substitute)
* Equivocal bone scan findings are allowed if plain films (or CT or MRI) are negative for metastasis
* Baseline serum PSA value performed with an FDA-approved assay (e.g., Abbott, Hybritech) within 120 days prior to registration
* Study entry PSA should not be obtained during the following time frames:
* Ten-day period following prostate biopsy
* Following initiation of hormonal therapy
* Within 30 days after discontinuation of finasteride
* Within 90 days after discontinuation of dutasteride
PATIENT CHARACTERISTICS:
* Zubrod performance status 0-1
* Absolute neutrophil count (ANC) ≥ 1,500/mm³
* Platelet count ≥ 100,000/mm³
* Hemoglobin (Hgb) ≥ 8.0 g/dL (transfusion or other intervention to achieve Hgb ≥ 8.0 g/dL is acceptable)
* No prior invasive (except non-melanoma skin cancer) malignancy unless disease-free for a minimum of 3 years (1,095 days) and not in the pelvis
* E.g., carcinoma in situ of the oral cavity is permissible; however, patients with prior history of bladder cancer are not allowed
* No prior hematological (e.g., leukemia, lymphoma, or myeloma) malignancy
* No previous radical surgery (prostatectomy) or cryosurgery for prostate cancer
* No previous pelvic irradiation, prostate brachytherapy or bilateral orchiectomy
* No previous hormonal therapy, such as LHRH agonists (e.g., leuprolide, goserelin, buserelin, triptorelin) or LHRH antagonist (e.g. degarelix), anti-androgens (e.g., flutamide, bicalutamide, cyproterone acetate), estrogens (e.g., DES), or surgical castration (orchiectomy)
* Prior pharmacologic androgen ablation for prostate cancer is allowed only if the onset of androgen ablation (both LHRH agonist and oral anti-androgen) is ≤ 45 days prior to the date of registration.
* No severe, active co-morbidity, defined as any of the following:
* Unstable angina and/or congestive heart failure requiring hospitalization within the last 6 months
* Transmural myocardial infarction within the last 6 months
* Acute bacterial or fungal infection requiring intravenous antibiotics at the time of registration
* Chronic obstructive pulmonary disease exacerbation or other respiratory illness requiring hospitalization or precluding study therapy at the time of registration
* Hepatic insufficiency resulting in clinical jaundice and/or coagulation defects or severe liver dysfunction
* Acquired immune deficiency syndrome (AIDS) based upon current Centers for Disease Control (CDC) definition
* Protocol-specific requirements may also exclude immuno-compromised patients
* HIV testing is not required for entry into this protocol
* No patients who are sexually active and not willing/able to use medically acceptable forms of contraception
* No prior allergic reaction to the hormones involved in this protocol
PRIOR CONCURRENT THERAPY:
* See Disease Characteristics
* No prior radical surgery (prostatectomy) or cryosurgery for prostate cancer
* No prior pelvic irradiation, prostate brachytherapy, or bilateral orchiectomy
* No prior hormonal therapy, such as luteinizing hormone-releasing hormone (LHRH) agonists (e.g., leuprolide, goserelin, buserelin, triptorelin) or LHRH antagonist (e.g., degarelix), anti-androgens (e.g., flutamide, bicalutamide, cyproterone acetate), estrogens (e.g., diethylstilbestrol (DES) ), or surgical castration (orchiectomy)
* No prior pharmacologic androgen ablation for prostate cancer unless the onset of androgen ablation is ≤ 45 days prior to the date of registration
* No finasteride within 30 days prior to registration
* No dutasteride or dutasteride/tamsulosin (Jalyn) within 90 days prior to registration
* No prior or concurrent cytotoxic chemotherapy for prostate cancer
* Prior chemotherapy for a different cancer is allowable
* No prior radiotherapy, including brachytherapy, to the region of the study cancer that would result in overlap of radiation therapy fields
18 Years
MALE
No
Sponsors
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National Cancer Institute (NCI)
NIH
NRG Oncology
OTHER
Radiation Therapy Oncology Group
NETWORK
Responsible Party
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Principal Investigators
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Mack Roach, MD
Role: PRINCIPAL_INVESTIGATOR
University of California, San Francisco
Locations
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University of South Alabama Mitchell Cancer Institute
Mobile, Alabama, United States
Anchorage Associates in Radiation Medicine
Anchorage, Alaska, United States
Alaska Oncology and Hematology LLC
Anchorage, Alaska, United States
Anchorage Oncology Centre
Anchorage, Alaska, United States
Katmai Oncology Group
Anchorage, Alaska, United States
Providence Alaska Medical Center
Anchorage, Alaska, United States
Fairbanks Memorial Hospital
Fairbanks, Alaska, United States
Arizona Breast Cancer Specialists-Gilbert
Gilbert, Arizona, United States
Arizona Center for Cancer Care-Peoria
Peoria, Arizona, United States
Cancer Center at Saint Joseph's
Phoenix, Arizona, United States
Saint Joseph's Hospital and Medical Center
Phoenix, Arizona, United States
Arizona Breast Cancer Specialists-Phoenix
Phoenix, Arizona, United States
Arizona Oncology-Deer Valley Center
Phoenix, Arizona, United States
21st Century Oncology-Scottsdale
Scottsdale, Arizona, United States
Arizona Breast Cancer Specialists
Scottsdale, Arizona, United States
Arizona Breast Cancer Specialists-Scottsdale
Scottsdale, Arizona, United States
Arizona Oncology Services Foundation
Scottsdale, Arizona, United States
Arizona Center for Cancer Care-Surprise
Surprise, Arizona, United States
Arizona Oncology Associates-West Orange Grove
Tucson, Arizona, United States
University of Arizona Cancer Center-Orange Grove Campus
Tucson, Arizona, United States
Banner University Medical Center - Tucson
Tucson, Arizona, United States
University of Arizona Cancer Center-North Campus
Tucson, Arizona, United States
CHI Saint Vincent Cancer Center Hot Springs
Hot Springs, Arkansas, United States
Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro
Jonesboro, Arkansas, United States
University of Arkansas for Medical Sciences
Little Rock, Arkansas, United States
Sutter Cancer Centers Radiation Oncology Services-Auburn
Auburn, California, United States
AIS Cancer Center at San Joaquin Community Hospital
Bakersfield, California, United States
Alta Bates Summit Medical Center-Herrick Campus
Berkeley, California, United States
Providence Saint Joseph Medical Center/Disney Family Cancer Center
Burbank, California, United States
Sutter Cancer Centers Radiation Oncology Services-Cameron Park
Cameron Park, California, United States
Mercy San Juan Medical Center
Carmichael, California, United States
Adventist Health Cancer Care Center Chico
Chico, California, United States
Fresno Cancer Center
Fresno, California, United States
Saint Agnes Medical Center
Fresno, California, United States
Marin General Hospital
Greenbrae, California, United States
UC San Diego Moores Cancer Center
La Jolla, California, United States
Tibor Rubin VA Medical Center
Long Beach, California, United States
Los Angeles County-USC Medical Center
Los Angeles, California, United States
USC / Norris Comprehensive Cancer Center
Los Angeles, California, United States
Cedars Sinai Medical Center
Los Angeles, California, United States
Fremont - Rideout Cancer Center
Marysville, California, United States
Mercy UC Davis Cancer Center
Merced, California, United States
Memorial Medical Center
Modesto, California, United States
Alta Bates Summit Medical Center - Summit Campus
Oakland, California, United States
Kaiser Permanente Oakland-Broadway
Oakland, California, United States
Desert Regional Medical Center
Palm Springs, California, United States
Palo Alto Medical Foundation Health Care
Palo Alto, California, United States
Stanford Cancer Institute Palo Alto
Palo Alto, California, United States
Pomona Valley Hospital Medical Center
Pomona, California, United States
Kaiser Permanente-Rancho Cordova Cancer Center
Rancho Cordova, California, United States
Rohnert Park Cancer Center
Rohnert Park, California, United States
Sutter Cancer Centers Radiation Oncology Services-Roseville
Roseville, California, United States
The Permanente Medical Group-Roseville Radiation Oncology
Roseville, California, United States
Mercy Cancer Center - Sacramento
Sacramento, California, United States
Sutter Medical Center Sacramento
Sacramento, California, United States
University of California Davis Comprehensive Cancer Center
Sacramento, California, United States
South Sacramento Cancer Center
Sacramento, California, United States
UCSF Medical Center-Mount Zion
San Francisco, California, United States
UCSF Medical Center-Mission Bay
San Francisco, California, United States
Santa Clara Valley Medical Center
San Jose, California, United States
Kaiser Permanente Medical Center - Santa Clara
Santa Clara, California, United States
Kaiser Permanente Cancer Treatment Center
South San Francisco, California, United States
Saint Joseph's Medical Center
Stockton, California, United States
Palo Alto Medical Foundation-Sunnyvale
Sunnyvale, California, United States
Gene Upshaw Memorial Tahoe Forest Cancer Center
Truckee, California, United States
Sutter Cancer Centers Radiation Oncology Services-Vacaville
Vacaville, California, United States
Rocky Mountain Cancer Centers-Aurora
Aurora, Colorado, United States
University of Colorado Hospital
Aurora, Colorado, United States
Rocky Mountain Cancer Centers-Boulder
Boulder, Colorado, United States
UCHealth Memorial Hospital Central
Colorado Springs, Colorado, United States
Porter Adventist Hospital
Denver, Colorado, United States
Shaw Cancer Center
Edwards, Colorado, United States
North Colorado Medical Center
Greeley, Colorado, United States
Longmont United Hospital
Longmont, Colorado, United States
McKee Medical Center
Loveland, Colorado, United States
Parker Adventist Hospital
Parker, Colorado, United States
Hartford HealthCare - Saint Vincent's Medical Center
Bridgeport, Connecticut, United States
Smilow Cancer Hospital Care Center at Saint Francis
Hartford, Connecticut, United States
Middlesex Hospital
Middletown, Connecticut, United States
Helen F Graham Cancer Center
Newark, Delaware, United States
Christiana Care Health System-Christiana Hospital
Newark, Delaware, United States
Beebe Health Campus
Rehoboth Beach, Delaware, United States
TidalHealth Nanticoke / Allen Cancer Center
Seaford, Delaware, United States
MedStar Washington Hospital Center
Washington D.C., District of Columbia, United States
Broward Health North
Deerfield Beach, Florida, United States
Baptist MD Anderson Cancer Center
Jacksonville, Florida, United States
Baptist Medical Center South
Jacksonville, Florida, United States
Jupiter Medical Center
Jupiter, Florida, United States
University of Miami Miller School of Medicine-Sylvester Cancer Center
Miami, Florida, United States
Orlando Health Cancer Institute
Orlando, Florida, United States
Cancer Center of Putnam
Palatka, Florida, United States
GenesisCare USA - Plantation
Plantation, Florida, United States
James A. Haley Veterans Affairs Hospital
Tampa, Florida, United States
Florida Cancer Affiliates
Trinity, Florida, United States
Cleveland Clinic-Weston
Weston, Florida, United States
Grady Health System
Atlanta, Georgia, United States
Emory University Hospital Midtown
Atlanta, Georgia, United States
Piedmont Hospital
Atlanta, Georgia, United States
Emory University Hospital/Winship Cancer Institute
Atlanta, Georgia, United States
Emory Saint Joseph's Hospital
Atlanta, Georgia, United States
John B Amos Cancer Center
Columbus, Georgia, United States
Atlanta VA Medical Center
Decatur, Georgia, United States
Piedmont Fayette Hospital
Fayetteville, Georgia, United States
Northeast Georgia Medical Center-Gainesville
Gainesville, Georgia, United States
Central Georgia Gynecologic Oncology
Macon, Georgia, United States
Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
Savannah, Georgia, United States
Queen's Medical Center
Honolulu, Hawaii, United States
The Cancer Center of Hawaii-Liliha
Honolulu, Hawaii, United States
The Cancer Center of Hawaii-Pali Momi
‘Aiea, Hawaii, United States
Saint Alphonsus Cancer Care Center-Boise
Boise, Idaho, United States
Kootenai Health - Coeur d'Alene
Coeur d'Alene, Idaho, United States
Idaho Urologic Institute-Meridian
Meridian, Idaho, United States
Kootenai Clinic Cancer Services - Post Falls
Post Falls, Idaho, United States
Kootenai Cancer Clinic
Sandpoint, Idaho, United States
Saint Luke's Cancer Institute - Twin Falls
Twin Falls, Idaho, United States
Northwest Community Hospital
Arlington Heights, Illinois, United States
Rush - Copley Medical Center
Aurora, Illinois, United States
John H Stroger Jr Hospital of Cook County
Chicago, Illinois, United States
Rush University Medical Center
Chicago, Illinois, United States
Weiss Memorial Hospital
Chicago, Illinois, United States
Advocate Illinois Masonic Medical Center
Chicago, Illinois, United States
UChicago Medicine Comprehensive Cancer Center - Saint Joseph Hospital
Chicago, Illinois, United States
Decatur Memorial Hospital
Decatur, Illinois, United States
Crossroads Cancer Center
Effingham, Illinois, United States
Loyola University Medical Center
Maywood, Illinois, United States
OSF Saint Francis Radiation Oncology at Peoria Cancer Center
Peoria, Illinois, United States
OSF Saint Francis Medical Center
Peoria, Illinois, United States
SwedishAmerican Regional Cancer Center/ACT
Rockford, Illinois, United States
Saint John's Hospital
Springfield, Illinois, United States
Memorial Medical Center
Springfield, Illinois, United States
Southwest Illinois Health Services LLP
Swansea, Illinois, United States
Carle Cancer Center
Urbana, Illinois, United States
Radiation Oncology Associates PC
Fort Wayne, Indiana, United States
Parkview Hospital Randallia
Fort Wayne, Indiana, United States
Parkview Regional Medical Center
Fort Wayne, Indiana, United States
Indiana University/Melvin and Bren Simon Cancer Center
Indianapolis, Indiana, United States
IU Health Methodist Hospital
Indianapolis, Indiana, United States
Memorial Hospital of South Bend
South Bend, Indiana, United States
McFarland Clinic PC - Ames
Ames, Iowa, United States
Saint Luke's Hospital
Cedar Rapids, Iowa, United States
Mercy Hospital
Cedar Rapids, Iowa, United States
Finley Hospital
Dubuque, Iowa, United States
Central Care Cancer Center - Garden City
Garden City, Kansas, United States
Saint Catherine Hospital
Garden City, Kansas, United States
University of Kansas Cancer Center
Kansas City, Kansas, United States
Lawrence Memorial Hospital
Lawrence, Kansas, United States
Olathe Health Cancer Center
Olathe, Kansas, United States
University of Kansas Cancer Center-Overland Park
Overland Park, Kansas, United States
Cotton O'Neil Cancer Center / Stormont Vail Health
Topeka, Kansas, United States
Ascension Via Christi Hospitals Wichita
Wichita, Kansas, United States
University of Kentucky/Markey Cancer Center
Lexington, Kentucky, United States
Owensboro Health Mitchell Memorial Cancer Center
Owensboro, Kentucky, United States
Mary Bird Perkins Cancer Center
Baton Rouge, Louisiana, United States
Mary Bird Perkins Cancer Center - Covington
Covington, Louisiana, United States
Mary Bird Perkins Cancer Center - Houma
Houma, Louisiana, United States
East Jefferson General Hospital
Metairie, Louisiana, United States
LSU Healthcare Network / Metairie Multi-Specialty Clinic
Metairie, Louisiana, United States
Tulane University Health Sciences Center
New Orleans, Louisiana, United States
Touro Infirmary
New Orleans, Louisiana, United States
Ochsner Medical Center Jefferson
New Orleans, Louisiana, United States
Anne Arundel Medical Center
Annapolis, Maryland, United States
University of Maryland/Greenebaum Cancer Center
Baltimore, Maryland, United States
Greater Baltimore Medical Center
Baltimore, Maryland, United States
Saint Agnes Hospital
Baltimore, Maryland, United States
UM Upper Chesapeake Medical Center
Bel Air, Maryland, United States
Central Maryland Radiation Oncology in Howard County
Columbia, Maryland, United States
University of Maryland Radiation Oncology Center at Union Hospital
Elkton, Maryland, United States
UM Baltimore Washington Medical Center/Tate Cancer Center
Glen Burnie, Maryland, United States
TidalHealth Peninsula Regional
Salisbury, Maryland, United States
UM Saint Joseph Medical Center
Towson, Maryland, United States
Massachusetts General Hospital Cancer Center
Boston, Massachusetts, United States
Saint Anne's Hospital
Fall River, Massachusetts, United States
Cape Cod Hospital
Hyannis, Massachusetts, United States
Lowell General Hospital
Lowell, Massachusetts, United States
Beth Israel Deaconess Hospital-Plymouth
Plymouth, Massachusetts, United States
Bixby Medical Center
Adrian, Michigan, United States
Veteran's Administration Medical Center - Ann Arbor
Ann Arbor, Michigan, United States
Saint Joseph Mercy Hospital
Ann Arbor, Michigan, United States
University of Michigan Comprehensive Cancer Center
Ann Arbor, Michigan, United States
Bronson Battle Creek
Battle Creek, Michigan, United States
McLaren Cancer Institute-Bay City
Bay City, Michigan, United States
Henry Ford Cancer Institute-Downriver
Brownstown, Michigan, United States
GenesisCare USA - Clarkston
Clarkston, Michigan, United States
McLaren Cancer Institute-Clarkston
Clarkston, Michigan, United States
Henry Ford Macomb Hospital-Clinton Township
Clinton Township, Michigan, United States
Beaumont Hospital - Dearborn
Dearborn, Michigan, United States
Wayne State University/Karmanos Cancer Institute
Detroit, Michigan, United States
Henry Ford Hospital
Detroit, Michigan, United States
Ascension Saint John Hospital
Detroit, Michigan, United States
GenesisCare USA - Farmington Hills
Farmington Hills, Michigan, United States
Weisberg Cancer Treatment Center
Farmington Hills, Michigan, United States
Beaumont Hospital - Farmington Hills
Farmington Hills, Michigan, United States
McLaren Cancer Institute-Flint
Flint, Michigan, United States
Mercy Health Saint Mary's
Grand Rapids, Michigan, United States
Spectrum Health at Butterworth Campus
Grand Rapids, Michigan, United States
West Michigan Cancer Center
Kalamazoo, Michigan, United States
Karmanos Cancer Institute at McLaren Greater Lansing
Lansing, Michigan, United States
Sparrow Hospital
Lansing, Michigan, United States
McLaren Cancer Institute-Lapeer Region
Lapeer, Michigan, United States
Saint Mary Mercy Hospital
Livonia, Michigan, United States
McLaren Cancer Institute-Macomb
Mount Clemens, Michigan, United States
McLaren Cancer Institute-Central Michigan
Mount Pleasant, Michigan, United States
Mercy Health Mercy Campus
Muskegon, Michigan, United States
McLaren Cancer Institute-Owosso
Owosso, Michigan, United States
McLaren Cancer Institute-Northern Michigan
Petoskey, Michigan, United States
21st Century Oncology-Pontiac
Pontiac, Michigan, United States
Saint Joseph Mercy Oakland
Pontiac, Michigan, United States
McLaren-Port Huron
Port Huron, Michigan, United States
William Beaumont Hospital-Royal Oak
Royal Oak, Michigan, United States
Ascension Saint Mary's Hospital
Saginaw, Michigan, United States
Lakeland Medical Center Saint Joseph
Saint Joseph, Michigan, United States
William Beaumont Hospital - Troy
Troy, Michigan, United States
GenesisCare USA - Troy
Troy, Michigan, United States
Saint John Macomb-Oakland Hospital
Warren, Michigan, United States
Henry Ford West Bloomfield Hospital
West Bloomfield, Michigan, United States
Metro Health Hospital
Wyoming, Michigan, United States
Mayo Clinic Health System in Albert Lea
Albert Lea, Minnesota, United States
Sanford Joe Lueken Cancer Center
Bemidji, Minnesota, United States
Saint Luke's Hospital of Duluth
Duluth, Minnesota, United States
Mayo Clinic Health Systems-Mankato
Mankato, Minnesota, United States
Hennepin County Medical Center
Minneapolis, Minnesota, United States
Monticello Cancer Center
Monticello, Minnesota, United States
Coborn Cancer Center at Saint Cloud Hospital
Saint Cloud, Minnesota, United States
Park Nicollet Clinic - Saint Louis Park
Saint Louis Park, Minnesota, United States
Regions Hospital
Saint Paul, Minnesota, United States
Rice Memorial Hospital
Willmar, Minnesota, United States
University of Mississippi Medical Center
Jackson, Mississippi, United States
Singing River Hospital
Pascagoula, Mississippi, United States
Saint Francis Medical Center
Cape Girardeau, Missouri, United States
Southeast Cancer Center
Cape Girardeau, Missouri, United States
Siteman Cancer Center at Saint Peters Hospital
City of Saint Peters, Missouri, United States
Siteman Cancer Center at West County Hospital
Creve Coeur, Missouri, United States
Freeman Health System
Joplin, Missouri, United States
North Kansas City Hospital
Kansas City, Missouri, United States
Kansas City Veterans Affairs Medical Center
Kansas City, Missouri, United States
The University of Kansas Cancer Center-South
Kansas City, Missouri, United States
University of Kansas Cancer Center - North
Kansas City, Missouri, United States
University of Kansas Cancer Center - Lee's Summit
Lee's Summit, Missouri, United States
Delbert Day Cancer Institute at PCRMC
Rolla, Missouri, United States
Heartland Regional Medical Center
Saint Joseph, Missouri, United States
CoxHealth South Hospital
Springfield, Missouri, United States
Washington University School of Medicine
St Louis, Missouri, United States
Veteran's Affairs Medical Center - Saint Louis
St Louis, Missouri, United States
Siteman Cancer Center-South County
St Louis, Missouri, United States
Missouri Baptist Medical Center
St Louis, Missouri, United States
Mercy Hospital Saint Louis
St Louis, Missouri, United States
Billings Clinic Cancer Center
Billings, Montana, United States
Benefis Healthcare- Sletten Cancer Institute
Great Falls, Montana, United States
Alegent Health Bergan Mercy Medical Center
Omaha, Nebraska, United States
University of Nebraska Medical Center
Omaha, Nebraska, United States
Renown Regional Medical Center
Reno, Nevada, United States
Exeter Hospital
Exeter, New Hampshire, United States
Dartmouth Hitchcock Medical Center
Lebanon, New Hampshire, United States
AtlantiCare Surgery Center
Egg Harbor, New Jersey, United States
Virtua Memorial
Mount Holly, New Jersey, United States
Inspira Medical Center Mullica Hill
Mullica Hill, New Jersey, United States
Penn Medicine Princeton Health
Plainsboro, New Jersey, United States
Sidney Kimmel Cancer Center Washington Township
Sewell, New Jersey, United States
Robert Wood Johnson University Hospital Somerset
Somerville, New Jersey, United States
Sparta Cancer Treatment Center
Sparta, New Jersey, United States
Inspira Medical Center Vineland
Vineland, New Jersey, United States
Virtua Voorhees
Voorhees Township, New Jersey, United States
Memorial Medical Center - Las Cruces
Las Cruces, New Mexico, United States
South Shore University Hospital
Bay Shore, New York, United States
New York-Presbyterian/Brooklyn Methodist Hospital
Brooklyn, New York, United States
Sands Cancer Center
Canandaigua, New York, United States
Mary Imogene Bassett Hospital
Cooperstown, New York, United States
Arnot Ogden Medical Center/Falck Cancer Center
Elmira, New York, United States
Northwell Health/Center for Advanced Medicine
Lake Success, New York, United States
Long Island Jewish Medical Center
New Hyde Park, New York, United States
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
New York, New York, United States
Wilmot Cancer Institute Radiation Oncology at Greece
Rochester, New York, United States
Highland Hospital
Rochester, New York, United States
University of Rochester
Rochester, New York, United States
Stony Brook University Medical Center
Stony Brook, New York, United States
James J Peters VA Medical Center
The Bronx, New York, United States
UNC Lineberger Comprehensive Cancer Center
Chapel Hill, North Carolina, United States
Durham VA Medical Center
Durham, North Carolina, United States
Duke University Medical Center
Durham, North Carolina, United States
The Coleman Radiation Center-Carteret General Hospital
Morehead City, North Carolina, United States
FirstHealth of the Carolinas-Moore Regional Hospital
Pinehurst, North Carolina, United States
UNC Rex Cancer Center
Raleigh, North Carolina, United States
NHRMC Radiation Oncology - Supply
Supply, North Carolina, United States
NHRMC Radiation Oncology - 16th Street
Wilmington, North Carolina, United States
Novant Health Forsyth Medical Center
Winston-Salem, North Carolina, United States
Wake Forest University Health Sciences
Winston-Salem, North Carolina, United States
Sanford Broadway Medical Center
Fargo, North Dakota, United States
Summa Health System - Akron Campus
Akron, Ohio, United States
Cleveland Clinic Akron General
Akron, Ohio, United States
Summa Health System - Barberton Campus
Barberton, Ohio, United States
UHHS-Chagrin Highlands Medical Center
Beachwood, Ohio, United States
Cleveland Clinic Mercy Hospital
Canton, Ohio, United States
Geauga Hospital
Chardon, Ohio, United States
Adena Regional Medical Center
Chillicothe, Ohio, United States
Case Western Reserve University
Cleveland, Ohio, United States
Cleveland Clinic Cancer Center/Fairview Hospital
Cleveland, Ohio, United States
Cleveland Clinic Foundation
Cleveland, Ohio, United States
Ohio State University Comprehensive Cancer Center
Columbus, Ohio, United States
The Mark H Zangmeister Center
Columbus, Ohio, United States
Mount Carmel Health Center West
Columbus, Ohio, United States
Mercy Cancer Center-Elyria
Elyria, Ohio, United States
Cleveland Clinic Cancer Center Independence
Independence, Ohio, United States
Cleveland Clinic Cancer Center Mansfield
Mansfield, Ohio, United States
Toledo Clinic Cancer Centers-Maumee
Maumee, Ohio, United States
Hillcrest Hospital Cancer Center
Mayfield Heights, Ohio, United States
Summa Health Medina Medical Center
Medina, Ohio, United States
UH Seidman Cancer Center at Lake Health Mentor Campus
Mentor, Ohio, United States
UH Seidman Cancer Center at Southwest General Hospital
Middleburg Heights, Ohio, United States
Saint Charles Hospital
Oregon, Ohio, United States
University Hospitals Parma Medical Center
Parma, Ohio, United States
Southern Ohio Medical Center
Portsmouth, Ohio, United States
University Hospitals Portage Medical Center
Ravenna, Ohio, United States
UH Seidman Cancer Center at Salem Regional Medical Center
Salem, Ohio, United States
North Coast Cancer Care
Sandusky, Ohio, United States
UH Seidman Cancer Center at Firelands Regional Medical Center
Sandusky, Ohio, United States
Cleveland Clinic Cancer Center Strongsville
Strongsville, Ohio, United States
ProMedica Flower Hospital
Sylvania, Ohio, United States
University of Toledo
Toledo, Ohio, United States
Mercy Health - Saint Anne Hospital
Toledo, Ohio, United States
UHHS-Westlake Medical Center
Westlake, Ohio, United States
Cancer Treatment Center
Wooster, Ohio, United States
Cleveland Clinic Wooster Family Health and Surgery Center
Wooster, Ohio, United States
Wright-Patterson Medical Center
Wright-Patterson Air Force Base, Ohio, United States
Genesis Healthcare System Cancer Care Center
Zanesville, Ohio, United States
University of Oklahoma Health Sciences Center
Oklahoma City, Oklahoma, United States
Saint John Medical Center
Tulsa, Oklahoma, United States
Clackamas Radiation Oncology Center
Clackamas, Oregon, United States
Three Rivers Community Hospital
Grants Pass, Oregon, United States
Providence Medford Medical Center
Medford, Oregon, United States
Rogue Valley Medical Center
Medford, Oregon, United States
Providence Portland Medical Center
Portland, Oregon, United States
Providence Saint Vincent Medical Center
Portland, Oregon, United States
Kaiser Permanente Northwest
Portland, Oregon, United States
Jefferson Abington Hospital
Abington, Pennsylvania, United States
Lehigh Valley Hospital-Cedar Crest
Allentown, Pennsylvania, United States
Geisinger Medical Center
Danville, Pennsylvania, United States
Northeast Radiation Oncology Center
Dunmore, Pennsylvania, United States
Ephrata Cancer Center
Ephrata, Pennsylvania, United States
Fox Chase Cancer Center Buckingham
Furlong, Pennsylvania, United States
Adams Cancer Center
Gettysburg, Pennsylvania, United States
Cherry Tree Cancer Center
Hanover, Pennsylvania, United States
Penn State Milton S Hershey Medical Center
Hershey, Pennsylvania, United States
Sechler Family Cancer Center
Lebanon, Pennsylvania, United States
Upper Delaware Valley Cancer Center
Milford, Pennsylvania, United States
Fox Chase Cancer Center
Philadelphia, Pennsylvania, United States
VA Pittsburgh Healthcare System
Pittsburgh, Pennsylvania, United States
Reading Hospital
West Reading, Pennsylvania, United States
Geisinger Wyoming Valley/Henry Cancer Center
Wilkes-Barre, Pennsylvania, United States
Asplundh Cancer Pavilion
Willow Grove, Pennsylvania, United States
WellSpan Health-York Hospital
York, Pennsylvania, United States
AnMed Health Cancer Center
Anderson, South Carolina, United States
Prisma Health Cancer Institute - Spartanburg
Boiling Springs, South Carolina, United States
Medical University of South Carolina
Charleston, South Carolina, United States
Tidelands Georgetown Memorial Hospital
Georgetown, South Carolina, United States
Prisma Health Cancer Institute - Faris
Greenville, South Carolina, United States
Saint Francis Cancer Center
Greenville, South Carolina, United States
Prisma Health Cancer Institute - Eastside
Greenville, South Carolina, United States
Self Regional Healthcare
Greenwood, South Carolina, United States
Prisma Health Cancer Institute - Greer
Greer, South Carolina, United States
Gibbs Cancer Center-Pelham
Greer, South Carolina, United States
The Radiation Oncology Center-Hilton Head/Bluffton
Hilton Head Island, South Carolina, United States
Prisma Health Cancer Institute - Seneca
Seneca, South Carolina, United States
Spartanburg Medical Center
Spartanburg, South Carolina, United States
Sanford USD Medical Center - Sioux Falls
Sioux Falls, South Dakota, United States
Erlanger Medical Center
Chattanooga, Tennessee, United States
Wellmont Holston Valley Hospital and Medical Center
Kingsport, Tennessee, United States
Vanderbilt University/Ingram Cancer Center
Nashville, Tennessee, United States
Texas Cancer Center
Abilene, Texas, United States
Texas Oncology PA Beaumont
Beaumont, Texas, United States
UT Southwestern/Simmons Cancer Center-Dallas
Dallas, Texas, United States
Texas Oncology - Denison Cancer Center
Denison, Texas, United States
Brooke Army Medical Center
Fort Sam Houston, Texas, United States
Texas Oncology - Fort Worth Cancer Center
Fort Worth, Texas, United States
University of Texas Medical Branch
Galveston, Texas, United States
Memorial Hermann Memorial City Medical Center
Houston, Texas, United States
Ben Taub General Hospital
Houston, Texas, United States
UTMB Cancer Center at Victory Lakes
League City, Texas, United States
Texas Oncology-McAllen
McAllen, Texas, United States
Texas Oncology-McKinney
McKinney, Texas, United States
West Texas Cancer Center
Odessa, Texas, United States
Texas Oncology-Plano West
Plano, Texas, United States
University of Texas Health Science Center at San Antonio
San Antonio, Texas, United States
Texas Oncology Cancer Center Sugar Land
Sugar Land, Texas, United States
Deke Slayton Cancer Center
Webster, Texas, United States
American Fork Hospital / Huntsman Intermountain Cancer Center
American Fork, Utah, United States
Sandra L Maxwell Cancer Center
Cedar City, Utah, United States
Intermountain Medical Center
Murray, Utah, United States
McKay-Dee Hospital Center
Ogden, Utah, United States
Ogden Regional Medical Center
Ogden, Utah, United States
Utah Valley Regional Medical Center
Provo, Utah, United States
Utah Cancer Specialists-Salt Lake City
Salt Lake City, Utah, United States
Huntsman Cancer Institute/University of Utah
Salt Lake City, Utah, United States
Dixie Medical Center Regional Cancer Center
St. George, Utah, United States
Southwestern Vermont Medical Center
Bennington, Vermont, United States
Central Vermont Medical Center/National Life Cancer Treatment
Berlin Corners, Vermont, United States
University of Vermont Medical Center
Burlington, Vermont, United States
Norris Cotton Cancer Center-North
Saint Johnsbury, Vermont, United States
University of Virginia Cancer Center
Charlottesville, Virginia, United States
Augusta Health Center for Cancer and Blood Disorders
Fishersville, Virginia, United States
Sentara Cancer Institute at Sentara CarePlex Hospital
Hampton, Virginia, United States
Sentara Rockingham Memorial Hospital Hahn Cancer Center
Harrisonburg, Virginia, United States
Bon Secours DePaul Medical Center
Norfolk, Virginia, United States
Sentara Norfolk General Hospital
Norfolk, Virginia, United States
Naval Medical Center - Portsmouth
Portsmouth, Virginia, United States
Hunter Holmes McGuire Veterans Administration Medical Center
Richmond, Virginia, United States
Oncology and Hematology Associates of Southwest Virginia
Roanoke, Virginia, United States
Sentara Obici Hospital
Suffolk, Virginia, United States
Sentara Virginia Beach General Hospital
Virginia Beach, Virginia, United States
Saint Francis Hospital
Federal Way, Washington, United States
Virginia Mason Medical Center
Seattle, Washington, United States
Madigan Army Medical Center
Tacoma, Washington, United States
PeaceHealth Southwest Medical Center
Vancouver, Washington, United States
North Star Lodge Cancer Center at Yakima Valley Memorial Hospital
Yakima, Washington, United States
United Hospital Center
Bridgeport, West Virginia, United States
West Virginia University Healthcare
Morgantown, West Virginia, United States
Langlade Hospital and Cancer Center
Antigo, Wisconsin, United States
ThedaCare Regional Cancer Center
Appleton, Wisconsin, United States
ThedaCare Regional Medical Center - Appleton
Appleton, Wisconsin, United States
Ascension Southeast Wisconsin Hospital - Elmbrook Campus
Brookfield, Wisconsin, United States
Marshfield Medical Center-EC Cancer Center
Eau Claire, Wisconsin, United States
Mayo Clinic Health System Eau Claire Hospital-Luther Campus
Eau Claire, Wisconsin, United States
Ascension Saint Francis - Reiman Cancer Center
Franklin, Wisconsin, United States
Saint Vincent Hospital Cancer Center Green Bay
Green Bay, Wisconsin, United States
Saint Vincent Hospital Cancer Center at Saint Mary's
Green Bay, Wisconsin, United States
Aurora BayCare Medical Center
Green Bay, Wisconsin, United States
UW Cancer Center Johnson Creek
Johnson Creek, Wisconsin, United States
Gundersen Lutheran Medical Center
La Crosse, Wisconsin, United States
Mayo Clinic Health System-Franciscan Healthcare
La Crosse, Wisconsin, United States
University of Wisconsin Hospital and Clinics
Madison, Wisconsin, United States
Aurora Bay Area Medical Group-Marinette
Marinette, Wisconsin, United States
Bay Area Medical Center
Marinette, Wisconsin, United States
Marshfield Medical Center-Marshfield
Marshfield, Wisconsin, United States
Froedtert Menomonee Falls Hospital
Menomonee Falls, Wisconsin, United States
Ascension Columbia Saint Mary's Hospital Ozaukee
Mequon, Wisconsin, United States
Ascension Southeast Wisconsin Hospital - Saint Joseph Campus
Milwaukee, Wisconsin, United States
Ascension Columbia Saint Mary's Hospital - Milwaukee
Milwaukee, Wisconsin, United States
Aurora Saint Luke's Medical Center
Milwaukee, Wisconsin, United States
Medical College of Wisconsin
Milwaukee, Wisconsin, United States
Zablocki Veterans Administration Medical Center
Milwaukee, Wisconsin, United States
Marshfield Clinic-Minocqua Center
Minocqua, Wisconsin, United States
Vince Lombardi Cancer Clinic - Oshkosh
Oshkosh, Wisconsin, United States
Ascension All Saints Hospital
Racine, Wisconsin, United States
Marshfield Medical Center-Rice Lake
Rice Lake, Wisconsin, United States
HSHS Saint Nicholas Hospital
Sheboygan, Wisconsin, United States
Vince Lombardi Cancer Clinic-Sheboygan
Sheboygan, Wisconsin, United States
Marshfield Clinic Stevens Point Center
Stevens Point, Wisconsin, United States
Saint Vincent Hospital Cancer Center at Sturgeon Bay
Sturgeon Bay, Wisconsin, United States
Aurora Medical Center in Summit
Summit, Wisconsin, United States
Vince Lombardi Cancer Clinic-Two Rivers
Two Rivers, Wisconsin, United States
Aspirus Regional Cancer Center
Wausau, Wisconsin, United States
Aurora West Allis Medical Center
West Allis, Wisconsin, United States
Froedtert West Bend Hospital/Kraemer Cancer Center
West Bend, Wisconsin, United States
Aspirus Cancer Care - Wisconsin Rapids
Wisconsin Rapids, Wisconsin, United States
Billings Clinic-Cody
Cody, Wyoming, United States
Tom Baker Cancer Centre
Calgary, Alberta, Canada
Cross Cancer Institute
Edmonton, Alberta, Canada
BCCA-Cancer Centre for the Southern Interior
Kelowna, British Columbia, Canada
BCCA-Fraser Valley Cancer Centre
Surrey, British Columbia, Canada
Doctor H. Bliss Murphy Cancer Centre
St. John's, Newfoundland and Labrador, Canada
QEII Health Sciences Centre/Nova Scotia Health Authority
Halifax, Nova Scotia, Canada
London Regional Cancer Program
London, Ontario, Canada
Stronach Regional Health Centre at Southlake
Newmarket, Ontario, Canada
Odette Cancer Centre- Sunnybrook Health Sciences Centre
Toronto, Ontario, Canada
CHUM - Hopital Notre-Dame
Montreal, Quebec, Canada
McGill University Department of Oncology
Montreal, Quebec, Canada
CHUM - Centre Hospitalier de l'Universite de Montreal
Montreal, Quebec, Canada
The Research Institute of the McGill University Health Centre (MUHC)
Montreal, Quebec, Canada
Jewish General Hospital
Montreal, Quebec, Canada
CHU de Quebec-L'Hotel-Dieu de Quebec (HDQ)
Québec, Quebec, Canada
Centre Hospitalier Universitaire de Sherbrooke-Fleurimont
Sherbrooke, Quebec, Canada
Allan Blair Cancer Centre
Regina, Saskatchewan, Canada
Saskatoon Cancer Centre
Saskatoon, Saskatchewan, Canada
Pamela Youde Nethersole Eastern Hospital
Chai Wan, , Hong Kong
Rabin Medical Center
Petah Tikva, , Israel
Chaim Sheba Medical Center
Tel Litwinsky, , Israel
National University Hospital Singapore
Singapore, , Singapore
National Cancer Centre Singapore
Singapore, , Singapore
Kantonsspital Aarau
Aarau, , Switzerland
Countries
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Other Identifiers
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CDR0000701128
Identifier Type: -
Identifier Source: secondary_id
NCI-2011-02674
Identifier Type: REGISTRY
Identifier Source: secondary_id
RTOG-0924
Identifier Type: -
Identifier Source: org_study_id
NCT02673190
Identifier Type: -
Identifier Source: nct_alias
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