Efficacy and Feasibility of a Personalized Treatment for Depression With Co-Occurring Anxiety

NCT ID: NCT00930293

Last Updated: 2016-02-09

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 50 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2009-07-31
• Study Completion Date: 2012-06-30

Brief Summary

This study will examine the feasibility and efficacy of a personalized psychotherapy treatment for people with depression and co-occurring anxiety.

Detailed Description

Approximately one half of all depressed psychiatric patients also meet the criteria for an anxiety disorder. Compared to people with only depression, people with both depression and panic features experience poorer psychological and social functioning, a greater risk of suicide, less response to medication and therapy treatment, and a greater risk of recurring symptoms. Because people with depression and co-occurring anxiety features do not achieve full symptom remission with either medication or therapy alone, this study will use a treatment that combines the two. A commonly used type of depression medication called a selective serotonin reuptake inhibitor (SSRI) will be combined with a specialized therapy developed to address depression with co-occurring symptoms of panic, anxiety, and avoidance. This study will also test a computer-based method of assessing mood and anxiety symptom profiles and outcomes to determine whether participants find this method acceptable and clinicians find it useful.

Participation in this study will last 20 weeks, with follow-up visits occurring 4 and 8 months after starting. Participants will be randomly assigned to receive either an individualized therapy for depression and anxiety, called interpersonal psychotherapy for depression with panic and anxiety symptoms (IPT-PS), or a standard therapy for depression, called brief supportive psychotherapy (BSP). All participants will complete up to 16 therapy sessions and receive a standard SSRI treatment with the medication citalopram hydrobromide. During the IPT-PS treatment, a study therapist will examine regular computer updates of depression and anxiety scores for participants and talk to them about identifying and addressing life stressors that trigger symptoms. During the BSP treatment, a study therapist will encourage participants to arrive at their own solutions by emphasizing the participants' strengths and examining what has worked in the past.

Participants will complete assessments weekly during the 20 weeks of the study intervention and at 4- and 8-month follow-up visits. These assessments will include self-report questionnaires about symptoms, medication side effects, and treatment adherence; vital sign and weight measurements; and a clinical interview. Regular assessments of medication effectiveness and side effects will occur every 1 to 4 weeks. Starting at the second study visit, participants will also complete monthly computer-based questionnaires about depression and anxiety symptoms.

Conditions

Depression; Anxiety

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Personalized Depression Care

Participants will receive interpersonal psychotherapy for depression with panic and anxiety symptoms (IPT-PS) and standard antidepressant medication (citalopram) treatment.

Group Type: EXPERIMENTAL

Interpersonal Psychotherapy for Depression with Panic and Anxiety Symptoms (IPT-PS)

Intervention Type: BEHAVIORAL

16 weekly IPT-PS sessions, each lasting approximately 45 minutes

Citalopram hydrobromide

Intervention Type: DRUG

A 20-week regimen of citalopram hydrobromide monotherapy on a flexible dosing schedule ranging from 10 to 60 mg/day

Standard Depression Care

Participants will receive brief supportive psychotherapy (BSP) and standard antidepressant medication (citalopram) treatment.

Group Type: ACTIVE_COMPARATOR

Brief Supportive Psychotherapy (BSP)

Intervention Type: BEHAVIORAL

16 weekly BPS sessions, each lasting approximately 45 minutes

Citalopram hydrobromide

Intervention Type: DRUG

A 20-week regimen of citalopram hydrobromide monotherapy on a flexible dosing schedule ranging from 10 to 60 mg/day

Interventions

Interpersonal Psychotherapy for Depression with Panic and Anxiety Symptoms (IPT-PS)

16 weekly IPT-PS sessions, each lasting approximately 45 minutes

Intervention Type: BEHAVIORAL

Brief Supportive Psychotherapy (BSP)

16 weekly BPS sessions, each lasting approximately 45 minutes

Intervention Type: BEHAVIORAL

Citalopram hydrobromide

A 20-week regimen of citalopram hydrobromide monotherapy on a flexible dosing schedule ranging from 10 to 60 mg/day

Intervention Type: DRUG

Other Intervention Names

Celexa

Eligibility Criteria

Inclusion Criteria

• Currently in an episode of nonpsychotic major depression, as defined by the DSM-IV and documented by both the Structured Clinical Interview for Axis I, DSM-IV Disorders (SCID) and by a rating of greater than 15 on the 25-item Hamilton Rating Scale for Depression (HRSD)
• Panic spectrum risk category of at least 7, as defined by the Panic-Agoraphobic Spectrum Self-Report (PAS-SR), last month version
• Not currently receiving effective treatment
• Participants with suicidal ideation are eligible as long as outpatient treatment is deemed safe.

Exclusion Criteria

• History of manic or hypomanic episode(s)
• History of schizophrenia or schizoaffective disorder
• Mood disorder due to a general medical condition or induced by substance use
• Presence of psychosis
• Current pregnancy or plans to become pregnant
• Current primary diagnosis of anorexia nervosa or bulimia nervosa (this does not include an eating disorder not otherwise specified [NOS])
• Current primary diagnosis of severe obsessive-compulsive disorder (OCD), as determined by clinician evaluation of symptom severity and temporal onset of symptoms
• Drug or alcohol abuse or dependence within the past 3 months (participants with episodic abuse related to mood episodes will not be excluded)
• Satisfies full DSM-IV criteria for antisocial personality disorder, as determined by SCID-II evaluation
• Requires inpatient treatment because of suicidal risk or psychotic symptoms (current suicidal thinking or parasuicidal behavior is not exclusionary if, in clinician judgment, it can be managed on an outpatient basis)
• Any of the following medical conditions:

1. An index episode that is secondary to the effect of medically prescribed drugs, i.e., reserpine, antihistamines, etc.

3. Current treatment with a pharmacologic, over-the-counter, or herbal therapy for depression or anxiety (unless the participant wishes to discontinue an ineffective treatment)

• History of poor or failed treatment response to an adequate dose and duration of citalopram

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 65 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

National Institute of Mental Health (NIMH)

NIH

Sponsor Role: collaborator

University of Pittsburgh

OTHER

Sponsor Role: lead

Responsible Party

Jill Cyranowski

Associate Professor of Psychiatry and Psychology

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Jill M. Cyranowski, PhD

Role: PRINCIPAL_INVESTIGATOR

University of Pittsburgh

Locations

Western Psychiatric Institute and Clinic

Pittsburgh, Pennsylvania, United States

Countries

United States

Other Identifiers

R01MH085874

Identifier Type: NIH

Identifier Source: secondary_id

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MH085874-01

Identifier Type: -

Identifier Source: secondary_id

PRO08070009

Identifier Type: -

Identifier Source: secondary_id

PCC: DSIR 84-CT

Identifier Type: -

Identifier Source: secondary_id

R01MH085874

Identifier Type: NIH

Identifier Source: org_study_id

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