Glycosaminoglycans During Septic Shock - a Temporal Study

NCT ID: NCT00814112

Last Updated: 2024-03-15

Basic Information

• Recruitment Status: WITHDRAWN
• Study Classification: OBSERVATIONAL
• Study Start Date: 2008-11-30
• Study Completion Date: 2010-11-30

Brief Summary

We have previously shown that the plasma level of glycosaminoglycans (GAG) in septic shock patients are elevated compared to controls. The purpose of this study is to investigate the temporal dynamic of the blood level of GAG in ten septic shock patients. In addition, to assess the kinetics of GAG during septic shock we examine the liver function by galactose elimination capacity as well as excreted urinary GAG.

Conditions

Septic Shock

Study Design

• Observational Model Type: CASE_CONTROL
• Study Time Perspective: PROSPECTIVE

Study Groups

1 septic shock

septic shock, ICU

No interventions assigned to this group

2 controls

matched controls

No interventions assigned to this group

Eligibility Criteria

Inclusion Criteria

• 2 out of 4 SIRS criteria, where the circulatory criteria must be fulfilled
• Clinical sepsis is suspected
• Informed consent from relative
• Study subject must be over 18 years old

Exclusion Criteria

• Pregnancy
• >24h post sepsis diagnosis
• Ongoing oral or intravenous cortisone treatment for more than one month.
• Malignancy with metastasis

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 100 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Region Skane

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Mikael Bodelsson, professor

Role: PRINCIPAL_INVESTIGATOR

Intensive Care Unit, Lund University Hospital, Sweden

Locations

Intensive Care Unit, Lund University Hospital

Lund, , Sweden

Countries

Sweden

Other Identifiers

GAGS 293/2008

Identifier Type: -

Identifier Source: org_study_id