The Expression of the Ionotropic Glutamate Receptors in Colon of IBS

NCT ID: NCT02512146

Last Updated: 2015-07-30

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

80 participants

Study Classification

OBSERVATIONAL

Study Start Date

2015-06-30

Study Completion Date

2016-06-30

Brief Summary

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The study aims to determine the expression of the ionotropic glutamate receptors in colon of irritable bowel syndrome (IBS) patients and evaluate the relationship between the ionotropic glutamate receptors and IBS symptoms.

Detailed Description

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Ionotropic glutamate receptors participate in pain in nervous system. In this study,participants will examine the expression of the ionotropic glutamate receptors in colon of irritable bowel syndrome (IBS) patients and evaluate the relationship between the ionotropic glutamate receptors and IBS symptoms.

Participants may futher study the mechanism using cell experiment.

Conditions

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Irritable Bowel Syndrome

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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Irritable bowel syndrome

Patients meeting Rome III criteria of irritable bowel syndrome. Intervention: colonoscopy.

colonoscopy

Intervention Type PROCEDURE

Patients will undergo colonoscopy and participants will get biopsies from the colon.

Normal controls

Asymptomatic individuals for health surveillance or patients for follow up after polypectomy.

Intervention: colonoscopy.

colonoscopy

Intervention Type PROCEDURE

Patients will undergo colonoscopy and participants will get biopsies from the colon.

Interventions

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colonoscopy

Patients will undergo colonoscopy and participants will get biopsies from the colon.

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

Patients meeting IBS Rome III criteria. Asymptomatic individuals for health surveillance or patients for follow up after polypectomy.

Exclusion Criteria

Patients with known cancers or abdominal surgery. Alarm symptoms such as anaemia, gastrointestinal bleeding or obstruction, marked weight loss, abdominal mass. Patients who are unwilling to sign or give the informed consent form. Patients with impaired cardiac, liver or renal function. Patients with coagulopathy. Patients with pregnancy or breastfeeding.
Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Shandong University

OTHER

Sponsor Role lead

Responsible Party

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Yanqing Li

Vice president of Qilu Hospital

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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xiuli zuo, PHD

Role: STUDY_DIRECTOR

Department of Gastroenterology, Qilu Hospital

Locations

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Department of Gastroenterology, Qilu Hospital, Shandong University

Jinan, Shandong, China

Site Status RECRUITING

Countries

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China

Central Contacts

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xiuli zuo, PHD

Role: CONTACT

15588818685 ext. 0531-88369277

Facility Contacts

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xiuli zuo, PHD

Role: primary

15588818685 ext. 0531-88369277

Other Identifiers

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2015SDU-QILU-G03

Identifier Type: -

Identifier Source: org_study_id

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