Loaded Breathing Training in Essential Hypertension

NCT ID: NCT00791986

Last Updated: 2018-03-07

Basic Information

• Recruitment Status: TERMINATED
• Clinical Phase: NA
• Total Enrollment: 30 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2006-05-31
• Study Completion Date: 2008-12-31

Brief Summary

The purpose of this study is to determine whether adding load to slow controlled breathing training could enhance blood pressure lowering in patients with essential hypertension.

Detailed Description

Hypertension (HT) is one of the major risk of cardiovascular diseases and cost of pharmacological treatment is a very high. Lifestyle modification is the first trial in stage 1 hypertension before commencing pharmacological treatment and a co-treatment with drug in hypertensive patient. Slow paced breathing training and physical training has been shown to reduce both systolic and diastolic blood pressure in HT. Moreover loaded breathing was reported to be able to decrease blood pressure in healthy. Loaded slow breathing training may enhance the antihypertensive effect of slow paced breathing.

Conditions

Essential Hypertension

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: FACTORIAL
• Primary Study Purpose: SUPPORTIVE_CARE
• Blinding Strategy: NONE

Study Groups

control

The patients in this control group do not conduct any breathing training.

Group Type: NO_INTERVENTION

No interventions assigned to this group

ULB

The patients conduct controlled slow breathing training using the WPTB device without inspiratory resistance.

Group Type: EXPERIMENTAL

ULB , LB

Intervention Type: DEVICE

ULB: The patients breath in slowly without resistance via the water pressure threshold breathing (WPTB) device, 30 min/day, 7 days/week for 8 weeks.

LB : The patients breath in slowly against resistance of 20 cmH2O provided by the water pressure threshold breathing (WPTB) device, 30 min/day, 7 days/week for 8 weeks.

LB

The patients breath in against resistance using WPTB device.

Group Type: EXPERIMENTAL

ULB , LB

Intervention Type: DEVICE

ULB: The patients breath in slowly without resistance via the water pressure threshold breathing (WPTB) device, 30 min/day, 7 days/week for 8 weeks.

LB : The patients breath in slowly against resistance of 20 cmH2O provided by the water pressure threshold breathing (WPTB) device, 30 min/day, 7 days/week for 8 weeks.

Interventions

ULB , LB

ULB: The patients breath in slowly without resistance via the water pressure threshold breathing (WPTB) device, 30 min/day, 7 days/week for 8 weeks.

LB : The patients breath in slowly against resistance of 20 cmH2O provided by the water pressure threshold breathing (WPTB) device, 30 min/day, 7 days/week for 8 weeks.

Intervention Type: DEVICE

Other Intervention Names

Guided breathing training; Paced breathing training; Controlled breathing training

Eligibility Criteria

Inclusion Criteria

• Clinical diagnosis of essential hypertension stage I-II

Exclusion Criteria

• Respiratory disease
• Diabetes mellitus
• Heart disease
• Renal disease
• Cerebrovascular disease
• Dyslipidemia
• Pregnancy

• Minimum Eligible Age: 35 Years
• Maximum Eligible Age: 65 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Thai health promotion foundation.

UNKNOWN

Sponsor Role: collaborator

Khon Kaen University

OTHER

Sponsor Role: lead

Responsible Party

Benjarat Sangthong

Faculty of associated medical science

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Chulee U Jones, Ph.D.

Role: STUDY_CHAIR

Department of Physical Therapy, Faculty of Associated Medical Sciences, Khon Kaen University.

Benjarat Sangthong, M.Sc.

Role: PRINCIPAL_INVESTIGATOR

Faculty of Physical Therapy, Rungsit University

Locations

Cardiopulmonary Physical Therapy Research Room, Faculty of Asociated Medical Sciences, Khon Kaen University.

Khon Kaen, , Thailand

Countries

Thailand

References

- Seals DR, Suwarno NO, Joyner MJ et al.Respiratory modulation of muscle sympathetic nerve activity in intact and lung denervated humans. Circulation Research 72(2): 440-454,1993. - Rosenthal T, Alter A, Peleg E, Gavish B. Device-guided breathing exercises reduce blood pressure: ambulatory and home measurements. Am J Hypertens 14(1):74-76,2001. - Viskoper R, Shapira I, Priluck R et al.Nonpharmacologic treatment of resistant hypertensive by device-guided slow breathing exercises. Am J Hypertens 16(6): 484-487,2003. - Grossman E, Grossman A, Schein MH et al.Breathing-control lowers blood pressure. J Hum Hypertens 15(4): 263-269,2001. - Viskoper R, Shapira I, Priluck R et al.Nonpharmacologic treatment of resistant hypertensive by device-guided slow breathing exercises. Am J Hypertens 16(6):484-487,2003 - Meles E, Giannattasio C, Failla M. et al.Non-pharmacologic treatment of hypertension by respiratory exercise in the home setting. Am J Hypertens 17(4):370-374,2004.

Reference Type: BACKGROUND

Other Identifiers

KKU-475090015-0

Identifier Type: -

Identifier Source: org_study_id