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Corrected Measurement of the Retinal Nerve Fiber Layer Thickness by Optic Disc Configuration With the Cirrus HD OCT

NCT ID: NCT00741130

Last Updated: 2008-08-26

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

50 participants

Study Classification

OBSERVATIONAL

Study Start Date

2008-07-31

Study Completion Date

2009-01-31

Brief Summary

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Because the measurement of the retinal nerve fiber layer thickness is very sensitive to the position of measurement, it may be incorrect in patients with the tilted disc. In the present study, the corrected RNFL thickness by the optic nerve head configuration using the Cirrus HD OCT will be evaluated. If the corrected RNFL thickness is more sensitive to detect the localized RNFL defect, the present software should be upgrade to reflect the optic nerve head configuration.

Detailed Description

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Finding the localized retinal nerve fiber layer (RNFL) defect and measuring the RNFL thickness are two main issues for early glaucoma detection. A recently developed imaging device, the Cirrus HD OCT, offers more detailed informations about retina architecture including optic nerve head. To calculate the RNFL thickness, the software of the Cirrus HD OCT supposes an ideal optic nerve head. However, in the cases with not ideal optic disc configuration, the measurement of the RNFL thickness is not correct. Because the measurement of the RNFL thickness is extremely sensitive to the position of measurement, patients with the tilted disc are in danger of misdiagnosis. In the present study, we want to correct the RNFL thickness measurement according to the optic nerve head configuration using the Cirrus HD OCT. If the corrected RNFL thickness is more sensitive to detect the localized RNFL defect, the present software should be upgrade to reflect the optic nerve head configuration.

Conditions

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Glaucoma Myopia

Keywords

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retinal nerve fiber layer optic nerve head Cirrus OCT

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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C

normal volunteers

No interventions assigned to this group

G

glaucoma patients

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* normal controls or glaucoma patients
* signal intensity of the OCT image \> 8
* cooperative subjects

Exclusion Criteria

* spherical equivalent refractive errors \> +4 diopters or \< -4 diopters
* significant media opacity
* previous intraocular surgery
Minimum Eligible Age

18 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Yonsei University

OTHER

Sponsor Role lead

Responsible Party

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Yonsei University College of Medicine

Principal Investigators

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Gong Je Seong, MD, PhD

Role: STUDY_CHAIR

Yonsei University

Locations

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Gong Je Seong

Seoul, , South Korea

Site Status RECRUITING

Countries

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South Korea

Central Contacts

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Gong Je Seong, MD, PhD

Role: CONTACT

Phone: 82-2-2019-3441

Email: [email protected]

Facility Contacts

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Gong Je Seong, MD, PhD

Role: primary

Other Identifiers

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3-2008-0076

Identifier Type: -

Identifier Source: org_study_id