Tissue Sample Collection From Patients With Soft Tissue Sarcoma of the Arms, Hands, Legs, or Feet Treated on Clinial Trial CRUK-VORTEX
NCT ID: NCT00900211
Last Updated: 2013-08-26
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
400 participants
OBSERVATIONAL
2007-08-31
Brief Summary
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PURPOSE: This laboratory is collecting tissue samples from patients with soft tissue sarcoma of the arms, hands, legs, or feet treated on clinical trial CRUK-VORTEX.
Detailed Description
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* Determine early in the course of treatment which patients treated on clinical trial CRUK-VORTEX have an increased likelihood of distant metastases so as to highlight individuals who might benefit from early adjuvant systemic therapy.
OUTLINE: This is a multicenter study.
Tumour and normal tissue samples will be taken at the time of surgery during treatment on clinical trial CRUK-VORTEXand preserved for future microarray analyses. Tissue microarrays will be produced from both tumor and normal tissues. Blood samples will be collected for future DNA analysis.
Conditions
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Keywords
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Interventions
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microarray analysis
molecular diagnostic method
biologic sample preservation procedure
Eligibility Criteria
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Inclusion Criteria
* Histologically confirmed soft tissue sarcoma
* Receiving treatment on clinical trial CRUK-VORTEX
* Underwent surgery to remove the tumor no more than 3 months ago
PATIENT CHARACTERISTICS:
* Not pregnant or nursing
* Negative pregnancy test
* Fertile patients must use effective contraception during and for 3 months after completion of study treatment
* No other major medical illness that would preclude study treatment
* No other prior or concurrent malignancy except adequately treated nonmelanoma carcinoma of the skin or in situ carcinoma of the cervix
PRIOR CONCURRENT THERAPY:
* No prior radiotherapy to the local site
* No prior neoadjuvant or adjuvant chemotherapy
16 Years
ALL
No
Sponsors
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The Christie NHS Foundation Trust
OTHER
Principal Investigators
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Catherine West
Role: STUDY_CHAIR
The Christie NHS Foundation Trust
Locations
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Queen Elizabeth Hospital at University Hospital of Birmingham NHS Trust
Birmingham, England, United Kingdom
Royal Orthopedic Hospital NHS Trust
Birmingham, England, United Kingdom
Bristol Haematology and Oncology Centre
Bristol, England, United Kingdom
Gloucestershire Oncology Centre at Cheltenham General Hospital
Cheltenham, England, United Kingdom
Royal National Orthopaedic Hospital NHS Trust
Cheltenham, England, United Kingdom
Middlesex Hospital
London, England, United Kingdom
Christie Hospital
Manchester, England, United Kingdom
Nottingham City Hospital
Nottingham, England, United Kingdom
Cancer Research Centre at Weston Park Hospital
Sheffield, England, United Kingdom
Robert Jones and Agnes Hunt Orthopaedic and District Hospital NHS Trust
Shropshire, England, United Kingdom
Beatson West of Scotland Cancer Centre
Glasgow, Scotland, United Kingdom
Glan Clwyd Hospital
Rhyl, Denbighshire, Wales, United Kingdom
Countries
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Facility Contacts
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Contact Person
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Other Identifiers
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VORTEX-SA3002
Identifier Type: -
Identifier Source: secondary_id
VORTEX-REC-06/MRE03/3
Identifier Type: -
Identifier Source: secondary_id
ISRCTN76456502
Identifier Type: -
Identifier Source: secondary_id
EU-20795
Identifier Type: -
Identifier Source: secondary_id
CDR0000581165
Identifier Type: -
Identifier Source: org_study_id