Validation of OxyVu for Assessing Level of Amputation With Comparison to Other Modalities

NCT ID: NCT00767923

Last Updated: 2009-06-04

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

20 participants

Study Classification

OBSERVATIONAL

Study Start Date

2008-07-31

Study Completion Date

2010-02-28

Brief Summary

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Correlation of(OxyVu) values to to ABI, TBP, and TCOM in patients scheduled for foot level amputation because of critical limb ischemia, infection, or tissue necrosis.

Detailed Description

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The purpose of this clinical study is to correlate tissue oxygenation values measured with a hyperspectral imaging system (OxyVu) to Ankle Brachial Indices (ABI), toe pressures (TBP), and transcutaneous oxygen monitoring (TCOM) in patients scheduled for foot level amputation because of critical limb ischemia, infection, or tissue necrosis.

Conditions

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Critical Limb Ischemia

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* 18 to 85 years of age, males and females, varying skin tones, varying racial origins, and with and without diabetes.
* Patients scheduled for foot level amputation because of critical limb ischemia, infection, or tissue necrosis.
Minimum Eligible Age

18 Years

Maximum Eligible Age

85 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Carl T. Hayden VA Medical Center

FED

Sponsor Role collaborator

HyperMed

INDUSTRY

Sponsor Role lead

Responsible Party

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HyperMed, Inc.

Principal Investigators

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Robert G Frykberg, DPM MPH

Role: PRINCIPAL_INVESTIGATOR

Carl T. Hayden VA Medical Center

Locations

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Carl T Hayden VA Medical Center

Phoenix, Arizona, United States

Site Status

Countries

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United States

References

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Second European Consensus Document on chronic critical leg ischemia. Eur J Vasc Surg. 1992 May;6 Suppl A:1-32. No abstract available.

Reference Type BACKGROUND
PMID: 1533191 (View on PubMed)

Deerochanawong C, Home PD, Alberti KG. A survey of lower limb amputation in diabetic patients. Diabet Med. 1992 Dec;9(10):942-6. doi: 10.1111/j.1464-5491.1992.tb01736.x.

Reference Type BACKGROUND
PMID: 1478041 (View on PubMed)

Frykberg RG. Guidelines for diabetic foot care. Foot Ankle Int. 2000 Jul;21(7):616. doi: 10.1177/107110070002100716. No abstract available.

Reference Type BACKGROUND
PMID: 10919631 (View on PubMed)

Ramsey SD, Newton K, Blough D, McCulloch DK, Sandhu N, Reiber GE, Wagner EH. Incidence, outcomes, and cost of foot ulcers in patients with diabetes. Diabetes Care. 1999 Mar;22(3):382-7. doi: 10.2337/diacare.22.3.382.

Reference Type BACKGROUND
PMID: 10097914 (View on PubMed)

Harrington C, Zagari MJ, Corea J, Klitenic J. A cost analysis of diabetic lower-extremity ulcers. Diabetes Care. 2000 Sep;23(9):1333-8. doi: 10.2337/diacare.23.9.1333.

Reference Type BACKGROUND
PMID: 10977028 (View on PubMed)

Greenman RL, Panasyuk S, Wang X, Lyons TE, Dinh T, Longoria L, Giurini JM, Freeman J, Khaodhiar L, Veves A. Early changes in the skin microcirculation and muscle metabolism of the diabetic foot. Lancet. 2005 Nov 12;366(9498):1711-7. doi: 10.1016/S0140-6736(05)67696-9.

Reference Type BACKGROUND
PMID: 16291064 (View on PubMed)

Zuzak KJ, Schaeberle MD, Gladwin MT, Cannon RO 3rd, Levin IW. Noninvasive determination of spatially resolved and time-resolved tissue perfusion in humans during nitric oxide inhibition and inhalation by use of a visible-reflectance hyperspectral imaging technique. Circulation. 2001 Dec 11;104(24):2905-10. doi: 10.1161/hc4901.100525.

Reference Type BACKGROUND
PMID: 11739304 (View on PubMed)

Khaodhiar L, Dinh T, Schomacker KT, Panasyuk SV, Freeman JE, Lew R, Vo T, Panasyuk AA, Lima C, Giurini JM, Lyons TE, Veves A. The use of medical hyperspectral technology to evaluate microcirculatory changes in diabetic foot ulcers and to predict clinical outcomes. Diabetes Care. 2007 Apr;30(4):903-10. doi: 10.2337/dc06-2209. Epub 2007 Feb 15.

Reference Type BACKGROUND
PMID: 17303790 (View on PubMed)

Benaron DA, Parachikov IH, Friedland S, Soetikno R, Brock-Utne J, van der Starre PJ, Nezhat C, Terris MK, Maxim PG, Carson JJ, Razavi MK, Gladstone HB, Fincher EF, Hsu CP, Clark FL, Cheong WF, Duckworth JL, Stevenson DK. Continuous, noninvasive, and localized microvascular tissue oximetry using visible light spectroscopy. Anesthesiology. 2004 Jun;100(6):1469-75. doi: 10.1097/00000542-200406000-00019.

Reference Type BACKGROUND
PMID: 15166566 (View on PubMed)

Related Links

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http://www.hypermed-inc.com

Sponsor and OxyVu technology website

Other Identifiers

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2008-011

Identifier Type: -

Identifier Source: org_study_id

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