Is Carotid Intima-media Thickness Affected by A1C Variability?

NCT ID: NCT00842972

Last Updated: 2009-09-15

Basic Information

• Recruitment Status: COMPLETED
• Study Classification: OBSERVATIONAL

Brief Summary

This study was conducted to evaluate the effect of A1C variability on the progression of carotid artery intima-media thickness in type 2 diabetic patients.

Conditions

Type 2 Diabetes; A1C Variability

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Eligibility Criteria

Inclusion Criteria

• type II
• fluoroscopy in carotid once a year during 2 years

Exclusion Criteria

• type 1 diabetes
• history or clinical evidence of coronary artery disease or cerebral or peripheral vascular disease
• the presence of albuminuria (defined as 24 hour urine albumin excretion ≥ 30 mg)
• renal dysfunction (defined as creatinine blood level ≥ 2.0 mg/dL)
• hepatic dysfunction (defined as alanine aminotransferase and/or aspartate aminotransferase blood level ≥ 3 × upper normal limit)
• smoking within the past 3 months prior to commencement of the study
• use of any medication likely to alter IMT such as calcium channel blocker, thiazolidinedione, antiplatelet agent (clopidogrel, cilostazol)
• use of glucocorticoid
• pregnancy
• severe concomitant disease such as cancer
• infection
• Cushing's syndrome
• acromegaly, or any other disorder likely to alter glycemia
• primary hypercholesterolemia
• hypothyroidism or hyperthyroidism
• use of any hormonal drugs
• alcoholism or drug abuse

• Minimum Eligible Age: 34 Years
• Maximum Eligible Age: 79 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Yonsei University

OTHER

Sponsor Role: lead

Responsible Party

Gangnam Severance Hospital

Other Identifiers

3-2006-0005

Identifier Type: -

Identifier Source: org_study_id