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Brain-derived Neurotrophic Factor Participates in Visceral Hyperalgesia in Irritable Bowel Syndrome (IBS) Patients

NCT ID: NCT00925223

Last Updated: 2009-10-14

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

30 participants

Study Classification

OBSERVATIONAL

Study Start Date

2009-06-30

Study Completion Date

2009-11-30

Brief Summary

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Brain-derived neurotrophic factor (BDNF), originally known to be a member of the nerve growth factor family, has aroused attention as a modulator in visceral hyperalgesia recently. Visceral hypersensitivity is recognized as a clinical hallmark in IBS patients. So in this study, the investigators will focus on the role of BDNF in colonic hyperalgesia in IBS patients.

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Detailed Description

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Conditions

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Irritable Bowel Syndrome

Study Design

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Observational Model Type

CASE_CONTROL

Study Groups

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irritable bowel syndrome

patients with diarrhea-predominant IBS will be enrolled in this group.

No interventions assigned to this group

control group

patients with colon cancer or colon polyp will be enrolled as control group.

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Patients diagnosed with irritable bowel syndrome.

Exclusion Criteria

* Patients have similar clinical symptoms as IBS, yet there is morphologic changes in the intestine.
Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Shandong University

OTHER

Sponsor Role lead

Responsible Party

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Qilu hospital of Shandong University

Principal Investigators

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Yanqing Li, PhD. MD.

Role: STUDY_DIRECTOR

Department of Gastroenterology, Qilu Hospital, Shandong University

Other Identifiers

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NSFC30570831

Identifier Type: -

Identifier Source: secondary_id

2009SDU-QILU-G02

Identifier Type: -

Identifier Source: org_study_id

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