Septal Positioning of Ventricular Implanted Cardioverter Defibrillator (ICD) Leads

NCT ID: NCT00745745

Last Updated: 2019-02-04

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

299 participants

Study Classification

INTERVENTIONAL

Study Start Date

2008-08-31

Study Completion Date

2013-01-31

Brief Summary

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This clinical trial is a multi center, prospective, randomized, parallel study designed to compare septal to apical ICD lead placement.

Detailed Description

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The primary objective of this clinical investigation is to demonstrate that septal positioning of the right ventricular defibrillation lead is not inferior to the apical positioning in terms of safety and efficacy in a population of ICD recipients.

Conditions

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Ventricular Tachycardia Ventricular Fibrillation

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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1

Apical ICD lead placement

Group Type ACTIVE_COMPARATOR

Device Implantation

Intervention Type DEVICE

ICD lead implantation

2

Mid-Septal ICD lead placement

Group Type EXPERIMENTAL

Device Implantation

Intervention Type DEVICE

ICD lead implantation

Interventions

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Device Implantation

ICD lead implantation

Intervention Type DEVICE

Other Intervention Names

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CE marked ICD/CRT-D from St. Jude Medical and compatible CE marked ICD- and pacemaker- and active fixation ICD-leads

Eligibility Criteria

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Inclusion Criteria

* Age \>=18 years
* Signed written informed consent
* Approved indication for implantation of ICD / CRT-D device

Exclusion Criteria

* Preexisting transvenous RV pacemaker or ICD leads
* Pacemaker dependency without sufficient intrinsic rhythm (≤ 30min-1)
* Hypertrophic obstructive cardiomyopathy
* Presence of intra-aortic balloon pump
* Inotropic drug (not digitalis) necessary for hemodynamic support
* Inability to perform VF induction testing due to anticipated high risk
* Condition likely to limit cooperation
* Unable to give informed consent
* Pregnancy or planned pregnancy in the next 6 months
* Patients with planned cardiac surgery within the next 3 months following randomization
* Patient is currently participating in a clinical investigation that includes an active treatment arm.
* Acute myocardial infarction within the previous 4 weeks.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Abbott Medical Devices

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Christoph Kolb, MD

Role: PRINCIPAL_INVESTIGATOR

Deutsches Herzzentrum München des Freistaates Bayern

Locations

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Ost-Alb Klinikum

Aalen, , Germany

Site Status

SLK-Kliniken Heilbronn GmbH Klinikum am Plattenwald

Bad Friedrichshall, , Germany

Site Status

Segeberger Kliniken GmbH

Bad Segeberg, , Germany

Site Status

Städtisches Klinikum Brandenburg

Brandenburg, , Germany

Site Status

Medizinisches Versorgungszentrum

Dachau, , Germany

Site Status

Krankenhaus Düren gGmbH Akademisches Lehrkrankenhaus der RWTH-Aachen

Düren, , Germany

Site Status

Klinikum Esslingen

Esslingen am Neckar, , Germany

Site Status

Universitätsklinik Freiburg

Freiburg im Breisgau, , Germany

Site Status

Herzkatheterlabor der Kardiologischen Praxis am Krankenhaus Neu-Bethlehem gGmbH

Göttingen, , Germany

Site Status

Asklepios Klinik St. Georg

Hamburg, , Germany

Site Status

Oberhavel Kliniken GmbH Klinik Hennigsdorf

Hennigsdorf, , Germany

Site Status

Krankenhaus Landshut-Achdorf

Landshut, , Germany

Site Status

Universitätsklinikum Leipzig AÖR

Leipzig, , Germany

Site Status

Kliniken Ludwigsburg-Bietigheim

Ludwigsburg, , Germany

Site Status

Märkische Kliniken GmbH Klinikum Lüdenscheid

Lüdenscheid, , Germany

Site Status

Klinikum Mannheim gGmbH Fakultät für Klinische Medizin Mannheim der Universität Heidelberg

Mannheim, , Germany

Site Status

Maria-Hilf Franziskus-Krankenhaus

Mönchengladbach, , Germany

Site Status

Deutsches Herzzentrum Muenchen

Munich, , Germany

Site Status

Niels-Stensen-Kliniken Marienhospital Osnabrück

Osnabrück, , Germany

Site Status

Klinkum Peine gGmbH

Peine, , Germany

Site Status

Henry Dunant Hospital

Athens, , Greece

Site Status

Countries

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Germany Greece

References

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Kolb C, Solzbach U, Biermann J, Semmler V, Kloppe A, Klein N, Lennerz C, Szendey I, Andrikopoulos G, Tzeis S, Asbach S; SPICE-investigators. Safety of mid-septal electrode placement in implantable cardioverter defibrillator recipients--results of the SPICE (Septal Positioning of ventricular ICD Electrodes) study. Int J Cardiol. 2014 Jul 1;174(3):713-20. doi: 10.1016/j.ijcard.2014.04.229. Epub 2014 Apr 26.

Reference Type DERIVED
PMID: 24838056 (View on PubMed)

Other Identifiers

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T83

Identifier Type: -

Identifier Source: org_study_id

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