Studying Tumor Tissue Samples From Patients With Soft Tissue Sarcoma
NCT ID: NCT00900341
Last Updated: 2014-03-21
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
27 participants
OBSERVATIONAL
2005-08-31
2013-06-30
Brief Summary
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PURPOSE: This research study is looking at tumor tissue samples from patients with soft tissue sarcoma.
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Detailed Description
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* To develop a pilot program for the collection, archiving, and experimental analyses of soft tissue sarcomas (STS).
* To obtain STS tumors from cancer patients undergoing tumor removal or core needle biopsies.
* To evaluate cellular and molecular factors involved in STS oncogenesis by studying samples derived from human tumor specimens.
* To develop an accompanying bioinformatics database of the demographics of STS patients from which tumor specimens are derived for experimental study.
OUTLINE: Tumor tissue samples are analyzed for gene and protein expression by cDNA microarray analysis, RT-PCR, immunohistochemistry, in vitro transformation assays, RNA interference, and Western blot or immunoprecipitation.
Conditions
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Study Design
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CASE_ONLY
PROSPECTIVE
Interventions
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DNA analysis
gene expression analysis
protein expression analysis
reverse transcriptase-polymerase chain reaction
western blotting
immunohistochemistry staining method
laboratory biomarker analysis
Eligibility Criteria
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Inclusion Criteria
* Meets one of the following criteria:
* Patients with soft tissue sarcoma (STS) undergoing evaluation, treatment, and/or follow-up at the Arizona Cancer Center or University Medical Center
* Patients undergoing surgical treatment for STS removal or core needle biopsy for medically indicated diagnostic or therapeutic purposes
PATIENT CHARACTERISTICS:
* Not specified
PRIOR CONCURRENT THERAPY:
* Not specified
ALL
No
Sponsors
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National Cancer Institute (NCI)
NIH
University of Arizona
OTHER
Responsible Party
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Principal Investigators
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Lee D. Cranmer, MD, PhD
Role: PRINCIPAL_INVESTIGATOR
University of Arizona
Locations
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Arizona Cancer Center at University of Arizona Health Sciences Center
Tucson, Arizona, United States
Countries
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Other Identifiers
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UARIZ-HSCA0535
Identifier Type: OTHER
Identifier Source: secondary_id
UARIZ-17879
Identifier Type: -
Identifier Source: secondary_id
05-0509-04
Identifier Type: -
Identifier Source: org_study_id
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