Serotonin, Impulsivity, and Cocaine Dependence Treatment

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE2

Total Enrollment

120 participants

Study Classification

INTERVENTIONAL

Study Start Date

2001-04-30

Study Completion Date

2004-11-30

Brief Summary

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The purpose of this study is to compare the effects of citalopram versus placebo given in the context of contingency management for cocaine dependence.

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Detailed Description

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Cocaine dependence continues to be a significant public health problem, for which there is no FDA approved pharmacotherapy. This study is a 12-week, double blind, placebo controlled trial of citalopram for cocaine dependence. The primary outcome measure is benzoylecgonine positive urines. Secondary measures of side effects and craving are also examined.

Conditions

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Cocaine Dependence

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Interventions

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citalopram

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* male and female subjects age 18 to 50 who currently meet DSM-IV criteria for cocaine dependence.
* female subjects: a negative pregnancy test

Exclusion Criteria

* current or past DSM-IV Axis I disorder other than substance abuse/dependence
* any serious non-psychiatric medical illness requiring ongoing medical treatment
* substance dependence other than cocaine within the last 3 months
* negative urine drug screen for cocaine at time of testing
* for female subjects: a positive pregnancy test

Minimum Eligible Age

18 Years

Maximum Eligible Age

50 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No