Beta-Blocker in Chronic Obstructive Pulmonary Disease (COPD) Study

NCT ID: NCT00745043

Last Updated: 2024-07-29

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

11 participants

Study Classification

INTERVENTIONAL

Study Start Date

2005-05-31

Study Completion Date

2007-08-31

Brief Summary

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Smoking causes both smoking related lung disease (COPD) and ischaemic heart disease. These are very common conditions and many patients have both diseases. Beta-blocker drugs are extensively used in the treatment of angina, high blood pressure and after heart attacks to decrease symptoms and prolong life. Beta-agonists are used in COPD to decrease breathlessness and improve exercise tolerance. It used to be thought that beta-blockers cannot be used in COPD patients as they may make the breathlessness worse, but it has now been established that they can be used safely. Beta-blocker drugs and beta-agonists have 'opposite' effects on the body and the investigators do not know if they can work together or if they would cancel each other out. The investigators also do not know which of the different types of beta-blockers now available are better for COPD patients. This study will investigate what happens to the airways of people taking both of these drugs.

Detailed Description

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Conditions

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Chronic Obstructive Pulmonary Disease

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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R302

Daily placebo capsules

Group Type PLACEBO_COMPARATOR

bronchodilator response

Intervention Type DRUG

R303

Daily metoprolol 95mg capsules

Group Type ACTIVE_COMPARATOR

bronchodilator response

Intervention Type DRUG

R304

Daily propranolol 80mg capsules

Group Type ACTIVE_COMPARATOR

bronchodilator response

Intervention Type DRUG

Open Label

Daily Metoprolol 190mg capsules

Group Type ACTIVE_COMPARATOR

bronchodilator response

Intervention Type DRUG

Interventions

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bronchodilator response

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Clinical diagnosis of COPD
* \> 40 years of age
* \> 15 pack year smoking history

Exclusion Criteria

* Contra-indication to beta-blocker use
* Severe COPD FEV1 \< 30% or 1 L
* Not responsive the methacholine
Minimum Eligible Age

40 Years

Maximum Eligible Age

100 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Waikato Hospital Research Fund

UNKNOWN

Sponsor Role collaborator

Waikato Hospital

OTHER

Sponsor Role lead

Responsible Party

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Respiratory Research Waikato Hospital

Principal Investigators

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Bob Hancox, MD FRACP

Role: STUDY_DIRECTOR

Waikato Hospital Research Unit

Locations

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Department of Respiratory Medicine

Hamilton, Waikato Region, New Zealand

Site Status

Countries

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New Zealand

Other Identifiers

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NTX/05/04/035

Identifier Type: -

Identifier Source: org_study_id

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