Molecular Markers and Genetic Markers in Patients Undergoing Radiation Therapy for Cancer

NCT ID: NCT00899808

Last Updated: 2015-05-29

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

WITHDRAWN

Study Classification

OBSERVATIONAL

Study Start Date

2006-05-31

Brief Summary

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RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.

PURPOSE: This research study is looking at molecular markers and genetic markers in patients undergoing radiation therapy for cancer.

Detailed Description

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OBJECTIVES:

Primary

* Determine local-regional control in patients undergoing radiation therapy for cancer, as a function of expression of specific molecular/genetic markers.

Secondary

* Determine complications of radiation therapy for patients undergoing radiation therapy for cancer.

OUTLINE: Previously collected tissue samples are analyzed using immunohistochemical staining and other molecular/genetic study methods to detect markers, including p53, cyclin D1, HER-2-neu, bcl-2/BAX, and EGFR. Patient charts are also reviewed with emphasis on local-regional relapse.

Conditions

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Hematopoietic/Lymphoid Cancer Unspecified Adult Solid Tumor, Protocol Specific Unspecified Childhood Solid Tumor, Protocol Specific

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

RETROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

DISEASE CHARACTERISTICS:

* Diagnosis of cancer
* Undergoing radiation therapy for malignant disease

PATIENT CHARACTERISTICS:

* Not specified

PRIOR CONCURRENT THERAPY:

* See Disease Characteristics
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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National Cancer Institute (NCI)

NIH

Sponsor Role collaborator

Rutgers Cancer Institute of New Jersey

OTHER

Sponsor Role collaborator

Rutgers, The State University of New Jersey

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Bruce G. Haffty, MD

Role: PRINCIPAL_INVESTIGATOR

Rutgers Cancer Institute of New Jersey- Robert Wood Johnson Medical School

Locations

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Rutgers Cancer Institute of New Jersey - Robert Wood Johnson Medical School

New Brunswick, New Jersey, United States

Site Status

Countries

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United States

Other Identifiers

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P30CA072720

Identifier Type: NIH

Identifier Source: secondary_id

View Link

CDR0000592887

Identifier Type: -

Identifier Source: secondary_id

CINJ-IRB-0220060141

Identifier Type: -

Identifier Source: secondary_id

000609

Identifier Type: -

Identifier Source: org_study_id

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