Impulsivity, Neural Deficits and Cocaine Addiction

NCT ID: NCT00744601

Last Updated: 2013-01-03

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 90 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2007-04-30
• Study Completion Date: 2012-09-30

Brief Summary

The purpose of this study is to assess neurocognitive and associated neural regions/circuitry disruptions relevant to impulsive relapse in cocaine-addicted subjects, and the relationship of the cognitive and neural mechanisms of impulsivity/decision-making to relapse style.

Detailed Description

This study is designed to explore putative differences in impulsive behaviors and decision making in cocaine-addicted and healthy control subjects using functional magnetic resonance imaging (fMRI), single photon emission tomography (SPECT), and neurocognitive tasks. We predict that cocaine-addicted subjects will demonstrate neurocognitive and neural alterations in measures of impulsivity and decision-making when compared to healthy controls. That is, cocaine-addicted subjects will show both decreased activation and decreased resting measures of regional cerebral blood flow (rCBF) of the brain structures associated with impulsivity and decision-making. Furthermore, neurocognitive and neural deficits associated with impulsivity and decision-making will be associated with each other and with measures indicative of an impulsive relapse and altered decision making.

Conditions

Cocaine Dependence

Study Design

• Observational Model Type: CASE_CONTROL
• Study Time Perspective: CROSS_SECTIONAL

Study Groups

1

Patients with Cocaine Addiction

No interventions assigned to this group

2

Healthy Control Volunteers

No interventions assigned to this group

Eligibility Criteria

Inclusion Criteria

• Cocaine-dependence (patient population) or no cocaine-dependence (control population).

Exclusion Criteria

• Other medical or psychiatric disorders that may effect neural functioning.
• Medications that may effect neural functioning.

• Minimum Eligible Age: 21 Years
• Maximum Eligible Age: 55 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

National Institute on Drug Abuse (NIDA)

NIH

Sponsor Role: collaborator

Dallas VA Medical Center

FED

Sponsor Role: collaborator

University of Texas Southwestern Medical Center

OTHER

Sponsor Role: lead

Responsible Party

Bryon H Adinoff

Professor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Bryon Adinoff, MD

Role: PRINCIPAL_INVESTIGATOR

UT Southwestern Medical Center at Dallas

Locations

UT Southwestern Medical Center at Dallas, Divison on Addictions

Dallas, Texas, United States

Countries

United States

Other Identifiers

1R01DA023203-01

Identifier Type: NIH

Identifier Source: secondary_id

View Link

DA023203

Identifier Type: -

Identifier Source: org_study_id