Does APOE-e4 Predict Delirium and Cognitive Dysfunction After Surgery?

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

100 participants

Study Classification

OBSERVATIONAL

Study Start Date

2005-08-31

Study Completion Date

2009-05-31

Brief Summary

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Patients with the APOE-ε4 genotype are at increased risk of both vascular dementia and peripheral vascular disease. Patients undergoing major vascular surgery are at particularly high risk of delirium and other, more subtle, changes in cognitive function following surgery. The hypothesis of this trial is that the APOE-ε4 genotype is associated with both delirium and postoperative cognitive dysfunction (POCD).

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Detailed Description

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Conditions

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Delirium Postoperative Cognitive Dysfunction

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Open Aortic Repair

Patients 60 years of age and older undergoing open repair of the abdominal aorta

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Age 60 or greater
* Open repair of the abdominal aorta

Exclusion Criteria

* refusal;
* planned endovascular repair;
* emergency surgery;
* previous diagnosis of dementia, Parkinson's disease, or psychiatric illness;
* active alcohol or substance abuse; and
* physical inability to complete neuropsychometric testing.

Minimum Eligible Age

60 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No