Study Results
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View full resultsBasic Information
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COMPLETED
PHASE1
200 participants
INTERVENTIONAL
2008-10-31
2013-11-30
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
DOUBLE
Study Groups
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Bupivacaine with Neostimgine 8 mcg/ml
STUDY DRUG INFUSION WITH NEOSTIGMINE 8 MCG/ML
Neostigmine
utilizing 3 different dosages of neostigmine and comparing it to the standard of fentanyl. Infusion runs via PCA throughout labor analgesia.
Bupivacaine
Bupivacaine and Neostigmine 4 mcg/ml
STUDY DRUG INFUSION CONC NEOSTIGMINE 4 MCG/ML
Neostigmine
utilizing 3 different dosages of neostigmine and comparing it to the standard of fentanyl. Infusion runs via PCA throughout labor analgesia.
Bupivacaine
Bupivacaine with Neostigmine 2 mcg/ml
STUDY DRUG INFUSION NEOSTIGMINE 2 MCG/ML
Neostigmine
utilizing 3 different dosages of neostigmine and comparing it to the standard of fentanyl. Infusion runs via PCA throughout labor analgesia.
Bupivacaine
BUPIVACAINE WITH FENTANYL 2 MCG/ML
Bupivacaine with fentanyl 2 mcg/ml. STANDARD INFUSION
Bupivacaine
fentanyl
fentanyl 2 mcg/ml
Interventions
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Neostigmine
utilizing 3 different dosages of neostigmine and comparing it to the standard of fentanyl. Infusion runs via PCA throughout labor analgesia.
Bupivacaine
fentanyl
fentanyl 2 mcg/ml
Eligibility Criteria
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Inclusion Criteria
* Term pregnancy ( \> 37 weeks)
* Primiparous or multiparous
* Induction or spontaneous labor greater or = 18 years of age
* Cervical exam on entry \</=5 cm
Exclusion Criteria
* Non-English speaking
* IV analgesics within 60 minutes prior to epidural being administered
* Allergy to local anesthetics or neostigmine
18 Years
50 Years
FEMALE
No
Sponsors
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Wake Forest University
OTHER
Responsible Party
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Principal Investigators
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Peter H Pan, MD
Role: PRINCIPAL_INVESTIGATOR
Wake Forest University Health Sciences OB Anesthesia
Locations
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Forsyth Medical Center
Winston-Salem, North Carolina, United States
Countries
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Other Identifiers
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IRB00005917
Identifier Type: -
Identifier Source: org_study_id
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