Tissue Oxygen Use With Combined Arteriovenous Noninvasive Oximetry

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

20 participants

Study Classification

OBSERVATIONAL

Study Start Date

2024-01-11

Study Completion Date

2024-07-25

Brief Summary

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The goal of this observational study is to find out if researchers can measure oxygen consumption in the body without having to draw blood from lines in arteries and central veins.

Participants will undergo measurements of arterial blood oxygen saturation using both finger and neck pulse oximeters.

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Detailed Description

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TOUCAN-1 is a study to estimate the accuracy and precision of pulse oximetry as a noninvasive tool for oxygen consumption measurement. Researchers will use a pair of commercially-available, noninvasive pulse oximeters to estimate the oxygen saturation of blood in the internal jugular vein, and compare it to the directly measured oxygen saturation in sampled jugular blood. Researchers will then measure the arterial oxygen saturation in a finger, and compare it to the directly measured oxygen saturation in sampled radial arterial blood.

Conditions

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Oxygen Consumption

Study Design

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Observational Model Type

COHORT

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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Critically ill adults

Inpatient adults who require internal jugular venous central line and radial arterial line

Finger pulse oximetry probe

Intervention Type DEVICE

This finger probe will be used to make noninvasive measurements of systemic arterial and central venous oxygen saturations.

Transreflectance oximetry probe

Intervention Type DEVICE

This neck probe will be used to make noninvasive measurements of systemic arterial and central venous oxygen saturations.

Interventions

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Finger pulse oximetry probe

This finger probe will be used to make noninvasive measurements of systemic arterial and central venous oxygen saturations.

Intervention Type DEVICE

Transreflectance oximetry probe

This neck probe will be used to make noninvasive measurements of systemic arterial and central venous oxygen saturations.

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Inpatient at the University of Wisconsin University Hospital
* Has an internal jugular venous central line
* Has a radial arterial line

Exclusion Criteria

* Currently receiving extracorporeal membrane oxygenation (ECMO)
* Currently receiving continuous renal replacement therapy (CRRT/CVVH)
* All usable lumens of the participant's jugular catheter are in use, and interruption of any medical or therapy through any lumen would, in the view of the primary care team, compromise the participant's care.
* Jugular venous catheter is not functional or position is not confirmed by radiography
* Arterial cannula is not functional
* Known history of sickle cell anemia or other hemoglobinopathy
* Therapy with any of the following medications:

* Nitroprusside
* Hydroxocobalamin
* Indocyanine green
* Norepinephrine
* Vasopressin
* Epinephrine
* Any other medication or therapy that, in the judgement of the study investigators, may affect the accuracy and precision of the noninvasive oximetry results

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No